Results for the protein: P21709

Results for the Protein: P21709

317373566

2041

EPHA1

NCBI, UniProt

EPHA1_HUMAN RecName: Full=Ephrin type-A receptor 1; Short=hEpha1; AltName: Full=EPH tyrosine kinase; AltName: Full=EPH tyrosine kinase 1; AltName: Full=Erythropoietin-producing hepatoma receptor; AltName: Full=Tyrosine-protein kinase receptor EPH; Flags: Precursor

			0 9 0 3 6

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Swiss-Prot Protein: P21709

Identical to: NP_005223

Default View:

Domains found on the Protein

Domain ↕	CD Accession ↕	E-Value ↕	Start ↕	End ↕
FN3	cd00063	1.3e-07	448	535
PTKc_VEGFR	cd05054	6.1e-16	515	887
PTKc_Kit	cd05104	8.9e-15	588	884
PTKc_PDGFR_beta	cd05107	1.4e-09	590	885
PTKc_PDGFR_alpha	cd05105	2.4e-14	592	886
PTKc_CSF-1R	cd05106	1.3e-16	597	885
STKc_TAO1	cd06635	7.4e-05	598	924
STKc_myosinIIIB	cd06639	1.6e-05	599	883
STKc_PAK6	cd06659	1e-06	600	904
PTKc_FGFR1	cd05098	5e-38	601	891
PTKc_PDGFR	cd05055	1.9e-17	602	884
STKc_PAK5	cd06658	0.00016	603	899
PTKc_FGFR2	cd05101	1.1e-43	604	895
STKc_TAO3	cd06633	0.0006	604	924
STKc_PAK	cd06614	2.1e-14	605	897
STKc_PAK4	cd06657	9.8e-05	605	901
STKc_PAK_II	cd06648	1.3e-07	606	900
STKc_TAO	cd06607	1.3e-05	607	924
STKc_TAO2	cd06634	3.6e-06	607	925
PTK_Tyk2_rpt1	cd05076	2.1e-11	608	881
PTKc_FGFR3	cd05100	3.5e-34	608	929
STKc_myosinIIIA	cd06638	1.8e-05	608	882
STKc_MAP4K4_6	cd06636	5.7e-05	609	882
STKc_PAK3	cd06656	0.00012	609	907
STKc_p38	cd07851	0.00026	609	936
STKc_CDK9	cd07865	3.5e-06	609	896
PKc_MKK7	cd06618	3.4e-08	611	928
PTKc_FGFR4	cd05099	4e-50	612	899
STKc_ASK	cd06624	1.6e-07	613	884
PTKc_DDR	cd05051	5.2e-49	614	882
STKc_MAP4K3	cd06645	9e-05	614	881
STKc_MAP4K5	cd06646	0.00091	614	881
STKc_STK10_LOK	cd06644	2.4e-06	614	900
PTK_Ryk	cd05043	1e-30	615	883
PKc_MKK4	cd06616	1.4e-06	615	900
STKc_CDK12	cd07864	1.2e-09	615	907
PTKc_EGFR_like	cd05057	3.9e-79	616	894
PTKc_VEGFR3	cd05102	4.3e-19	616	887
PTKc_VEGFR2	cd05103	1.1e-16	616	886
PTKc_EGFR	cd05108	6.5e-58	616	933
PTKc_HER4	cd05110	1.7e-51	616	911
PTK_HER3	cd05111	1.3e-48	616	894
PTKc_HER2	cd05109	3.3e-56	616	894
PTKc_ALK_LTK	cd05036	3.4e-59	617	882
PTKc_FAK	cd05056	8.5e-90	617	888
PTKc_InsR_like	cd05032	5.2e-75	618	882
PTKc_Src_like	cd05034	2.9e-93	618	883
PTKc_Csk_like	cd05039	2.9e-79	618	883
PTK_CCK4	cd05046	3.8e-35	618	882
PTKc_Trk	cd05049	3.3e-66	618	882
PTKc_Ror	cd05048	5.2e-71	618	883
PTKc_Musk	cd05050	3.4e-64	618	882
PTKc_FGFR	cd05053	3.7e-44	618	885
