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Results for the Protein: Q92887
308153583

MRP2_HUMAN RecName: Full=Canalicular multispecific organic anion transporter 1; AltName: Full=ATP-binding cassette sub-family C member 2; AltName: Full=Canalicular multidrug resistance protein; AltName: Full=Multidrug resistance-associated protein 2

Known Diseases associated with this Protein:
  DUBIN-JOHNSON SYNDROME (DJS)
4
20
0
0
24
Tips:
 The Domains on the Default View are decided by the Domain's E-Value.

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Default View:

MdlB - COG1132
PvdE - COG4615
ABC_membrane - pfam00664
COG1123 - COG1123
ABCC_SUR2 - cd03288
ABCC_CFTR1 - cd03291
TagH - COG1134
ABC_KpsT_Wzt - cd03220
SapF - COG4167
COG4586 - COG4586
PotA - COG3842
PstB - COG1117
ZnuC - COG1121
HisP - COG4598
MalK - COG3839
COG3638 - COG3638
CbiO - COG1122
Uup - COG0488
ABCG_PDR_domain1 - cd03233
TauB - COG1116
YhbG - COG1137
ABC_Carb_Monos_II - cd03215
ABCC_bacteriocin_exp - cd03245
FtsE - COG2884
ThiQ - COG3840
SalX - COG1136
AbcC - COG1135
OpuBA - COG1125
ABCC_CFTR2 - cd03289
Ttg2A - COG1127
CysA - COG1118
COG4619 - COG4619
ArtP - COG4161
COG4136 - COG4136
COG4181 - COG4181
TauB - COG4525
CcmA - COG4133
ABCC_SUR1_N - cd03290
ABCC_MRP_domain1 - cd03250
ABC_MTABC3_MDL1_MDL2 - cd03249
ABCC_Hemolysin - cd03252
ABCC_MsbA - cd03251
ABC_MJ0796_LolCDE_Ft - cd03255
ABCC_cytochrome_bd - cd03247
ABCC_Protease_Secret - cd03246
ABCF_EF-3 - cd03221
ABC_Class3 - cd03229
ABC_DR_subfamily_A - cd03230
ABCC_MRP_Like - cd03228
ABC_NrtD_SsuB_transp - cd03293
ABC_OpuCA_Osmoprotec - cd03295
ABC_MalK_N - cd03301
ABC_PotA_N - cd03300
ABC_ThiQ_thiamine_tr - cd03298
ABC_CysA_sulfate_imp - cd03296
ABC_cobalt_CbiO_doma - cd03226
ABC_Metallic_Cations - cd03235
ABC_ATPase - cd00267
ABC_cobalt_CbiO_doma - cd03225
ABCC_Glucan_exporter - cd03254
ABC_putative_ATPase - cd03269
CcmA - COG1131
GlnQ - COG1126
ABC_Iron-Siderophore - cd03214
ModC - COG4148
ABC_ModC_molybdenum_ - cd03297
ABCG_White - cd03234
ABC_CcmA_heme_export - cd03231
ABC_UvrA_II - cd03271
ABC_RNaseL_inhibitor - cd03237
CeuD - COG4604
ABC_FeS_Assembly - cd03217
ABC_RNaseL_inhibitor - cd03222
sufC - COG0396
AAA - smart00382
ABC_tran - pfam00005
SunT - COG2274
COG4178 - COG4178
CydD - COG4988
ArpD - COG4618
CydC - COG4987
ATM1 - COG5265
ABC_Pro_Gly_Betaine - cd03294
ModF - COG1119
ABCC_NFT1 - cd03369
AppF - COG4608
LivF - COG0410
DppF - COG1124
ABCC_TAP - cd03248
ABCG_EPDR - cd03213
FepC - COG1120
ABCC_MRP_domain2 - cd03244
DppD - COG0444
ABC_NikE_OppD_transp - cd03257
ABC_MetN_methionine_ - cd03258
ABC_Carb_Monos_I - cd03216
BtuD - COG4138
NatA - COG4555
ABC_DrrA - cd03265
ABC_YhbG - cd03218
ABCD_peroxisomal_ALD - cd03223
ABC_TM1139_LivF_bran - cd03224
ABC_NatA_like - cd03267
PhnK - COG1101
ABC_FtsE_transporter - cd03292
ABC_BcrA_bacitracin_ - cd03268
ABC_drug_resistance_ - cd03264
ABC_NatA_sodium_expo - cd03266
ABC_subfamily_A - cd03263
ABC_Carb_Solutes_lik - cd03259
ABC_PhnC_transporter - cd03256
ABC_Org_Solvent_Resi - cd03261
ABC_HisP_GlnQ - cd03262
ABCC_ATM1_transporte - cd03253
ABC_PstB_phosphate_t - cd03260
COG4559 - COG4559
ABC_Mj1267_LivG_bran - cd03219
LivG - COG0411
ABC_ModC_like - cd03299


