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Results for the Protein: NP_004963
4826776

tyrosine-protein kinase JAK2 [Homo sapiens]
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Tips:
 The Domains on the Default View are decided by the Domain's E-Value.

 Clicking a check box will display or hide the correlated domain.

 To view the Gene page, either click on the link to the left or the blue bar above the Protein's graphic.



Default View:

B41 - smart00295
SH2 - smart00252
SH2 - cd00173
SH2 - pfam00017
PTKc_EGFR_like - cd05057
PTKc_Jak1_rpt2 - cd05079
PTKc_HER2 - cd05109
PTKc_Hck - cd05073
PTKc_Lck_Blk - cd05067
PTKc_Chk - cd05083
PTKc_Lyn - cd05072
PTKc_Csk - cd05082
PTK_HER3 - cd05111
PTKc_InsR - cd05061
PTKc_Src - cd05071
PTKc_FAK - cd05056
PTKc_IGF-1R - cd05062
PTKc_Abl - cd05052
PTKc_Fyn_Yrk - cd05070
PTKc_Yes - cd05069
PTKc_Frk_like - cd05068
PTKc_TrkB - cd05093
PTKc_EphR_A10 - cd05064
PTKc_EphR_A2 - cd05063
PTKc_Ror1 - cd05090
PTKc_TrkA - cd05092
PTKc_Tec_Rlk - cd05114
PTKc_EphR_A - cd05066
PTKc_EphR_B - cd05065
PTKc_Itk - cd05112
PTKc_Btk_Bmx - cd05113
TyrKc - smart00219
STYKc - smart00221
Pkinase - pfam00069
Pkinase_Tyr - pfam07714
PTKc_Syk - cd05116
PTK_Jak2_Jak3_rpt1 - cd05078
PTKc - cd00192
PTK_Jak_rpt1 - cd05037
PTK_Jak1_rpt1 - cd05077
PTKc_Fes - cd05084
PTKc_Syk_like - cd05060
PTK_Tyk2_rpt1 - cd05076
PTKc_Met_Ron - cd05058
PTKc_Ack_like - cd05040
PTKc_Fer - cd05085
PTKc_Zap-70 - cd05115
PKc - cd00180
S_TKc - smart00220
PTKc_PDGFR_alpha - cd05105
PTKc_PDGFR_beta - cd05107
PTKc_VEGFR - cd05054
PTKc_Kit - cd05104
PTKc_CSF-1R - cd05106
STKc_myosinIIIB - cd06639
STKc_PAK1 - cd06654
STKc_PAK3 - cd06656
STKc_PAK_I - cd06647
STKc_MAP4K4_6 - cd06636
STKc_TAO1 - cd06635
PTKc_PDGFR - cd05055
STKc_TAO3 - cd06633
STKc_PAK5 - cd06658
STKc_PAK6 - cd06659
STKc_myosinIIIA - cd06638
STKc_PAK4 - cd06657
PKc_MKK7 - cd06618
STKc_TAO - cd06607
PTKc_FGFR1 - cd05098
STKc_STK10_LOK - cd06644
STKc_PAK_II - cd06648
STKc_PAK - cd06614
STKc_MAP4K5 - cd06646
PTKc_FGFR2 - cd05101
STKc_MAP4K3 - cd06645
STKc_p38 - cd07851
PTKc_FGFR - cd05053
STKc_TNIK - cd06637
STKc_CDK9 - cd07865
STKc_SLK_like - cd06611
PTKc_FGFR4 - cd05099
STKc_myosinIII_like - cd06608
STKc_BUR1 - cd07866
STKc_CDK10 - cd07845
PTKc_FGFR3 - cd05100
STKc_MST4 - cd06640
STKc_ASK - cd06624
STKc_MST3 - cd06641
STKc_TAO2 - cd06634
STKc_MEKK2 - cd06652
STKc_MEKK3_like - cd06625
PTKc_Tie2 - cd05088
STKc_TEY_MAPK_plant - cd07858
STKc_CRIK - cd05601
STKc_Sty1_Hog1 - cd07856
PTKc_ALK_LTK - cd05036
PTKc_VEGFR2 - cd05103
PTKc_VEGFR3 - cd05102
PTKc_DDR1 - cd05096
PTKc_DDR_like - cd05097
PTKc_Musk - cd05050
PKc_MEK2 - cd06649
STKc_ERK5 - cd07855
PTKc_TrkC - cd05094
STKc_MEKK3 - cd06651
PKc_MEK1 - cd06650
STKc_SLK - cd06643
PKc_MAPKK_Byr1_like - cd06620
PTKc_DDR2 - cd05095
PTKc_DDR - cd05051
PTKc_Ror - cd05048
PTKc_Trk - cd05049
PTK_CCK4 - cd05046