PTKc_Abl	cd05052	3e-79	618	884
PTKc_InsR	cd05061	3.3e-52	618	895
PTKc_IGF-1R	cd05062	1.4e-54	618	882
PTKc_EphR_A10	cd05064	6.7e-114	618	884
PTKc_Lck_Blk	cd05067	2.4e-73	618	883
PTKc_Frk_like	cd05068	6e-94	618	883
PTKc_Yes	cd05069	1.8e-73	618	883
PTKc_EphR_A2	cd05063	1.1e-147	618	884
PTKc_Src	cd05071	7.1e-77	618	885
PTKc_Fyn_Yrk	cd05070	1.7e-74	618	883
PTKc_Hck	cd05073	1.6e-74	618	883
PTKc_Csk	cd05082	5.7e-67	618	883
PTKc_Ror1	cd05090	4.3e-65	618	883
PTKc_Ror2	cd05091	2.3e-56	618	883
PTKc_TrkA	cd05092	7.9e-53	618	882
PTKc_TrkB	cd05093	1.8e-50	618	891
PTKc_TrkC	cd05094	3.5e-26	618	891
PTKc_DDR2	cd05095	5.4e-51	618	882
PTKc_DDR1	cd05096	6.3e-44	618	882
PTKc_DDR_like	cd05097	8.3e-48	618	882
PTKc_Lyn	cd05072	7.1e-72	618	883
PTKc_Srm_Brk	cd05148	5e-73	618	883
PKc_MAPKK_Byr1_like	cd06620	8.8e-08	618	894
STKc_TNIK	cd06637	6e-06	618	882
STKc_ERK1_2_like	cd07849	4.5e-06	618	937
STKc_TEY_MAPK_plant	cd07858	6.6e-05	618	958
PTKc_EphR	cd05033	5.6e-210	619	884
PTKc_Jak_rpt2	cd05038	1.4e-65	619	884
PTKc_Tec_like	cd05059	1.5e-72	619	884
PTKc_EphR_B	cd05065	1.2e-140	619	884
PTKc_EphR_A	cd05066	9.3e-143	619	884
PTKc_Jak1_rpt2	cd05079	1.5e-42	619	884
PTKc_Tyk2_rpt2	cd05080	7.5e-21	619	885
PTKc_Chk	cd05083	2.4e-70	619	883
PTKc_Jak2_Jak3_rpt2	cd05081	3.6e-42	619	884
PTKc_Tie2	cd05088	6.4e-36	619	898
PTKc_Itk	cd05112	4e-72	619	881
PTKc_Btk_Bmx	cd05113	7.7e-71	619	881
PTKc_Tec_Rlk	cd05114	4.1e-72	619	881
STKc_myosinIII_like	cd06608	1.7e-08	619	880
STKc_SLK_like	cd06611	7.4e-08	619	886
STKc_SLK	cd06643	9e-08	619	898
STKc_PFTAIRE2	cd07870	2.7e-05	619	918
STKc_cPKC	cd05587	0.00029	620	934
STKc_MST3	cd06641	1.8e-07	620	900
STKc_STK25-YSK1	cd06642	3e-08	620	901
STKc_MST4	cd06640	2.3e-08	620	904
STKc_MEKK3_like	cd06625	4e-08	621	882
STKc_MEKK3	cd06651	2.9e-05	621	883
STKc_MEKK3_like_1	cd06653	0.00015	621	882
SPS1	COG0515	8.5e-19	621	974
STKc_MAST	cd05609	0.00021	622	945
STKc_PRKX_like	cd05612	6.2e-06	622	914
STKc_MAPKKK	cd06606	3e-17	622	882
PKc_MEK	cd06615	6.8e-06	622	902
PKc_MKK5	cd06619	0.00021	622	929
PKc_MAPKK_plant_like	cd06623	4.4e-11	622	889
STKc_MEKK4	cd06626	3.2e-07	622	880
STKc_Cdc7_like	cd06627	1.7e-14	622	880
STKc_YSK4	cd06631	2.6e-07	622	880
STKc_MAPKKK_Byr2_lik	cd06628	1.6e-12	622	882
STKc_Pho85	cd07836	7e-07	622	918
STKc_CDK7	cd07841	1.2e-09	622	877
STKc_CDKL5	cd07848	0.00093	622	907
STKc_MPK1	cd07857	0.0002	622	953
STKc_CDK1_euk	cd07861	5.8e-05	622	907
STKc_PCTAIRE2	cd07872	0.00022	622	899
STKc_PCTAIRE1	cd07873	0.00028	622	927
