Results for the protein: Q76MJ5

Results for the Protein: Q76MJ5

327478597

10595

ERN2

NCBI, UniProt

ERN2_HUMAN RecName: Full=Serine/threonine-protein kinase/endoribonuclease IRE2; AltName: Full=Endoplasmic reticulum-to-nucleus signaling 2; AltName: Full=Inositol-requiring protein 2; Short=hIRE2p; AltName: Full=Ire1-beta; Short=IRE1b; Includes: RecName: Full=Serine/threonine-protein kinase; Includes: RecName: Full=Endoribonuclease; Flags: Precursor

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Swiss-Prot Protein: Q76MJ5

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Domains found on the Protein

Domain ↕	CD Accession ↕	E-Value ↕	Start ↕	End ↕
STKc_TAO1	cd06635	1.2e-05	497	814
STKc_JNK2	cd07876	0.001	498	821
STKc_TAO3	cd06633	0.00024	500	825
STKc_MAP4K4_6	cd06636	0.00015	502	781
STKc_JNK	cd07850	3.1e-05	503	805
STKc_TNIK	cd06637	0.0001	504	781
STKc_p38	cd07851	6.8e-09	504	836
STKc_PAK_I	cd06647	1.6e-05	505	804
STKc_PAK_II	cd06648	4.8e-07	505	795
STKc_PAK1	cd06654	2.7e-05	505	806
STKc_PAK2	cd06655	0.0001	505	807
STKc_PAK3	cd06656	4.9e-06	505	804
STKc_TAO	cd06607	5.3e-05	506	821
PKc_MAPKK_Byr1_like	cd06620	2.1e-05	506	798
STKc_TAO2	cd06634	1.6e-06	506	826
STKc_MST4	cd06640	7.5e-05	506	802
STKc_MST3	cd06641	1.9e-05	506	802
PTKc_Jak_rpt2	cd05038	7e-06	507	779
STKc_PAK	cd06614	1.8e-11	507	794
STKc_MAPKKK_Byr2_lik	cd06628	3.4e-10	508	781
STKc_PAK4	cd06657	0.00099	508	800
STKc_PAK5	cd06658	0.00065	508	798
STKc_PAK6	cd06659	6.9e-08	508	804
STKc_CDK9	cd07865	3.8e-08	508	781
STKc_Nek1	cd08218	6.6e-05	508	781
STKc_MAP4K5	cd06646	3.4e-06	510	780
PK_STRAD	cd08216	8.3e-05	510	800
PKc_MKK7	cd06618	6.4e-07	511	804
STKc_ASK	cd06624	5.1e-06	511	781
PTKc_EGFR_like	cd05057	0.0006	512	795
PTKc_EGFR	cd05108	0.00019	512	830
STKc_myosinIIIA	cd06638	1.7e-05	512	781
STKc_TEY_MAPK_plant	cd07858	9.6e-06	512	859
PTKc_ALK_LTK	cd05036	2.4e-06	513	781
PTKc_FAK	cd05056	0.00024	513	802
STKc_nPKC_theta_delt	cd05592	0.00046	513	843
STKc_CDK10	cd07845	6.6e-08	513	791
PTKc_Trk	cd05049	2.7e-05	514	800
STKc_MAPK15	cd07852	3.3e-06	514	827
STKc_ERK5	cd07855	2.9e-07	514	814
STKc_Sty1_Hog1	cd07856	2.4e-06	514	814
STKc_BUR1	cd07866	2e-09	514	781
STKc_PFTAIRE2	cd07870	2.9e-06	514	781
PTKc_Src_like	cd05034	3.7e-05	515	780
PTKc_Frk_like	cd05068	9e-05	515	780
PTKc_Tyk2_rpt2	cd05080	5.3e-05	515	803
STKc_PCTAIRE_like	cd07844	4.3e-06	515	819
STKc_ERK1_2_like	cd07849	1.4e-06	515	813
STKc_PFTAIRE1	cd07869	2.7e-05	515	793
STKc_PCTAIRE3	cd07871	0.00014	515	781
STKc_PCTAIRE2	cd07872	0.00036	515	839
STKc_PCTAIRE1	cd07873	0.00043	515	793
PTKc_Musk	cd05050	7e-05	516	778
STKc_MST1_2	cd06612	6.2e-10	516	781