PTKc_Ror2 - cd05091
STKc_CDK12 - cd07864
STKc_ERK1_2_like - cd07849
PKc_MKK4 - cd06616
PTKc_Tec_like - cd05059
PTKc_InsR_like - cd05032
PTKc_Src_like - cd05034
PTKc_EphR - cd05033
PTKc_HER4 - cd05110
PTKc_EGFR - cd05108
PTKc_Tyk2_rpt2 - cd05080
PTKc_Jak2_Jak3_rpt2 - cd05081
PTKc_Jak_rpt2 - cd05038
STKc_PFTAIRE1 - cd07869
PTKc_Srm_Brk - cd05148
STKc_MAP4K3_like - cd06613
STKc_PCTAIRE_like - cd07844
STKc_PFTAIRE2 - cd07870
SPS1 - COG0515
STKc_MAPK15 - cd07852
STKc_STK25-YSK1 - cd06642
STKc_PCTAIRE1 - cd07873
PTKc_Csk_like - cd05039
PTK_Ryk - cd05043
STKc_MEKK3_like_1 - cd06653
STKc_MST1_2 - cd06612
STKc_CDKL1_4 - cd07847
STKc_PCTAIRE2 - cd07872
STKc_PCTAIRE3 - cd07871
STKc_CDK6 - cd07862
STKc_CDKL5 - cd07848
STKc_Nek11 - cd08222
STKc_Nek7 - cd08229
STKc_CDKL2_3 - cd07846
STKc_Nek6 - cd08228
STKc_Nek6_Nek7 - cd08224
PKc_MKK5 - cd06619
STKc_PRKX_like - cd05612
PKc_MAPKK - cd06605
STKc_OSR1_SPAK - cd06610
STKc_PKA - cd05580
STKc_CdkB_plant - cd07837
PTKc_Tie1 - cd05089
STKc_ROCK_NDR_like - cd05573
PKc_MKK3_6 - cd06617
STKc_phototropin_lik - cd05574
PKc_MEK - cd06615
STKc_NAK1_like - cd06917
STKc_MST3_like - cd06609
PKc_MAPKK_PBS2_like - cd06622
PKc_MAPKK_Pek1_like - cd06621
PKc_MAPKK_plant_like - cd06623
STKc_Nek8 - cd08220
STKc_CDK2_3 - cd07860
STKc_Nek3 - cd08219
STKc_Nek9 - cd08221
STKc_Nek - cd08215
STKc_Nek10 - cd08528
STKc_CNK2-like - cd08530
STKc_CDK1_euk - cd07861
STKc_FA2-like - cd08529
STKc_Nek1 - cd08218
STKc_Nek5 - cd08225
STKc_Nek4 - cd08223
STKc_Nek2 - cd08217
STKc_GRK4_like - cd05605
STKc_MSK1_N - cd05613
STKc_GRK6 - cd05630
STKc_GRK4 - cd05631
STKc_CDK4 - cd07863
STKc_MSK_N - cd05583
PTKc_RET - cd05045
PKc_STE - cd05122
STKc_Yank1 - cd05578
STKc_Cdc7_like - cd06627
STKc_MAPKKK - cd06606
STKc_CDK8_like - cd07842
STKc_NLK - cd07853
STKc_MPK1 - cd07857
STKc_TDY_MAPK_plant - cd07859
STKc_CDK5 - cd07839
STKc_CDK7 - cd07841
STKc_CCRK - cd07832
STKc_MAPK - cd07834
STKc_Pho85 - cd07836
STKc_CDK1_like - cd07835
STKc_PKN - cd05589
STKc_CDK_like - cd07829
STKc_MAK_like - cd07830
STKc_CMGC - cd05118
PTKc_Axl - cd05075
PTKc_Axl_like - cd05035
PTKc_Tyro3 - cd05074
STKc_CDK4_6_like - cd07838
STKc_MOK - cd07831
STKc_CDK9_like - cd07840
STKc_CDKL - cd07833
STKc_MAPKKK_Byr2_lik - cd06628
PK_STRAD - cd08216
STKc_PDK1 - cd05581
STKc_RSK_N - cd05582
STKc_MAPK4_6 - cd07854
STKc_MAPKKK_Bck1_lik - cd06629
STKc_MEKK1 - cd06630
STKc_MEKK1_plant - cd06632
STKc_MEKK4 - cd06626
STKc_nPKC_theta - cd05619
PTKc_Aatyk1_Aatyk3 - cd05087
PTKc_Tie - cd05047
STKc_PKB - cd05571
STKc_nPKC_theta_delt - cd05592
STKc_PKC - cd05570
PTKc_Fes_like - cd05041
PTKc_c-ros - cd05044
PTKc_Aatyk - cd05042
PTKc_Aatyk2 - cd05086
STKc_YSK4 - cd06631
STKc_AGC - cd05123
STKc_cGK_PKG - cd05572
STKc_GRK - cd05577
STKc_beta_ARK - cd05606
STKc_MAST_like - cd05579
STKc_GRK1 - cd05608
STKc_NDR_like - cd05599
STKc_CDC2L1 - cd07843


