Results for the protein: Q9NYL2

Results for the Protein: Q9NYL2

313104215

51776

MLTK

NCBI, UniProt

MLTK_HUMAN RecName: Full=Mitogen-activated protein kinase kinase kinase MLT; AltName: Full=Human cervical cancer suppressor gene 4 protein; Short=HCCS-4; AltName: Full=Leucine zipper- and sterile alpha motif-containing kinase; AltName: Full=MLK-like mitogen-activated protein triple kinase; AltName: Full=Mixed lineage kinase-related kinase; Short=MLK-related kinase; Short=MRK; AltName: Full=Sterile alpha motif- and leucine zipper-containing kinase AZK

			0 14 0 6 8

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Swiss-Prot Protein: Q9NYL2

Identical to: NP_057737

Default View:

Domains found on the Protein

Domain ↕	CD Accession ↕	E-Value ↕	Start ↕	End ↕
PTKc_PDGFR_alpha	cd05105	1.9e-05	1	266
STKc_MAPKKK_Byr2_lik	cd06628	6.2e-20	1	262
STKc_TAO3	cd06633	4.3e-05	1	300
STKc_TAO1	cd06635	1.2e-06	1	300
STKc_myosinIIIB	cd06639	1.4e-07	1	260
STKc_PAK_I	cd06647	5.5e-08	1	281
STKc_myosinIIIA	cd06638	1.3e-09	1	259
STKc_PAK1	cd06654	2.3e-09	1	280
STKc_PAK2	cd06655	2.5e-08	1	281
STKc_PAK3	cd06656	2e-09	1	282
STKc_PAK6	cd06659	1.2e-07	1	285
STKc_JNK1	cd07875	0.00011	1	352
STKc_p38beta_MAPK11	cd07878	4.6e-05	1	305
PTK_Tyk2_rpt1	cd05076	2.3e-05	2	261
PTKc_Kit	cd05104	3.7e-06	2	264
STKc_MAPK4_6	cd07854	2.5e-06	2	306
STKc_CDK9	cd07865	5.4e-08	2	253
STKc_JNK2	cd07876	2.5e-06	2	328
STKc_TAO	cd06607	5.5e-08	3	319
PKc_MKK7	cd06618	3.3e-11	3	290
STKc_PCTAIRE1	cd07873	7.9e-05	3	299
STKc_p38gamma_MAPK12	cd07880	5.4e-06	3	332
PTKc_FGFR3	cd05100	7.2e-09	4	306
STKc_Sty1_Hog1	cd07856	6.6e-07	4	320
STKc_PFTAIRE2	cd07870	7.4e-06	4	295
PTKc_FGFR1	cd05098	1.7e-11	5	271
PTKc_FGFR2	cd05101	3.3e-10	5	271
STKc_TAO2	cd06634	2.8e-07	5	300
STKc_PAK5	cd06658	1.1e-06	5	267
PTKc_FGFR4	cd05099	1.1e-11	6	277
STKc_PAK	cd06614	2.6e-20	6	291
STKc_MAP4K4_6	cd06636	1.1e-06	6	260
STKc_STK10_LOK	cd06644	3.7e-08	6	283
STKc_MAP4K5	cd06646	2e-07	6	261
STKc_PAK4	cd06657	1.7e-06	6	284
STKc_JNK3	cd07874	1.1e-05	6	327
STKc_p38alpha_MAPK14	cd07877	0.00012	6	326
STKc_PAK_II	cd06648	6.2e-12	7	273
STKc_JNK	cd07850	2.2e-07	7	326
PTKc_EGFR_like	cd05057	7.8e-31	8	280
PTKc_Tie2	cd05088	9e-13	8	285
PTKc_EGFR	cd05108	3.5e-14	8	309
PTKc_HER4	cd05110	7.7e-11	8	285
PTKc_HER2	cd05109	1.5e-17	8	274
STKc_p38	cd07851	1.9e-08	8	299
STKc_CDK12	cd07864	8.1e-08	8	277
STKc_BUR1	cd07866	3.8e-07	8	253
PTKc_ALK_LTK	cd05036	1.5e-17	9	262
PTK_Ryk	cd05043	7.3e-13	9	267
PTKc_Abl	cd05052	1.8e-45	9	264
PTKc_FAK	cd05056	1e-32	9	268
