Results for the protein: Q9Y616

Results for the Protein: Q9Y616

322510038

11213

IRAK3

NCBI, UniProt

IRAK3_HUMAN RecName: Full=Interleukin-1 receptor-associated kinase 3; Short=IRAK-3; AltName: Full=IL-1 receptor-associated kinase M; Short=IRAK-M

Known Diseases associated with this Protein:
ASTHMA SUSCEPTIBILITY 5

1

15

1

1

14

Tips:

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Swiss-Prot Protein: Q9Y616

Identical to: NP_009130

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Domains found on the Protein

Domain ↕	CD Accession ↕	E-Value ↕	Start ↕	End ↕
Death_IRAK	cd08309	5.1e-42	15	103
Death_IRAK4	cd08793	0.00013	15	110
Death_IRAK1	cd08794	0.00079	15	103
Death_IRAK2	cd08795	3.8e-06	15	103
Death_IRAK-M	cd08796	1.2e-74	15	103
Death_UNC5-like	cd08781	0.00048	20	103
Death_NFkB-like	cd08310	0.0001	24	103
PTKc_EGFR_like	cd05057	0.00064	137	463
PTKc_FAK	cd05056	0.00038	141	451
PTKc_DDR2	cd05095	3.1e-05	141	445
PTKc_DDR_like	cd05097	0.00018	141	445
STKc_PAK	cd06614	0.00017	142	419
PKc_MKK7	cd06618	2.4e-05	146	438
PTKc_Ror1	cd05090	3.9e-05	148	446
PTKc_ALK_LTK	cd05036	0.00064	151	445
PTKc_Frk_like	cd05068	2.9e-07	157	446
PTKc_Ror	cd05048	1.5e-05	157	386
STKc_CDK10	cd07845	0.00034	157	468
PTKc_Trk	cd05049	0.001	158	392
PTKc_Tec_Rlk	cd05114	0.00043	158	444
PTKc_Btk_Bmx	cd05113	2.9e-05	158	444
PTKc_Abl	cd05052	8e-06	159	447
PTKc_EphR_A	cd05066	1.2e-05	159	447
PTKc_Lck_Blk	cd05067	3.8e-05	159	446
PTKc_Yes	cd05069	7.3e-05	159	446
PTKc_Fyn_Yrk	cd05070	0.00044	159	446
PTKc_Src	cd05071	0.00022	159	448
PTKc_Hck	cd05073	1.4e-05	159	446
PTKc_Lyn	cd05072	0.00011	159	446
PTKc_Src_like	cd05034	7.3e-08	160	446
PTKc_Musk	cd05050	3e-05	160	445
STKc_STK25-YSK1	cd06642	0.00013	160	461
PTKc_EphR_A2	cd05063	1.1e-05	161	447
PTKc_EphR_A10	cd05064	3.5e-05	161	447
PTKc_EphR_B	cd05065	2.2e-06	161	447
PTKc_Csk	cd05082	6.8e-05	161	446
PTKc_Itk	cd05112	5.6e-06	161	444
PTKc_EphR	cd05033	2.6e-07	162	447
PTKc_Csk_like	cd05039	4.9e-06	162	393
PTKc_TrkA	cd05092	0.0006	162	434
STKc_Nek6_Nek7	cd08224	0.0005	162	448
STKc_Nek6	cd08228	0.00077	162	450
STKc_Nek7	cd08229	0.00038	162	448
PTKc_Jak2_Jak3_rpt2	cd05081	2e-05	163	447
STKc_phototropin_lik	cd05574	0.00074	163	418
STKc_MEKK3_like	cd06625	5.3e-05	163	445
STKc_CDKL1_4	cd07847	7.4e-05	163	451
SPS1	COG0515	1.1e-23	163	593
STKc_Yank1	cd05578	0.00047	164	422
STKc_MSK_N	cd05583	0.00057	164	466
STKc_MAPKKK	cd06606	1.1e-06	164	445
STKc_Cdc7_like	cd06627	2.4e-06	164	390
STKc_MAPKKK_Byr2_lik	cd06628	0.00023	164	445
STKc_CDK7	cd07841	0.00024	164	464
STKc_Nek	cd08215	8.7e-08	164	445
STKc_Nek3	cd08219	0.00063	164	445
PTKc_Jak_rpt2	cd05038	2.9e-07	165	447
PTKc_Tec_like	cd05059	9.8e-05	165	444
PTKc_Jak1_rpt2	cd05079	0.00076	165	447
PTKc_Tyk2_rpt2	cd05080	3.1e-06	165	448
STKc_CMGC	cd05118	9.8e-05	165	436
PKc_STE	cd05122	6.2e-07	166	435
PTKc_Srm_Brk	cd05148	2e-05	166	446
PK_STRAD	cd08216	0.00081	166	462
STKc_PDK1	cd05581	3.7e-07	167	403
PKc_MAPKK	cd06605	2.7e-05	167	445
STKc_FA2-like	cd08529	2.2e-05	168	450
PTKc	cd00192	1.7e-12	169	444
PTKc_Ack_like	cd05040	5.6e-05	169	445
PTKc_Fes_like	cd05041	1.6e-08	169	445
PTKc_c-ros	cd05044	0.0002	169	445
PTKc_Met_Ron	cd05058	1.5e-05	170	449
PTKc_Fer	cd05085	0.00046	170	445
STKc_PKB	cd05571	0.00071	170	512
PKc	cd00180	1.3e-40	171	443
PTKc_Fes	cd05084	4.3e-05	171	445
STKc_AGC	cd05123	3.5e-08	171	452
STKc_cGK_PKG	cd05572	0.00049	171	406
STKc_MAST_like	cd05579	0.00016	171	398
STKc_GRK7	cd05607	0.00085	171	461
STKc_OSR1_SPAK	cd06610	0.00011	171	403
PKc_MAPKK_Byr1_like	cd06620	0.00013	171	453
Death	pfam00531	1.8e-17	26	106
Pkinase	pfam00069	3.5e-12	165	443
DEATH	smart00005	4.1e-07	21	105
Pkinase_Tyr	pfam07714	2.7e-15	165	443
TyrKc	smart00219	1.4e-13	165	443
STYKc	smart00221	3.9e-15	165	436
S_TKc	smart00220	6.7e-11	172	446

