Results for the protein: Q86UE8

Results for the Protein: Q86UE8

34222826

11011

TLK2

NCBI, UniProt

TLK2_HUMAN RecName: Full=Serine/threonine-protein kinase tousled-like 2; AltName: Full=HsHPK; AltName: Full=PKU-alpha; AltName: Full=Tousled-like kinase 2

			0 7 0 0 7

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Swiss-Prot Protein: Q86UE8

Default View:

Domains found on the Protein

Domain ↕	CD Accession ↕	E-Value ↕	Start ↕	End ↕
STKc_ROCK1	cd05622	0.00059	425	772
STKc_TAO1	cd06635	0.0002	425	751
PTKc_EGFR_like	cd05057	7.3e-06	433	744
STKc_ROCK	cd05596	3e-05	433	772
STKc_TAO3	cd06633	0.0006	439	751
STKc_JNK	cd07850	0.00034	440	770
STKc_myosinIIIB	cd06639	1.4e-05	441	742
STKc_p38alpha_MAPK14	cd07877	3.8e-05	441	772
STKc_MAP4K4_6	cd06636	0.00087	442	741
STKc_PAK5	cd06658	0.00024	443	749
STKc_PAK1	cd06654	1.1e-06	444	768
STKc_PAK6	cd06659	1.1e-05	444	752
STKc_p38	cd07851	2.9e-08	444	770
STKc_p38beta_MAPK11	cd07878	5.7e-05	444	772
STKc_TAO	cd06607	1.2e-05	445	761
STKc_myosinIIIA	cd06638	3.6e-07	445	741
STKc_PAK2	cd06655	7.7e-07	445	768
STKc_PAK3	cd06656	9.1e-07	445	771
STKc_TAO2	cd06634	9.2e-06	446	734
STKc_PAK	cd06614	3.6e-12	447	752
STKc_PAK_I	cd06647	1e-05	448	764
STKc_PAK4	cd06657	0.00038	448	751
STKc_CDK9	cd07865	3e-08	448	741
STKc_p38gamma_MAPK12	cd07880	5.7e-06	448	769
STKc_ASK	cd06624	3.9e-12	449	741
STKc_PAK_II	cd06648	1.7e-08	449	754
STKc_STK10_LOK	cd06644	2.9e-07	449	766
PTKc_TrkB	cd05093	3.8e-05	451	743
PKc_MKK7	cd06618	4.6e-09	451	761
STKc_MAP4K5	cd06646	0.00052	451	740
STKc_myosinIII_like	cd06608	3.1e-09	452	741
STKc_BUR1	cd07866	2.2e-08	452	740
STKc_Sty1_Hog1	cd07856	1.7e-06	452	771
PTKc_EphR_A2	cd05063	5.1e-05	453	741
PTKc_Musk	cd05050	9.9e-07	454	744
PTKc_DDR	cd05051	9.5e-06	454	734
PTKc_Ror1	cd05090	0.00047	454	724
PTKc_DDR1	cd05096	0.00018	454	744
STKc_MAP4K3	cd06645	0.00015	454	740
PTKc_Ror	cd05048	5e-06	455	724
PTKc_Abl	cd05052	5.7e-06	455	743
PTKc_FAK	cd05056	4.4e-08	455	750
PTKc_Lck_Blk	cd05067	0.00016	455	740
PTKc_Frk_like	cd05068	7e-07	455	742
PTKc_Fyn_Yrk	cd05070	0.0005	455	740
PTKc_Lyn	cd05072	9.2e-06	455	740
PTKc_TrkA	cd05092	6.1e-06	455	751
STKc_CDK12	cd07864	6.6e-12	455	764
STKc_MEKK2	cd06652	2.2e-06	456	742
STKc_MAPK15	cd07852	7.4e-09	456	749
STKc_CDK10	cd07845	3e-08	456	746
PTK_CCK4	cd05046	0.00037	457	738
PTKc_Yes	cd05069	0.0004	457	740
PTKc_HER2	cd05109	1.4e-05	457	746