PTKc_InsR	cd05061	4.4e-16	9	276
PTKc_IGF-1R	cd05062	1.5e-15	9	262
PTKc_Lck_Blk	cd05067	1.1e-25	9	263
PTKc_Frk_like	cd05068	1.5e-42	9	263
PTKc_Yes	cd05069	3.8e-24	9	263
PTKc_Fyn_Yrk	cd05070	5.3e-31	9	263
PTKc_Src	cd05071	1.2e-24	9	265
PTKc_Lyn	cd05072	1.8e-21	9	263
PTKc_Hck	cd05073	3.5e-21	9	263
PTKc_Csk	cd05082	3.3e-32	9	263
STKc_ASK	cd06624	7.2e-15	9	260
STKc_TNIK	cd06637	9.7e-08	9	259
STKc_MAPK15	cd07852	0.00018	9	291
STKc_TEY_MAPK_plant	cd07858	6.1e-08	9	326
PTK_CCK4	cd05046	3.4e-14	10	262
PTKc_Ror	cd05048	1.5e-14	10	263
PTKc_Trk	cd05049	9.4e-17	10	262
PTKc_DDR	cd05051	4.5e-12	10	262
PTKc_Musk	cd05050	1.1e-13	10	262
PTKc_EphR_A2	cd05063	5.4e-24	10	264
PTKc_EphR_A10	cd05064	1.7e-15	10	264
PTKc_Ror1	cd05090	1.4e-09	10	263
PTKc_Ror2	cd05091	3.6e-10	10	263
PTKc_TrkB	cd05093	7.2e-11	10	272
PTKc_TrkC	cd05094	1.4e-08	10	272
PTKc_DDR2	cd05095	1.4e-11	10	262
PTKc_DDR1	cd05096	3.7e-09	10	262
PTKc_DDR_like	cd05097	1.3e-09	10	262
PTKc_VEGFR3	cd05102	1.3e-06	10	267
PTKc_TrkA	cd05092	4.5e-15	10	262
PTKc_VEGFR2	cd05103	7.1e-07	10	267
PKc_MAPKK_Byr1_like	cd06620	3.2e-09	10	298
STKc_MAP4K3	cd06645	2.7e-07	10	261
PKc_MEK2	cd06649	5.6e-06	10	330
PKc_MEK1	cd06650	1e-05	10	337
PTKc_InsR_like	cd05032	6.9e-23	11	262
PTKc_EphR	cd05033	1.2e-20	11	264
PTKc_Src_like	cd05034	4.5e-24	11	263
PTKc_Jak_rpt2	cd05038	1.4e-23	11	264
PTKc_Csk_like	cd05039	8.3e-21	11	263
PTKc_FGFR	cd05053	1.6e-14	11	265
PTKc_Tec_like	cd05059	1e-21	11	261
PTKc_EphR_B	cd05065	2.3e-23	11	264
PTKc_EphR_A	cd05066	2.1e-22	11	264
PTKc_Chk	cd05083	1.1e-32	11	263
PTK_HER3	cd05111	8.6e-14	11	272
PTKc_Itk	cd05112	1.8e-33	11	261
PTKc_Btk_Bmx	cd05113	3.8e-37	11	261
PTKc_Tec_Rlk	cd05114	8.5e-34	11	261
PKc_MKK4	cd06616	2e-10	11	277
STKc_CDK5	cd07839	3.8e-07	12	296
STKc_CDK7	cd07841	2.5e-09	12	270
STKc_PCTAIRE_like	cd07844	3.2e-10	12	296
STKc_CDK10	cd07845	1.9e-08	12	335
STKc_PCTAIRE3	cd07871	1e-05	12	296
STKc_PCTAIRE2	cd07872	4e-05	12	279
STKc_PFTAIRE1	cd07869	6.8e-05	12	310
STKc_Nek	cd08215	2.5e-22	12	262
STKc_Nek8	cd08220	8.9e-09	12	260
PTKc_Jak1_rpt2	cd05079	8.1e-15	13	264
PTKc_Tyk2_rpt2	cd05080	6e-14	13	265
PTKc_Jak2_Jak3_rpt2	cd05081	5.8e-22	13	264
PTKc_Tie1	cd05089	9.7e-11	13	288
STKc_SLK_like	cd06611	2.3e-11	13	275
STKc_SLK	cd06643	1.5e-08	13	275
STKc_ERK1_2_like	cd07849	2.9e-07	13	323
STKc_Nek6_Nek7	cd08224	2.8e-11	13	265
STKc_Nek6	cd08228	1.6e-11	13	265
STKc_Nek7	cd08229	3.8e-12	13	265
STKc_ROCK_NDR_like	cd05573	2.4e-07	14	309
STKc_phototropin_lik	cd05574	3.1e-07	14	268
STKc_PKA	cd05580	3.7e-10	14	273
