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Results for the Protein:
NP_997647
47132557
2335
FN1
NCBI
fibronectin isoform 1 preproprotein [Homo sapiens]
Known Diseases associated with this Protein:
GLOMERULOPATHY WITH FIBRONECTIN DEPOSITS 2
3
3
3
3
0
Tips:
The Domains on the Default View are decided by the Domain's E-Value.
Clicking a check box will display or hide the correlated domain.
To view the Gene page, either click on the link to the left or the blue bar above the Protein's graphic.
Default View:
FN1 - cd00061
fn1 - pfam00039
FN1 - smart00058
ZnMc_MMP - cd04278
Peptidase_M10 - pfam00413
FN2 - smart00059
FN2 - cd00062
fn2 - pfam00040
FN3 - cd00063
fn3 - pfam00041
FN3 - smart00060
RefSeq Protein:
NP_997647
Default View:
Domains
found on the Protein
Domain ↕
CD Accession ↕
E-Value ↕
Start ↕
End ↕
FN1
cd00061
5e-20
95
138
FN1
cd00061
2.2e-19
139
182
FN1
cd00061
5.4e-22
184
228
FN1
cd00061
1.7e-19
229
273
ZnMc_MMP
cd04278
0.00023
245
479
FN1
cd00061
2.6e-12
306
345
FN2
cd00062
3.1e-30
354
401
FN2
cd00062
3.3e-30
414
461
FN1
cd00061
7.6e-20
468
511
FN1
cd00061
8e-19
516
558
FN1
cd00061
2e-19
559
602
FN3
cd00063
2.1e-11
608
699
FN3
cd00063
4.2e-09
720
809
FN3
cd00063
6.6e-21
811
898
FN3
cd00063
5.8e-18
907
995
FN3
cd00063
2.4e-19
997
1084
FN3
cd00063
9.7e-05
1087
1172
FN3
cd00063
1.5e-14
1174
1265
FN3
cd00063
4.3e-14
1267
1356
FN3
cd00063
6.4e-20
1358
1447
FN3
cd00063
1.1e-18
1449
1537
FN3
cd00063
2.8e-21
1539
1627
FN3
cd00063
2.5e-17
1633
1721
FN3
cd00063
6.3e-15
1723
1811
FN3
cd00063
1.9e-17
1813
1901
FN3
cd00063
9e-14
1905
1992
FN3
cd00063
1.6e-22
1994
2082
FN3
cd00063
1e-05
2191
2281
FN1
cd00061
4e-22
2295
2339
FN1
cd00061
1e-20
2340
2382
FN1
cd00061
1.1e-15
2384
2424
fn1
pfam00039
9.2e-17
52
87
fn1
pfam00039
1.8e-19
97
135
fn1
pfam00039
1.3e-18
141
179
fn1
pfam00039
2.3e-21
186
225
fn1
pfam00039
2.4e-20
231
270
Peptidase_M10
pfam00413
5.4e-05
245
491
fn1
pfam00039
2.3e-12
308
342
fn2
pfam00040
2.8e-26
360
401
fn2
pfam00040
2.6e-24
420
461
fn1
pfam00039
2.7e-20
470
508
fn1
pfam00039
1.8e-16
518
555
fn1
pfam00039
1e-18
561
599
fn3
pfam00041
3.9e-14
609
691
fn3
pfam00041
4.6e-15
720
800
fn3
pfam00041
4.8e-24
812
889
fn3
pfam00041
7.9e-23
908
986
fn3
pfam00041
2.7e-20
998
1075
fn3
pfam00041
3.8e-18
1175
1256
fn3
pfam00041
1.3e-18
1268
1350
fn3
pfam00041
7e-23
1359
1438
fn3
pfam00041
7.1e-22
1450
1528
fn3
pfam00041
4.6e-28
1540
1621
fn3
pfam00041
7.8e-22
1634
1712
fn3
pfam00041
7.9e-16
1724
1802
fn3
pfam00041
1.4e-20
1814
1892
fn3
pfam00041
3.1e-21
1906
1983
fn3
pfam00041
5.9e-25
1995
2073
fn3
pfam00041
0.00045
2193
2272
fn1
pfam00039
2.2e-20
2297
2336
fn1
pfam00039
7.4e-19
2342
2379
fn1
pfam00039
7.6e-16
2386
2421
FN1
smart00058
3.4e-18
52
92
FN1
smart00058
2.7e-20
97
140
FN1
smart00058
1.2e-20
141
184
FN1
smart00058
4e-22
186
230
FN1
smart00058
9.3e-21
231
275
FN1
smart00058
3.7e-14
308
347
FN2
smart00059
1.5e-31
353
401
FN2
smart00059
4.7e-31
413
461
FN1
smart00058
5.1e-20
470
513
FN1
smart00058
1.3e-19
518
560
FN1
smart00058
6.5e-19
561
604
FN3
smart00060
5e-07
609
690
FN3
smart00060
1.3e-08
720
799
FN3
smart00060
2.5e-16
811
889
FN3
smart00060
1e-14
907
986
FN3
smart00060
6.7e-14
997
1075
FN3
smart00060
1.3e-06
1087
1161
FN3
smart00060
3.6e-12
1174
1256
FN3
smart00060
6.6e-09
1267
1347
FN3
smart00060
1.7e-17
1358
1438
FN3
smart00060
1.9e-15
1449
1528
FN3
smart00060
1.9e-17
1539
1618
FN3
smart00060
1.4e-14
1633
1712
FN3
smart00060
1.5e-09
1723
1802
FN3
smart00060
1.5e-11
1813
1892
FN3
smart00060
2.2e-11
1905
1984
FN3
smart00060
1.8e-17
1994
2073
FN3
smart00060
0.001
2191
2272
FN1
smart00058
4.2e-21
2297
2341
FN1
smart00058
2.3e-22
2342
2384
FN1
smart00058
5.5e-17
2386
2426
Table of Mutations found on the Protein
Source ↕
Mut_ID ↕
Class ↕
HGVS ↕
Disease ↕
dbSNP
rs6728999
Polymorphism
p.ARG2275GLN
N/A
dbSNP
rs1250259
Polymorphism
p.GLN15LEU
N/A
dbSNP
rs17449032
Polymorphism
p.ILE2212VAL
N/A
OMIM
135600.0002
Disease
p.LEU1974ARG
GLOMERULOPATHY WITH FIBRONECTIN DEPOSITS 2
OMIM
135600.0001
Disease
p.TRP1925ARG
GLOMERULOPATHY WITH FIBRONECTIN DEPOSITS 2
OMIM
135600.0003
Disease
p.TYR983CYS
GLOMERULOPATHY WITH FIBRONECTIN DEPOSITS 2
Please Cite:
Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.
DMDM_info@umbc.edu
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