PTKc_HER4	cd05110	0.00043	457	768
PTKc_Itk	cd05112	2.6e-08	457	736
PTK_HER3	cd05111	0.00043	457	746
STKc_PCTAIRE_like	cd07844	6.9e-16	457	760
STKc_TEY_MAPK_plant	cd07858	5.9e-07	457	772
STKc_ERK5	cd07855	1.5e-07	457	762
STKc_PFTAIRE2	cd07870	2.6e-08	457	741
PTKc_InsR_like	cd05032	0.00048	458	743
PTKc_EphR	cd05033	3.1e-06	458	741
PTKc_Jak_rpt2	cd05038	5.9e-10	458	743
PTKc_EphR_B	cd05065	2.3e-05	458	741
PTKc_Jak1_rpt2	cd05079	0.00016	458	743
PTKc_Tyk2_rpt2	cd05080	0.00012	458	738
PTKc_Jak2_Jak3_rpt2	cd05081	2.7e-06	458	743
PTKc_Btk_Bmx	cd05113	1.2e-06	458	740
PTKc_Tec_Rlk	cd05114	2.7e-05	458	740
STKc_MST1_2	cd06612	3.1e-12	458	741
STKc_MAP4K3_like	cd06613	2.3e-10	458	740
STKc_TNIK	cd06637	5e-05	458	741
STKc_SLK	cd06643	1.1e-08	458	764
STKc_ERK1_2_like	cd07849	6.1e-07	458	771
STKc_MAPK4_6	cd07854	1e-09	458	769
STKc_Nek6	cd08228	1.3e-07	458	741
PTKc_Trk	cd05049	8.8e-07	459	734
PTKc_EphR_A10	cd05064	0.00015	459	745
PTKc_EphR_A	cd05066	1.4e-05	459	741
PTKc_DDR2	cd05095	7.6e-06	459	741
PTKc_Hck	cd05073	0.0002	459	740
PTKc_DDR_like	cd05097	0.00016	459	743
PTKc_EGFR	cd05108	0.00061	459	771
STKc_SLK_like	cd06611	6.9e-08	459	751
PKc_MAPKK_plant_like	cd06623	2.2e-14	459	747
STKc_MST3	cd06641	9.6e-05	459	744
PKc_MEK2	cd06649	7.5e-05	459	772
STKc_MEKK3_like_1	cd06653	5.6e-08	459	745
PKc_MEK1	cd06650	0.00025	459	772
STKc_STK25-YSK1	cd06642	0.00054	459	762
STKc_PFTAIRE1	cd07869	6.2e-05	459	764
PTKc_Src_like	cd05034	6.1e-07	460	740
PTKc_ALK_LTK	cd05036	1.3e-07	460	738
STKc_ROCK_NDR_like	cd05573	6.8e-13	460	772
STKc_phototropin_lik	cd05574	1.3e-09	460	746
STKc_PDK1	cd05581	1.2e-17	460	741
STKc_DMPK_like	cd05597	0.0001	460	771
STKc_LATS	cd05598	1e-06	460	772
STKc_CRIK	cd05601	2.5e-07	460	772
STKc_MAST	cd05609	1.7e-07	460	772
STKc_PKA	cd05580	5.6e-11	460	766
STKc_PRKX_like	cd05612	1.5e-08	460	758
STKc_MRCK_alpha	cd05623	2e-05	460	769
STKc_NDR1	cd05628	7e-05	460	772
STKc_MRCK_beta	cd05624	9.8e-05	460	767
STKc_MST3_like	cd06609	4e-08	460	752
STKc_OSR1_SPAK	cd06610	6.7e-08	460	741
PKc_MAPKK	cd06605	6.8e-12	460	746
PKc_MEK	cd06615	8.5e-08	460	749
PKc_MKK3_6	cd06617	1.1e-07	460	760
PKc_MAPKK_Pek1_like	cd06621	2.3e-08	460	750
PKc_MAPKK_PBS2_like	cd06622	4.2e-08	460	762
PKc_MKK5	cd06619	9.6e-05	460	764
STKc_NAK1_like	cd06917	8.1e-08	460	760
STKc_CDKL	cd07833	4.7e-10	460	741
STKc_CdkB_plant	cd07837	2.2e-10	460	742
STKc_CDC2L1	cd07843	2.5e-07	460	741