STKc_PDK1	cd05581	1.3e-14	14	265
STKc_DMPK_like	cd05597	3.7e-05	14	340
STKc_LATS	cd05598	0.00019	14	345
STKc_CRIK	cd05601	6.1e-06	14	304
STKc_MAST	cd05609	3.6e-05	14	305
STKc_PRKX_like	cd05612	2.8e-07	14	307
STKc_MRCK_beta	cd05624	0.00015	14	304
STKc_MRCK_alpha	cd05623	0.00045	14	310
STKc_myosinIII_like	cd06608	1.6e-12	14	259
STKc_OSR1_SPAK	cd06610	3.5e-14	14	253
STKc_MST1_2	cd06612	5.4e-17	14	256
STKc_MAP4K3_like	cd06613	1.5e-14	14	261
PKc_MEK	cd06615	7.5e-09	14	288
PKc_MKK3_6	cd06617	6.7e-11	14	278
PKc_MKK5	cd06619	1.1e-06	14	285
PKc_MAPKK_PBS2_like	cd06622	1.9e-08	14	311
PKc_MAPKK	cd06605	4.8e-12	14	258
PKc_MAPKK_plant_like	cd06623	4.5e-15	14	265
STKc_MST4	cd06640	4.8e-11	14	280
STKc_MST3	cd06641	3.3e-09	14	280
PKc_MAPKK_Pek1_like	cd06621	3.8e-10	14	266
STKc_STK25-YSK1	cd06642	2.9e-10	14	280
STKc_MEKK3_like_1	cd06653	5.1e-08	14	262
STKc_MEKK2	cd06652	2.5e-07	14	263
STKc_CdkB_plant	cd07837	6.6e-09	14	266
STKc_CDC2L1	cd07843	1.2e-07	14	253
STKc_CDKL2_3	cd07846	5e-06	14	253
STKc_CDKL1_4	cd07847	3.6e-08	14	296
STKc_ERK5	cd07855	3.3e-06	14	297
SPS1	COG0515	1.1e-37	14	459
PTKc_RET	cd05045	7.9e-10	15	267
PKc_STE	cd05122	6.5e-22	15	255
STKc_Yank1	cd05578	1.4e-09	15	263
STKc_MSK_N	cd05583	6.2e-06	15	285
STKc_cPKC	cd05587	9.5e-08	15	338
STKc_GRK4_like	cd05605	1e-05	15	272
STKc_MSK2_N	cd05614	0.00011	15	323
STKc_cPKC_beta	cd05616	1.1e-05	15	327
STKc_cPKC_alpha	cd05615	9.7e-06	15	349
STKc_GRK6	cd05630	8.1e-05	15	272
STKc_GRK4	cd05631	0.00014	15	272
STKc_GRK5	cd05632	9.9e-05	15	272
STKc_MAPKKK	cd06606	1.3e-23	15	253
STKc_Cdc7_like	cd06627	8.5e-21	15	257
STKc_MEKK3	cd06651	2.5e-09	15	256
STKc_CCRK	cd07832	6.7e-10	15	254
STKc_MAPK	cd07834	2.1e-10	15	298
STKc_Pho85	cd07836	6e-06	15	296
STKc_NLK	cd07853	6.6e-07	15	334
STKc_MPK1	cd07857	1.1e-07	15	306
STKc_TDY_MAPK_plant	cd07859	1.5e-06	15	326
STKc_CDK2_3	cd07860	1.3e-06	15	296
STKc_CDK1_euk	cd07861	3.4e-06	15	296
STKc_CDK4	cd07863	0.00054	15	268
STKc_Nek2	cd08217	1e-13	15	262
STKc_Nek1	cd08218	4.9e-17	15	260
STKc_Nek3	cd08219	1.7e-12	15	260
STKc_Nek4	cd08223	3e-09	15	259
STKc_Nek5	cd08225	8.7e-21	15	260
PK_STRAD	cd08216	2.4e-05	15	265
STKc_Nek10	cd08528	1e-08	15	262
STKc_FA2-like	cd08529	2.1e-13	15	259
STKc_CNK2-like	cd08530	6.2e-12	15	260
PTKc_Axl_like	cd05035	1.8e-10	16	264
PTKc_Tyro3	cd05074	2.3e-13	16	264
PTKc_Axl	cd05075	3.3e-07	16	264
STKc_CMGC	cd05118	7.2e-11	16	256
STKc_PKN	cd05589	6.2e-07	16	337
STKc_MAK_like	cd07830	1.9e-08	16	262
STKc_MOK	cd07831	1.3e-06	16	257
STKc_CDK1_like	cd07835	4.8e-07	16	296
