Results for the protein: NP

Results for the Protein: NP_001221

47078267

843

CASP10

NCBI

caspase-10 isoform 3 preproprotein [Homo sapiens]

Known Diseases associated with this Protein:
  AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME, TYPE IIA
  GASTRIC CANCER, SOMATIC
  NON-HODGKIN LYMPHOMA, SOMATIC

4

3

4

3

0

Tips:

The Domains on the Default View are decided by the Domain's E-Value.

Clicking a check box will display or hide the correlated domain.

To view the Gene page, either click on the link to the left or the blue bar above the Protein's graphic.

Default View: DED - smart00031 DED_Caspase_10_repea - cd08341 DED_FADD - cd08336 DED - pfam01335 DED_Caspase_8_10_rep - cd08792 DED_Caspase_8_repeat - cd08333 DED - cd00045 DED_Caspase-like_rep - cd08776 DED_Caspase_10_repea - cd08814 DED_Caspase_8_10_rep - cd08334 DED_Caspase_8_repeat - cd08813 CASc - cd00032 CASc - smart00115 Peptidase_C14 - pfam00656	RefSeq Protein: NP_001221 Default View:

Domains found on the Protein

Domain ↕	CD Accession ↕	E-Value ↕	Start ↕	End ↕
DED_Caspase_10_repea	cd08341	1.4e-58	18	99
DED	cd00045	1.4e-11	20	96
DED_Caspase_8_repeat	cd08333	1.4e-10	20	100
DED_Caspase-like_rep	cd08776	0.00046	20	95
DED_Caspase_8_10_rep	cd08792	1e-22	20	96
DED_Caspase_8_10_rep	cd08334	1.9e-35	112	190
DED_Caspase_8_repeat	cd08813	3.4e-06	112	190
DED_Caspase_10_repea	cd08814	4.1e-54	112	190
DED	cd00045	9.5e-07	115	182
CASc	cd00032	2.9e-122	232	471
DED	pfam01335	8.1e-27	20	102
DED	pfam01335	2.8e-27	115	193
Peptidase_C14	pfam00656	1.5e-73	241	470
DED	smart00031	4.9e-28	18	97
DED	smart00031	9.4e-25	113	188
CASc	smart00115	1.8e-127	233	472

Table of Mutations found on the Protein

Source ↕	Mut_ID ↕	Class ↕	HGVS ↕	Disease ↕
dbSNP	rs13006529	Polymorphism	p.LEU479ILE	N/A
dbSNP	rs17860405	Polymorphism	p.TYR403CYS	N/A
dbSNP	rs13010627	Polymorphism	p.VAL367ILE	N/A
OMIM	601762.0003	Disease	p.ALA371VAL	NON-HODGKIN LYMPHOMA, SOMATIC
OMIM	601762.0007	Disease	p.ILE363LEU	AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME, TYPE IIA
OMIM	601762.0001	Disease	p.LEU242PHE	AUTOIMMUNE LYMPHOPROLIFERATIVE SYNDROME, TYPE IIA
OMIM	601762.0006	Disease	p.MET147THR	GASTRIC CANCER, SOMATIC

Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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