STKc_CDKL2_3	cd07846	7.8e-08	460	741
STKc_CDKL1_4	cd07847	6.5e-16	460	741
STKc_CDK6	cd07862	3.1e-06	460	770
STKc_PCTAIRE3	cd07871	7.6e-09	460	766
STKc_PCTAIRE1	cd07873	2.3e-06	460	772
STKc_PCTAIRE2	cd07872	2.5e-08	460	763
STKc_Nek6_Nek7	cd08224	4.8e-09	460	741
STKc_Nek7	cd08229	1.7e-08	460	741
SPS1	COG0515	5.6e-38	460	772
PKc_STE	cd05122	4.3e-15	461	740
STKc_Yank1	cd05578	4e-16	461	741
STKc_MSK_N	cd05583	1.3e-08	461	754
STKc_cPKC	cd05587	2.3e-05	461	772
STKc_GRK4_like	cd05605	4.2e-07	461	768
STKc_MSK1_N	cd05613	2.3e-07	461	770
STKc_MSK2_N	cd05614	2.4e-06	461	770
STKc_cPKC_alpha	cd05615	1.2e-05	461	772
STKc_cPKC_beta	cd05616	0.00023	461	772
STKc_GRK6	cd05630	7.7e-05	461	768
STKc_GRK4	cd05631	6.4e-05	461	768
STKc_GRK5	cd05632	0.00011	461	766
STKc_MAPKKK	cd06606	3.1e-27	461	741
STKc_MEKK4	cd06626	3.6e-13	461	741
STKc_Cdc7_like	cd06627	5.6e-17	461	741
STKc_MAPKKK_Byr2_lik	cd06628	1.2e-20	461	741
STKc_MEKK3	cd06651	4e-08	461	743
STKc_CCRK	cd07832	3.1e-13	461	742
STKc_Pho85	cd07836	3.6e-09	461	741
STKc_CDK5	cd07839	2.7e-08	461	741
STKc_CDK7	cd07841	6.3e-14	461	743
STKc_CDK8_like	cd07842	4.5e-08	461	741
STKc_MAPK	cd07834	1.1e-11	461	759
STKc_NLK	cd07853	0.00031	461	769
STKc_MPK1	cd07857	7.6e-09	461	763
STKc_TDY_MAPK_plant	cd07859	8.7e-07	461	772
STKc_CDK2_3	cd07860	2e-06	461	741
STKc_CDK4	cd07863	1.1e-07	461	741
STKc_CDK1_euk	cd07861	5.3e-07	461	741
STKc_Nek	cd08215	1.3e-20	461	741
STKc_Nek2	cd08217	1.7e-11	461	741
STKc_Nek1	cd08218	2.9e-09	461	741
STKc_Nek3	cd08219	1.3e-09	461	741
STKc_Nek8	cd08220	5.8e-08	461	741
STKc_Nek11	cd08222	4e-15	461	741
STKc_Nek4	cd08223	1.9e-12	461	741
STKc_Nek5	cd08225	7.9e-13	461	741
STKc_Nek9	cd08221	1.5e-08	461	741
STKc_Nek10	cd08528	1.4e-09	461	738
STKc_FA2-like	cd08529	4.6e-13	461	741
STKc_CNK2-like	cd08530	2.6e-11	461	741
STKc_CMGC	cd05118	8.3e-15	462	741
PTKc_Srm_Brk	cd05148	4e-08	462	740
STKc_PKN	cd05589	4.8e-06	462	772
PKc_MKK4	cd06616	7.9e-07	462	759
STKc_CDK_like	cd07829	1.3e-18	462	741
STKc_MAK_like	cd07830	1.8e-10	462	741
STKc_MOK	cd07831	4.7e-11	462	741
STKc_CDK1_like	cd07835	9.7e-09	462	741
STKc_CDK4_6_like	cd07838	6.2e-13	462	741
STKc_CDK9_like	cd07840	5.7e-12	462	741
STKc_CDC2L6	cd07867	8.5e-06	464	741
STKc_CDK8	cd07868	8e-06	464	741
STKc_RSK_N	cd05582	4e-05	465	772
STKc_p70S6K	cd05584	1.4e-07	465	770
STKc_NDR_like	cd05599	3.4e-05	465	772