STKc_CDK4_6_like	cd07838	1.9e-06	16	253
STKc_CDC2L6	cd07867	0.00094	16	308
PTKc_Srm_Brk	cd05148	1.3e-16	17	263
STKc_MST3_like	cd06609	5.1e-16	17	277
STKc_MEKK4	cd06626	1.2e-14	17	256
STKc_NAK1_like	cd06917	4.6e-13	17	268
STKc_CDKL	cd07833	1.5e-05	17	258
STKc_CDK6	cd07862	0.00071	17	296
STKc_CDK8_like	cd07842	1.3e-07	18	274
STKc_Nek11	cd08222	7e-16	18	262
STKc_RSK_N	cd05582	5.1e-05	19	335
STKc_p70S6K	cd05584	4.9e-05	19	339
STKc_CDK_like	cd07829	7.9e-14	19	259
STKc_CDK9_like	cd07840	3.8e-11	19	253
PTKc	cd00192	5.3e-52	20	261
PTK_Jak_rpt1	cd05037	1.5e-10	20	261
PTKc_Ack_like	cd05040	7.8e-38	20	262
PTKc_Fes_like	cd05041	1.2e-22	20	262
PTKc_Aatyk	cd05042	1.1e-09	20	262
PTKc_Tie	cd05047	1.5e-11	20	265
PTKc_Met_Ron	cd05058	1.8e-28	20	266
PTKc_Syk_like	cd05060	1.7e-20	20	265
PTK_Jak1_rpt1	cd05077	3.1e-07	20	261
PTK_Jak2_Jak3_rpt1	cd05078	7.3e-11	20	261
PTKc_Fes	cd05084	2.1e-25	20	262
PTKc_Fer	cd05085	5.8e-24	20	262
PTKc_Aatyk1_Aatyk3	cd05087	5.1e-06	20	262
PTKc_Aatyk2	cd05086	4.6e-07	20	262
PTKc_Syk	cd05116	2.9e-21	20	265
STKc_PKB	cd05571	2e-07	20	339
STKc_SGK	cd05575	5.6e-05	20	321
STKc_aPKC	cd05588	1.9e-05	20	338
STKc_nPKC_eta	cd05590	1.3e-05	20	338
STKc_nPKC_epsilon	cd05591	5e-07	20	338
STKc_nPKC_theta_delt	cd05592	1e-08	20	339
STKc_PKB_gamma	cd05593	0.00046	20	342
STKc_PKB_beta	cd05595	0.00025	20	339
STKc_SGK1	cd05602	0.00015	20	306
STKc_SGK2	cd05603	3.5e-06	20	336
STKc_PKB_alpha	cd05594	7.4e-06	20	326
STKc_nPKC_theta	cd05619	4.8e-07	20	339
STKc_nPKC_delta	cd05620	0.00039	20	339
STKc_MEKK1	cd06630	2.8e-09	20	254
STKc_MEKK1_plant	cd06632	1e-12	20	259
STKc_YSK4	cd06631	1.4e-10	20	260
PTKc_Zap-70	cd05115	8e-20	21	265
PKc	cd00180	1.2e-74	22	260
STKc_AGC	cd05123	3.4e-12	22	258
STKc_MAST_like	cd05579	9e-11	22	265
STKc_cGK_PKG	cd05572	2.3e-08	22	245
STKc_YPK1_like	cd05585	0.00018	22	317
STKc_Sck1_like	cd05586	0.00044	22	345
STKc_beta_ARK	cd05606	9.4e-05	22	280
STKc_GRK7	cd05607	4.5e-05	22	306
STKc_GRK1	cd05608	1.2e-05	22	271
STKc_GRK	cd05577	6.1e-07	22	271
PTKc_c-ros	cd05044	1.2e-12	23	262
STKc_PKC	cd05570	1.4e-08	23	304
STKc_MEKK3_like	cd06625	1.2e-14	23	262
STKc_MAPKKK_Bck1_lik	cd06629	6.4e-14	23	254
STKc_Nek9	cd08221	8.6e-11	23	262
	cd00166	9.7e-22	338	408
Pkinase	pfam00069	2.3e-62	16	260
SAM_1	pfam00536	4.8e-06	337	408
Pkinase_Tyr	pfam07714	3e-65	16	260
TyrKc	smart00219	9.2e-67	16	260
STYKc	smart00221	8.7e-53	16	262
S_TKc	smart00220	8e-60	26	263
KIND	smart00750	2.1e-06	88	265
SAM_2	pfam07647	2.2e-05	336	408
SAM	smart00454	1.1e-09	336	410