STKc_MAP4K3_like	cd06613	1.2e-11	516	780
STKc_STK25-YSK1	cd06642	2.6e-05	516	802
STKc_CDK12	cd07864	3.5e-07	516	781
PTKc_Srm_Brk	cd05148	3.2e-05	517	791
STKc_STK10_LOK	cd06644	3.7e-05	517	802
STKc_MEKK3	cd06651	9.4e-07	517	783
STKc_MEKK2	cd06652	7.9e-05	517	782
STKc_MEKK3_like_1	cd06653	2.9e-05	517	781
STKc_ROCK_NDR_like	cd05573	8.2e-08	518	832
STKc_phototropin_lik	cd05574	1.7e-06	518	793
STKc_PKA	cd05580	2.8e-06	518	841
STKc_MAST	cd05609	0.00015	518	821
STKc_PRKX_like	cd05612	2.7e-05	518	824
PKc_MAPKK	cd06605	1.3e-08	518	787
STKc_MST3_like	cd06609	1.6e-06	518	798
PKc_MEK	cd06615	0.00011	518	798
PKc_MKK3_6	cd06617	8.8e-06	518	803
PKc_MKK5	cd06619	0.0009	518	806
PKc_MAPKK_plant_like	cd06623	3.6e-10	518	786
STKc_NAK1_like	cd06917	7.1e-08	518	789
STKc_MAPK4_6	cd07854	2.8e-06	518	813
STKc_Nek7	cd08229	1.1e-06	518	790
SPS1	COG0515	4e-30	518	916
PTKc_Ror	cd05048	0.00028	519	765
PKc_STE	cd05122	1.4e-13	519	780
STKc_MSK_N	cd05583	7.5e-06	519	796
STKc_Yank1	cd05578	4.5e-08	519	781
STKc_GRK4_like	cd05605	1.5e-06	519	806
STKc_MSK1_N	cd05613	0.00018	519	793
STKc_MSK2_N	cd05614	4.8e-05	519	846
STKc_GRK6	cd05630	0.00025	519	806
STKc_GRK4	cd05631	0.00024	519	806
STKc_GRK5	cd05632	6e-05	519	806
STKc_MAPKKK	cd06606	6.5e-18	519	781
STKc_myosinIII_like	cd06608	8.1e-07	519	781
STKc_Cdc7_like	cd06627	8e-13	519	781
STKc_YSK4	cd06631	1.8e-09	519	781
STKc_MAPK	cd07834	7.7e-10	519	812
STKc_Pho85	cd07836	1.7e-05	519	781
STKc_CdkB_plant	cd07837	1.5e-09	519	782
STKc_CDK5	cd07839	8.2e-09	519	781
STKc_CDK7	cd07841	4e-10	519	789
STKc_CDKL1_4	cd07847	4.5e-06	519	812
STKc_NLK	cd07853	3.3e-06	519	878
STKc_MPK1	cd07857	1.2e-06	519	846
STKc_TDY_MAPK_plant	cd07859	2.6e-07	519	859
STKc_CDK2_3	cd07860	8e-07	519	781
STKc_CDK1_euk	cd07861	1.9e-05	519	781
STKc_CDK6	cd07862	1.7e-05	519	781
STKc_CDK4	cd07863	1.6e-07	519	781
STKc_Nek	cd08215	4.2e-15	519	781
STKc_Nek2	cd08217	5.8e-08	519	781
STKc_Nek8	cd08220	6.5e-07	519	781
STKc_Nek9	cd08221	1.9e-06	519	781
STKc_Nek11	cd08222	0.00017	519	781
STKc_Nek4	cd08223	0.00011	519	781
STKc_Nek6_Nek7	cd08224	3.4e-07	519	790
STKc_Nek5	cd08225	4.1e-05	519	781
STKc_Nek6	cd08228	3.4e-05	519	790
STKc_Nek3	cd08219	3.8e-08	519	781
STKc_Nek10	cd08528	2.5e-06	519	781
STKc_FA2-like	cd08529	9.8e-06	519	781
STKc_CNK2-like	cd08530	4.6e-06	519	781
PTKc_Jak2_Jak3_rpt2	cd05081	4.3e-05	520	792
PTKc_Btk_Bmx	cd05113	0.001	520	780
STKc_CMGC	cd05118	1.1e-12	520	781
STKc_PDK1	cd05581	5.9e-12	520	781
STKc_CRIK	cd05601	6e-05	520	819
STKc_PKN	cd05589	0.00062	520	842
STKc_SLK_like	cd06611	1.3e-06	520	793
PKc_MKK4	cd06616	7.7e-06	520	795
STKc_SLK	cd06643	0.00012	520	797
STKc_CDK_like	cd07829	1.5e-14	520	781