STKc_Rim15_like	cd05611	0.00014	465	738
PTKc	cd00192	1.5e-10	466	740
PTKc_Ack_like	cd05040	2.1e-09	466	737
PTKc_Fes_like	cd05041	2.9e-08	466	741
PTKc_c-ros	cd05044	2.7e-06	466	737
PTKc_Syk_like	cd05060	1e-08	466	740
PTK_Jak2_Jak3_rpt1	cd05078	0.00016	466	736
PTKc_Fes	cd05084	5.6e-06	466	737
PTKc_Fer	cd05085	7.4e-07	466	741
PTKc_Syk	cd05116	9.6e-09	466	742
STKc_PKC	cd05570	4.9e-09	466	759
STKc_PKB	cd05571	1.9e-09	466	772
STKc_SGK	cd05575	2.5e-07	466	771
STKc_aPKC	cd05588	1.8e-05	466	772
STKc_nPKC_eta	cd05590	0.00016	466	772
STKc_nPKC_epsilon	cd05591	1.5e-05	466	772
STKc_nPKC_theta_delt	cd05592	3.9e-06	466	769
STKc_PKB_alpha	cd05594	9.1e-09	466	771
STKc_PKB_beta	cd05595	2.3e-06	466	770
STKc_PKB_gamma	cd05593	7.8e-07	466	755
STKc_SGK1	cd05602	4.6e-06	466	770
STKc_SGK3	cd05604	3.2e-05	466	770
STKc_SGK2	cd05603	4.5e-08	466	772
STKc_aPKC_zeta	cd05617	0.00025	466	772
STKc_aPKC_iota	cd05618	0.00092	466	761
STKc_nPKC_theta	cd05619	5.3e-06	466	772
STKc_MEKK3_like	cd06625	8.6e-12	466	741
STKc_MEKK1	cd06630	1.4e-07	466	742
STKc_YSK4	cd06631	4.8e-07	466	741
STKc_MEKK1_plant	cd06632	1.3e-08	466	741
STKc_beta_ARK	cd05606	3.1e-06	467	761
STKc_GRK3	cd05633	9.9e-06	467	748
STKc_MAPKKK_Bck1_lik	cd06629	7.5e-09	467	741
PKc	cd00180	2.6e-80	468	739
PTKc_Zap-70	cd05115	2.5e-08	468	744
STKc_AGC	cd05123	4.9e-18	468	741
STKc_cGK_PKG	cd05572	5.3e-13	468	733
STKc_GRK	cd05577	4.6e-08	468	744
STKc_MAST_like	cd05579	7.6e-15	468	751
STKc_YPK1_like	cd05585	6.4e-05	468	772
STKc_Sck1_like	cd05586	8.1e-05	468	771
STKc_GRK7	cd05607	3.7e-07	468	766
STKc_GRK1	cd05608	4.4e-08	468	765
PKc_MAPKK_Byr1_like	cd06620	4.3e-07	481	755
PTKc_Tec_like	cd05059	2.3e-05	492	736
Pkinase	pfam00069	2.7e-64	462	741
Pkinase_Tyr	pfam07714	1.3e-15	462	739
TyrKc	smart00219	3.6e-13	462	739
STYKc	smart00221	2.5e-65	462	741
S_TKc	smart00220	2.5e-74	472	741

Table of Mutations found on the Protein

Source ↕	Mut_ID ↕	Class ↕	HGVS ↕	Disease ↕
Swiss-Prot	VAR_041219	Polymorphism	p.ALA108GLY	N/A
Swiss-Prot	VAR_041218	Polymorphism	p.ALA95GLY	N/A
Swiss-Prot	VAR_041222	Polymorphism	p.ARG262GLN	N/A
Swiss-Prot	VAR_041220	Polymorphism	p.ARG109LEU	N/A
Swiss-Prot	VAR_041217	Polymorphism	p.GLU54ASP	N/A
Swiss-Prot	VAR_041216	Polymorphism	p.HIS6ARG	N/A
Swiss-Prot	VAR_041221	Polymorphism	p.PHE173LEU	N/A

Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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