Table of Mutations found on the Protein

Source ↕	Mut_ID ↕	Class ↕	HGVS ↕	Disease ↕
dbSNP	rs7593622	Polymorphism	p.ARG580TRP	N/A
dbSNP	rs35853276	Polymorphism	p.LEU147MET	N/A
dbSNP	rs55830025	Polymorphism	p.LYS784THR	N/A
dbSNP	rs3769148	Polymorphism	p.SER531LEU	N/A
dbSNP	rs6758025	Polymorphism	p.THR267MET	N/A
dbSNP	rs35608243	Polymorphism	p.TYR773HIS	N/A
Swiss-Prot	VAR_040807	Polymorphism	p.ALA281THR	N/A
Swiss-Prot	VAR_040808	Polymorphism	p.ALA281VAL	N/A
Swiss-Prot	VAR_040809	Polymorphism	p.ARG580TRP	N/A
Swiss-Prot	VAR_040812	Polymorphism	p.LYS784THR	N/A
Swiss-Prot	VAR_040810	Polymorphism	p.PRO740THR	N/A
Swiss-Prot	VAR_022827	Polymorphism	p.SER531LEU	N/A
Swiss-Prot	VAR_040806	Polymorphism	p.THR267MET	N/A
Swiss-Prot	VAR_040811	Polymorphism	p.TYR773HIS	N/A

Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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