Swiss-Prot Protein: Q92887
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Domains found on the Protein

Domain ↕CD Accession ↕E-Value ↕Start ↕End ↕
MdlBCOG11321.4e-71305865
COG1123COG11232.7e-06481864
ABCC_SUR2cd032881.4e-07560863
ABCC_CFTR1cd032917.8e-50600878
TagHCOG11345.8e-08605866
ABC_KpsT_Wztcd032203.9e-10608843
PstBCOG11171.6e-07632856
ZnuCCOG11213.3e-12633877
ABCG_PDR_domain1cd032330.00013634843
UupCOG04880.000116341098
TauBCOG11161.1e-09634873
YhbGCOG11371.7e-05634857
CbiOCOG11223.4e-11634864
ABC_Carb_Monos_IIcd032152.8e-07635839
ABCC_bacteriocin_expcd032451.4e-18635843
ABCC_CFTR2cd032893.3e-06636887
OpuBACOG11255.6e-06636955
AbcCCOG11354.1e-08636941
SalXCOG11362.8e-11636845
ABCF_EF-3cd032212.9e-08637838
ABC_Class3cd032291.3e-13637838
ABC_DR_subfamily_Acd032304.4e-12637839
ABCC_MRP_Likecd032281.3e-53637838
ABCC_Protease_Secretcd032461.6e-18637839
ABCC_cytochrome_bdcd032471.2e-16637843
ABC_MTABC3_MDL1_MDL2cd032492.2e-14637862
ABCC_MRP_domain1cd032501e-131637838
ABCC_Hemolysincd032523.3e-12637862
ABCC_MsbAcd032512.7e-20637859
ABC_MJ0796_LolCDE_Ftcd032552.6e-10637839
ABCC_SUR1_Ncd032902.4e-58637838
ABC_NrtD_SsuB_transpcd032931.6e-13637847
ABC_OpuCA_Osmoproteccd032957.8e-09637862
ABC_CysA_sulfate_impcd032963e-08637865
ABC_ThiQ_thiamine_trcd032988.4e-07637843
ABC_PotA_Ncd033003.8e-06637843
ABC_MalK_Ncd033013.9e-09637843
CysACOG11181.9e-09637966
Ttg2ACOG11273.4e-08637873
ABC_ATPasecd002673e-38638838
ABC_cobalt_CbiO_domacd032254.5e-17638838
ABC_cobalt_CbiO_domacd032264.2e-10638840
ABC_Metallic_Cationscd032355.4e-12638843
ABCC_Glucan_exportercd032545.3e-17638853
ABC_putative_ATPasecd032691.2e-05639843
CcmACOG11312.1e-10639915
ABC_Iron-Siderophorecd032147.8e-11640843
GlnQCOG11263e-08640863
ABCG_Whitecd032341.8e-06641843
ABC_ModC_molybdenum_cd032971.8e-08641843
ABC_CcmA_heme_exportcd032314.3e-05642838
ABC_UvrA_IIcd032710.00051644845
ABC_RNaseL_inhibitorcd032370.00093645867
ABC_FeS_Assemblycd032177.3e-07647854
ABC_RNaseL_inhibitorcd032221.8e-05648871
sufCCOG03961.5e-06652862
MdlBCOG11322.4e-1339611538
ABCC_SUR2cd032883.4e-9912241536
ABC_Pro_Gly_Betainecd032944.9e-0812711545
ModFCOG11193.1e-0812721518
ABCC_NFT1cd033691.9e-11912941518
CcmACOG11311.8e-1312961545
ABCG_EPDRcd032137.2e-0912971516
ABCC_TAPcd032481.6e-1512971512
LivFCOG04101.7e-1012971532
DppFCOG11241.3e-0812971541
CbiOCOG11221e-1712971535
ABCC_MRP_domain2cd032441.3e-15712981518
ABCC_bacteriocin_expcd032452.7e-3912981516
ABCC_Glucan_exportercd032541.8e-7412981526
ABCC_CFTR2cd032892.1e-3812981545
FepCCOG11201.1e-1012981545
ABC_NikE_OppD_transpcd032575.2e-1412991516
ABC_MetN_methionine_cd032586.2e-1112991526
DppDCOG04445.1e-0612991545
ABC_Carb_Monos_Icd032166.4e-1413001515
ABC_YhbGcd032184.5e-0613001526
ABCD_peroxisomal_ALDcd032238.5e-0913001512
ABC_TM1139_LivF_brancd032242.9e-1113001524
ABC_Class3cd032292.5e-1413001511
ABC_DR_subfamily_Acd032301.8e-1313001512
ABCC_MRP_Likecd032286.6e-7813001511
ABCC_Protease_Secretcd032465.5e-2013001512
ABCC_cytochrome_bdcd032472.3e-3413001516
ABC_MTABC3_MDL1_MDL2cd032491.6e-3513001535
ABCC_MRP_domain1cd032503.1e-1413001511
ABCC_Hemolysincd032521.1e-4713001536
ABCC_MsbAcd032516.2e-4613001532
ABCC_ATM1_transportecd032535.6e-3513001535
ABC_PhnC_transportercd032564.3e-1013001523
ABC_Carb_Solutes_likcd032591.6e-1113001516
ABC_PstB_phosphate_tcd032601.7e-1013001521
ABC_Org_Solvent_Resicd032619.8e-1313001530
ABC_HisP_GlnQcd032625.5e-1113001512
ABC_subfamily_Acd032632.4e-1013001522
ABC_drug_resistance_cd032649.1e-0813001516
ABC_DrrAcd032653.4e-0713001522
ABC_NatA_sodium_expocd032663.2e-0613001516
ABC_NatA_likecd032670.0008513001516
ABC_BcrA_bacitracin_cd032687.7e-0713001516
ABCC_SUR1_Ncd032902.2e-0613001511
ABC_FtsE_transportercd032925.8e-1013001512
PhnKCOG11011.7e-0713001544
ABC_ATPasecd002671.5e-4413011511
ABC_cobalt_CbiO_domacd032258.8e-1713011511
ABC_Iron-Siderophorecd032141.4e-1213011516
ABC_Mj1267_LivG_brancd032192.1e-1113131523
LivGCOG04116.9e-0913131520
ABC_ModC_likecd032991.5e-0913151540
PvdECOG46153.2e-07316853
ABC_membranepfam006648.7e-44322593
SapFCOG41679.3e-07624877
COG4586COG45860.00079625917
PotACOG38421.4e-07632976
COG3638COG36389.8e-10634876
MalKCOG38393e-07634942
HisPCOG45982.5e-06634866
FtsECOG28841.9e-07636847
ThiQCOG38404.8e-09636864
CcmACOG41332.6e-07637843
ArtPCOG41611.5e-07637865
COG4136COG41364.9e-05637842
COG4181COG41814.6e-06637843
TauBCOG45251.3e-11637882
COG4619COG46193.6e-07637850
ModCCOG41480.0004641990
CeuDCOG46045.2e-05645866
ABC_tranpfam000055.6e-22678789
SunTCOG22749.7e-328351534
COG4178COG41780.000799301524
ABC_membranepfam006648.1e-379781256
CydDCOG49888.6e-199801542
ArpDCOG46181.6e-0910011543
CydCCOG49871.1e-1010101535
ATM1COG52655.4e-1710461534
AppFCOG46082.3e-0812961544
BtuDCOG41380.0007913001544
NatACOG45552.4e-0913001539
COG4559COG45590.0001613071544
ABC_tranpfam000055.7e-2413411465
AAAsmart003821.4e-14663838
AAAsmart003824.2e-2313261511