Table of Mutations found on the Protein

Source ↕	Mut_ID ↕	Class ↕	HGVS ↕	Disease ↕
Swiss-Prot	VAR_040585	Polymorphism	p.ARG384GLN	N/A
Swiss-Prot	VAR_035216	Polymorphism	p.ARG429GLN	N/A
Swiss-Prot	VAR_040587	Polymorphism	p.ASP482ASN	N/A
Swiss-Prot	VAR_033901	Polymorphism	p.GLY269SER	N/A
Swiss-Prot	VAR_040582	Polymorphism	p.GLY84SER	N/A
Swiss-Prot	VAR_040581	Polymorphism	p.HIS57ARG	N/A
dbSNP	rs1152888	Polymorphism	p.ILE147VAL	N/A
Swiss-Prot	VAR_040583	Polymorphism	p.ILE171VAL	N/A
Swiss-Prot	VAR_031077	Polymorphism	p.ILE270VAL	N/A
Swiss-Prot	VAR_035215	Polymorphism	p.LEU400VAL	N/A
Swiss-Prot	VAR_040586	Polymorphism	p.MET391THR	N/A
Swiss-Prot	VAR_035213	Polymorphism	p.PRO111ALA	N/A
Swiss-Prot	VAR_035212	Polymorphism	p.PRO22LEU	N/A
Swiss-Prot	VAR_040584	Polymorphism	p.SER288LEU	N/A
Swiss-Prot	VAR_035214	Polymorphism	p.VAL134MET	N/A
OMIM	604459.0001	Disease	p.TRP76TER	ASTHMA SUSCEPTIBILITY 5

Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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