STKc_Nek4	cd08223	7.5e-07	622	880
STKc_Nek6_Nek7	cd08224	2.1e-07	622	885
STKc_Nek1	cd08218	4.6e-05	622	885
STKc_Nek6	cd08228	8.4e-06	622	885
STKc_Nek7	cd08229	2.1e-08	622	885
PTKc_RET	cd05045	4.6e-51	623	887
PTKc_Tie1	cd05089	1.5e-38	623	905
STKc_CDK1_like	cd07835	8.5e-07	623	907
STKc_MAPK	cd07834	1.1e-05	623	921
STKc_CDK9_like	cd07840	9.9e-09	623	873
STKc_PCTAIRE_like	cd07844	9.9e-07	623	907
STKc_NLK	cd07853	7.4e-06	623	951
STKc_TDY_MAPK_plant	cd07859	1.2e-05	623	958
STKc_PCTAIRE3	cd07871	0.00014	623	907
PTKc_Axl_like	cd05035	1.5e-67	624	884
PTKc_Tyro3	cd05074	3.5e-65	624	884
PTKc_Axl	cd05075	3.1e-54	624	884
STKc_PKA	cd05580	0.00016	624	896
STKc_PKN	cd05589	3.8e-06	624	931
PKc_MAPKK	cd06605	2.7e-08	624	885
PKc_MKK3_6	cd06617	3.3e-06	624	902
PKc_MAPKK_PBS2_like	cd06622	7.6e-07	624	929
STKc_CDK6	cd07862	4.6e-05	624	907
STKc_Nek3	cd08219	6.3e-09	624	882
STKc_Nek11	cd08222	2.9e-09	624	881
STKc_Nek5	cd08225	7.1e-05	624	880
PKc_STE	cd05122	5.6e-15	625	881
STKc_PDK1	cd05581	4e-07	625	884
STKc_CDK10	cd07845	3.6e-07	625	905
STKc_Sty1_Hog1	cd07856	0.00015	625	951
STKc_CDK2_3	cd07860	5.4e-06	625	907
STKc_CDK4	cd07863	3.1e-05	625	916
STKc_Nek	cd08215	1.5e-12	625	889
PK_STRAD	cd08216	0.00096	625	896
STKc_CNK2-like	cd08530	6.7e-06	625	880
STKc_Nek10	cd08528	0.00011	625	882
STKc_CRIK	cd05601	0.00041	626	936
STKc_Yank1	cd05578	8e-06	626	889
STKc_MST1_2	cd06612	1.9e-10	626	880
STKc_CDK_like	cd07829	1.6e-10	626	873
STKc_MAK_like	cd07830	4.3e-09	626	882
STKc_CDC2L1	cd07843	4.4e-08	626	873
STKc_CDK8_like	cd07842	6.1e-05	626	873
STKc_MAPK15	cd07852	3.6e-05	626	928
STKc_p70S6K	cd05584	9.7e-05	627	930
STKc_MST3_like	cd06609	1.3e-09	627	891
STKc_OSR1_SPAK	cd06610	3.6e-09	627	882
PKc_MAPKK_Pek1_like	cd06621	2.7e-08	627	901
PTKc	cd00192	3.1e-127	628	881
PTK_Jak_rpt1	cd05037	7.2e-13	628	881
PTKc_Ack_like	cd05040	9.8e-66	628	882
PTKc_Fes_like	cd05041	2.6e-85	628	882
PTKc_c-ros	cd05044	4.6e-67	628	882
PTKc_Tie	cd05047	1.3e-44	628	885
PTKc_Met_Ron	cd05058	1.5e-63	628	886
PTKc_Syk_like	cd05060	2.8e-79	628	885
PTK_Jak1_rpt1	cd05077	1.5e-12	628	881
PTK_Jak2_Jak3_rpt1	cd05078	6.6e-14	628	881
PTKc_Fes	cd05084	1.8e-78	628	882
PTKc_Fer	cd05085	1.1e-79	628	882
PTKc_Aatyk2	cd05086	3.2e-20	628	879
PTKc_Aatyk1_Aatyk3	cd05087	4.6e-23	628	882
PTKc_Zap-70	cd05115	4.4e-70	628	885
PTKc_Syk	cd05116	1.9e-62	628	885
STKc_PKC	cd05570	5.2e-06	628	931
STKc_PKB	cd05571	8.5e-05	628	938
STKc_SGK	cd05575	0.00039	628	931
STKc_RSK_N	cd05582	1.4e-05	628	931