RefSeq Protein: NP_004963
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Domains found on the Protein

Domain ↕CD Accession ↕E-Value ↕Start ↕End ↕
SH2cd001731.2e-18398499
PTKc_EGFR_likecd050575.3e-11529818
PTKc_Jak1_rpt2cd050792e-07532809
PTKc_HER2cd051099.7e-09537818
PTKc_Ablcd050521.9e-18538809
PTKc_FAKcd050562.1e-17538813
PTKc_InsRcd050612.5e-09538818
PTKc_IGF-1Rcd050621.2e-09538807
PTKc_Frk_likecd050682.3e-25538808
PTKc_Yescd050698.2e-09538808
PTKc_Fyn_Yrkcd050701.6e-07538808
PTKc_Srccd050718.5e-08538810
PTKc_Lyncd050721.4e-07538808
PTKc_Hckcd050734.6e-08538808
PTKc_Lck_Blkcd050679.5e-07538808
PTKc_Cskcd050824.3e-08538808
PTKc_Chkcd050837.4e-08538808
PTK_HER3cd051112.3e-10538818
PTKc_EphR_A2cd050633.3e-08539809
PTKc_EphR_A10cd050642.1e-10539809
PTKc_Ror1cd050901e-08539808
PTKc_TrkAcd050921.7e-09539811
PTKc_TrkBcd050932.8e-09539817
PTKc_EphR_Bcd050651.5e-08540809
PTKc_EphR_Acd050665.1e-09540809
PTKc_Itkcd051123.6e-16540806
PTKc_Btk_Bmxcd051131.7e-16540806
PTKc_Tec_Rlkcd051144.1e-16540806
PTKccd001928.3e-65549806
PTK_Jak_rpt1cd050379.2e-184549806
PTKc_Ack_likecd050401.1e-15549807
PTKc_Met_Roncd050583e-07549811
PTKc_Syk_likecd050601.8e-15549814
PTK_Tyk2_rpt1cd050761.2e-95549806
PTK_Jak1_rpt1cd050771.3e-106549806
PTKc_Fescd050842.6e-11549807
PTKc_Fercd050852.6e-09549807
PTK_Jak2_Jak3_rpt1cd050784.1e-225549806
PTKc_Sykcd051163e-16549810
PTKc_Zap-70cd051151e-13550810
PKccd001809.6e-32551805
PTKc_PDGFR_alphacd051054.2e-117091129
PTKc_PDGFR_betacd051079.8e-077151128
PTKc_VEGFRcd050546.2e-127221130
PTKc_Kitcd051041.7e-107411127
PTKc_CSF-1Rcd051062.5e-078101128
STKc_myosinIIIBcd066391.4e-058131127
STKc_PAK1cd066540.00028171109
STKc_PAK_Icd066470.000138181131
STKc_PAK3cd066560.000348181111
STKc_MAP4K4_6cd066360.00018201126
STKc_TAO1cd066359.6e-078231132
PTKc_PDGFRcd050555e-148261126
STKc_TAO3cd066334e-058261125
STKc_PAK5cd066586.3e-058261106
STKc_myosinIIIAcd066381.4e-068271126
STKc_PAK6cd066594.6e-068271123
PKc_MKK7cd066185e-088281132
STKc_PAK4cd066577.1e-058281127
STKc_TAOcd066073.2e-078291132
PTKc_FGFR1cd050981.4e-338311131
STKc_STK10_LOKcd066442.5e-068321127
STKc_PAK_IIcd066488.1e-088321102
STKc_PAKcd066143e-138341065
PTKc_FGFR2cd051011.5e-348351131
STKc_MAP4K3cd066457e-068351099
STKc_MAP4K5cd066462.4e-068351099
STKc_p38cd078515.6e-078361131
PTKc_FGFRcd050531.1e-338381128
STKc_TNIKcd066372.2e-058381126
STKc_CDK9cd078654.7e-078381100
PTKc_FGFR4cd050991.8e-328391131
PTKc_FGFR3cd051004e-218391128
STKc_SLK_likecd066112.5e-098391132
STKc_myosinIII_likecd066086.1e-088391079
STKc_CDK10cd078455.1e-078391117
STKc_BUR1cd078665.9e-098391083
STKc_ASKcd066244.4e-118401126
STKc_TAO2cd066343.9e-088401128
STKc_MST4cd066405.4e-078401130