Table of Mutations found on the Protein

Source ↕Mut_ID ↕Class ↕HGVS ↕Disease ↕
Swiss-ProtVAR_013330Polymorphismp.ALA1450THRN/A
Swiss-ProtVAR_013327Diseasep.ARG1150HISDubin-Johnson syndrome (DJS)
Swiss-ProtVAR_020227Polymorphismp.ARG353HISN/A
Swiss-ProtVAR_020231Polymorphismp.ARG1181LEUN/A
Swiss-ProtVAR_000099Diseasep.ARG768TRPDubin-Johnson syndrome (DJS)
Swiss-ProtVAR_029118Polymorphismp.ASN1063SERN/A
Swiss-ProtVAR_020226Polymorphismp.ASP333GLYN/A
Swiss-ProtVAR_020234Polymorphismp.CYS1515TYRN/A
Swiss-ProtVAR_010756Diseasep.GLN1382ARGDubin-Johnson syndrome (DJS)
Swiss-ProtVAR_013328Diseasep.ILE1173PHEDubin-Johnson syndrome (DJS)
Swiss-ProtVAR_020230Polymorphismp.ILE1036THRN/A
Swiss-ProtVAR_020228Polymorphismp.ILE670THRN/A
Swiss-ProtVAR_029117Polymorphismp.ILE982VALN/A
Swiss-ProtVAR_020229Polymorphismp.LEU849ARGN/A
Swiss-ProtVAR_029115Polymorphismp.LYS495GLUN/A
Swiss-ProtVAR_029113Polymorphismp.MET246LEUN/A
Swiss-ProtVAR_029116Polymorphismp.PHE562LEUN/A
Swiss-ProtVAR_020233Polymorphismp.PRO1291LEUN/A
Swiss-ProtVAR_013324Polymorphismp.SER281ASNN/A
Swiss-ProtVAR_013326Polymorphismp.SER789PHEN/A
Swiss-ProtVAR_024360Polymorphismp.THR1273ALAN/A
Swiss-ProtVAR_047152Polymorphismp.TYR39PHEN/A
Swiss-ProtVAR_020232Polymorphismp.VAL1188GLUN/A
Swiss-ProtVAR_013325Polymorphismp.VAL417ILEN/A



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