STKc_nPKC_epsilon	cd05591	0.00017	628	932
STKc_nPKC_theta_delt	cd05592	8.9e-05	628	938
STKc_SGK1	cd05602	0.00099	628	953
STKc_SGK2	cd05603	0.00033	628	949
STKc_nPKC_theta	cd05619	2.7e-05	628	935
STKc_MAP4K3_like	cd06613	5.7e-08	628	881
STKc_MEKK1	cd06630	1.3e-05	628	882
STKc_CDK4_6_like	cd07838	4.2e-07	628	873
STKc_CDKL1_4	cd07847	8.1e-07	628	913
STKc_BUR1	cd07866	1.7e-07	628	899
STKc_FA2-like	cd08529	1.6e-08	628	880
STKc_phototropin_lik	cd05574	6.6e-05	629	892
STKc_MAPKKK_Bck1_lik	cd06629	1.2e-09	629	882
STKc_MEKK1_plant	cd06632	4e-08	629	880
STKc_NAK1_like	cd06917	1.6e-06	629	888
STKc_CCRK	cd07832	3e-07	629	874
STKc_CDKL	cd07833	0.0001	629	880
STKc_CdkB_plant	cd07837	3.5e-06	629	881
STKc_CDKL2_3	cd07846	8.4e-07	629	883
STKc_Nek2	cd08217	7.3e-06	629	882
STKc_Nek8	cd08220	4e-06	629	882
STKc_Nek9	cd08221	5.5e-07	629	885
PKc	cd00180	1e-63	630	880
PTKc_Aatyk	cd05042	6.1e-15	630	879
STKc_CMGC	cd05118	1.5e-12	630	880
STKc_AGC	cd05123	1.7e-07	630	879
STKc_cGK_PKG	cd05572	6.1e-07	630	880
STKc_MAST_like	cd05579	2.3e-06	630	879
STKc_YPK1_like	cd05585	3.4e-05	630	927
STKc_GRK7	cd05607	0.0004	630	910
STKc_GRK1	cd05608	0.00062	630	899
STKc_MOK	cd07831	9.5e-08	630	873
STKc_CDK5	cd07839	3.6e-06	630	896
STKc_MAPK4_6	cd07854	0.00012	630	935
	cd00166	1e-23	912	975
Ephrin_lbd	pfam01404	5.9e-105	27	204
fn3	pfam00041	2.6e-21	334	431
Pkinase	pfam00069	2.8e-34	624	880
SAM_1	pfam00536	8.8e-32	911	975
EPH_lbd	smart00615	1.1e-94	27	203
FN3	smart00060	9.3e-12	333	429
FN3	smart00060	5.7e-06	447	525
Pkinase_Tyr	pfam07714	1.8e-142	624	880
TyrKc	smart00219	1.4e-127	624	884
STYKc	smart00221	8.8e-52	624	882
S_TKc	smart00220	1.9e-38	634	884
KIND	smart00750	2e-05	708	890
SAM_2	pfam07647	8.3e-17	910	975
SAM	smart00454	1.3e-19	910	976

Table of Mutations found on the Protein

Source ↕	Mut_ID ↕	Class ↕	HGVS ↕	Disease ↕
Swiss-Prot	VAR_042117	Polymorphism	p.ALA585THR	N/A
Swiss-Prot	VAR_042115	Polymorphism	p.ARG351CYS	N/A
Swiss-Prot	VAR_028266	Polymorphism	p.ARG492GLN	N/A
Swiss-Prot	VAR_042116	Polymorphism	p.ARG575GLN	N/A
Swiss-Prot	VAR_042119	Polymorphism	p.GLU703LYS	N/A
dbSNP	rs6967117	Polymorphism	p.MET900VAL	N/A
dbSNP	rs34372369	Polymorphism	p.PRO697LEU	N/A
Swiss-Prot	VAR_042120	Polymorphism	p.SER807ARG	N/A
dbSNP	rs4725617	Polymorphism	p.VAL160ALA	N/A

Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

DMDM_info@umbc.edu | 1000 Hilltop Circle, Baltimore, MD 21250 | Department of Biological Sciences | Phone: 410-455-2258