STKc_MAK_like	cd07830	2.3e-11	520	781
STKc_CDK1_like	cd07835	3.7e-06	520	781
STKc_CDK4_6_like	cd07838	1.7e-12	520	781
STKc_CDK9_like	cd07840	1.1e-10	520	781
STKc_CDKL2_3	cd07846	8.4e-07	520	781
STKc_CDK8	cd07868	0.00082	520	781
STKc_MAP4K3	cd06645	2.1e-05	521	780
STKc_MEKK3_like	cd06625	1e-10	522	781
STKc_p70S6K	cd05584	0.00021	523	843
PTKc	cd00192	3.4e-08	524	780
PTKc_Ack_like	cd05040	8.5e-07	524	767
PTKc_Fes_like	cd05041	6e-06	524	767
PTKc_Syk_like	cd05060	0.00065	524	767
PTKc_Fes	cd05084	0.00048	524	781
PTKc_Fer	cd05085	0.00043	524	778
STKc_PKC	cd05570	8.9e-06	524	819
STKc_PKB	cd05571	0.00058	524	844
STKc_SGK	cd05575	0.00021	524	832
STKc_SGK1	cd05602	0.00027	524	838
STKc_SGK2	cd05603	7.6e-05	524	848
STKc_nPKC_theta	cd05619	0.00019	524	830
STKc_OSR1_SPAK	cd06610	6.5e-11	524	781
PKc_MAPKK_PBS2_like	cd06622	8.7e-06	524	805
STKc_MAPKKK_Bck1_lik	cd06629	7.2e-11	524	781
STKc_MEKK1	cd06630	1.5e-07	524	782
STKc_MOK	cd07831	4.1e-11	524	781
STKc_CDC2L1	cd07843	7.1e-08	524	781
STKc_CCRK	cd07832	3.1e-10	524	782
STKc_beta_ARK	cd05606	1.1e-05	525	801
STKc_GRK3	cd05633	0.00018	525	802
STKc_MEKK1_plant	cd06632	2.6e-13	525	781
STKc_CDKL	cd07833	7e-09	525	781
PKc	cd00180	2.7e-46	526	779
STKc_AGC	cd05123	2.9e-11	526	781
STKc_GRK	cd05577	1.3e-07	526	810
STKc_MAST_like	cd05579	2.3e-09	526	782
STKc_YPK1_like	cd05585	8.6e-05	526	841
STKc_cGK_PKG	cd05572	1.6e-07	526	784
STKc_GRK7	cd05607	6.5e-05	526	805
STKc_GRK1	cd05608	4.4e-06	526	805
PKc_MAPKK_Pek1_like	cd06621	3.3e-05	526	795
STKc_MEKK4	cd06626	3.3e-11	528	781
STKc_CDK8_like	cd07842	1.9e-07	533	781
Pkinase	pfam00069	8.5e-41	520	781
PQQ	smart00564	1e-05	34	65
Pkinase_Tyr	pfam07714	1.9e-10	518	781
TyrKc	smart00219	1.9e-10	520	781
STYKc	smart00221	2.2e-43	520	781
S_TKc	smart00220	8.9e-42	529	781
KIND	smart00750	0.00027	596	788
Ribonuc_2-5A	pfam06479	1.2e-73	786	912
PUG	smart00580	5.7e-24	844	899

Table of Mutations found on the Protein

Source ↕	Mut_ID ↕	Class ↕	HGVS ↕	Disease ↕
Swiss-Prot	VAR_040499	Polymorphism	p.ALA318THR	N/A
Swiss-Prot	VAR_040496	Polymorphism	p.ARG118CYS	N/A
Swiss-Prot	VAR_040497	Polymorphism	p.ARG184CYS	N/A
Swiss-Prot	VAR_040498	Polymorphism	p.ARG271GLN	N/A
Swiss-Prot	VAR_040503	Polymorphism	p.ARG537GLN	N/A
Swiss-Prot	VAR_040504	Polymorphism	p.HIS858TYR	N/A
Swiss-Prot	VAR_040500	Polymorphism	p.LEU410PHE	N/A
Swiss-Prot	VAR_040502	Polymorphism	p.LEU504PHE	N/A
Swiss-Prot	VAR_040501	Polymorphism	p.SER487THR	N/A
Swiss-Prot	VAR_040495	Polymorphism	p.VAL69ILE	N/A

Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

DMDM_info@umbc.edu | 1000 Hilltop Circle, Baltimore, MD 21250 | Department of Biological Sciences | Phone: 410-455-2258