STKc_MST3cd066414.1e-078401130
PTKc_EGFR_likecd050579.9e-548411127
STKc_MEKK3_likecd066258.5e-198411126
STKc_MEKK2cd066527.8e-098411127
PTKc_ALK_LTKcd050365.4e-268421125
PTKc_FAKcd050563.5e-548421131
PTKc_Tie2cd050883.4e-228421132
STKc_CRIKcd056017.1e-058421131
STKc_Sty1_Hog1cd078566.5e-068421132
STKc_TEY_MAPK_plantcd078585.9e-058421132
PTKc_Rorcd050483.4e-328431126
PTKc_Trkcd050497.5e-448431125
PTK_CCK4cd050461.3e-388431125
PTKc_DDRcd050516.4e-318431125
PTKc_Ablcd050527.4e-558431127
PTKc_InsRcd050611.2e-258431132
PTKc_IGF-1Rcd050624.7e-278431125
PTKc_EphR_A2cd050631.2e-398431127
PTKc_EphR_A10cd050644.3e-308431127
PTKc_Frk_likecd050682.9e-638431126
PTKc_Yescd050691.3e-238431126
PTKc_Fyn_Yrkcd050704.6e-288431126
PTKc_Srccd050719.3e-218431128
PTKc_Lyncd050721.4e-428431126
PTKc_Hckcd050731.7e-408431126
PTKc_Lck_Blkcd050674.3e-478431126
PTKc_Cskcd050826.3e-468431126
PTKc_Ror1cd050901.3e-298431126
PTKc_Ror2cd050918.6e-318431126
PTKc_TrkAcd050922.1e-438431125
PTKc_DDR2cd050958.7e-398431125
PTKc_TrkCcd050941.4e-258431124
PTKc_DDR1cd050964.6e-278431125
PTKc_DDR_likecd050971.6e-368431125
PTKc_VEGFR3cd051021.9e-118431129
PTKc_VEGFR2cd051035.4e-138431130
PTKc_Muskcd050509.2e-368431125
PKc_MAPKK_Byr1_likecd066202e-088431131
STKc_SLKcd066432.1e-068431131
PKc_MEK1cd066500.000368431132
STKc_MEKK3cd066511.7e-128431126
PKc_MEK2cd066494.1e-058431130
STKc_ERK5cd078552.9e-058431130
PTKc_InsR_likecd050327.3e-328441125
PTKc_EphRcd050331e-368441127
PTKc_Src_likecd050341.3e-448441126
PTKc_Jak_rpt2cd050384.5e-2158441127
PTKc_Tec_likecd050591.9e-328441124
PTKc_EphR_Bcd050656.6e-378441127
PTKc_EphR_Acd050662e-468441127
PTKc_Jak1_rpt2cd050793.5e-1348441127
PTKc_Tyk2_rpt2cd050803.7e-1358441128
PTKc_Jak2_Jak3_rpt2cd050813.1e-2428441127
PTKc_Chkcd050835.3e-478441126
PTKc_TrkBcd050938.8e-328441128
PTKc_HER2cd051091.2e-388441131
PTKc_EGFRcd051083.5e-268441132
PTKc_HER4cd051106.1e-268441131
PTK_HER3cd051117.1e-398441132
PTKc_Itkcd051121.1e-358441124
PTKc_Btk_Bmxcd051132.5e-488441124
PTKc_Tec_Rlkcd051142e-428441124
PKc_MKK4cd066164.2e-088441127
STKc_ERK1_2_likecd078491.4e-068441131
STKc_CDK12cd078641.6e-108441126
PTKc_Srm_Brkcd051488.5e-378451126
STKc_MAP4K3_likecd066132.5e-118451096
STKc_PCTAIRE_likecd078442.6e-078451126
STKc_PFTAIRE1cd078690.000698451128
STKc_PFTAIRE2cd078702.7e-058451131
PTK_Rykcd050433.5e-178461119
PTKc_Csk_likecd050394.5e-248461126
STKc_MST1_2cd066121.4e-148461126
STKc_STK25-YSK1cd066425.6e-088461130
STKc_MEKK3_like_1cd066531e-108461126
STKc_CDKL1_4cd078473.3e-098461126
STKc_MAPK15cd078522.5e-088461126
STKc_PCTAIRE3cd078711.3e-068461126
STKc_PCTAIRE2cd078728.1e-068461131
STKc_PCTAIRE1cd078733.1e-068461128
SPS1COG05152.7e-128461132
PTKc_Tie1cd050892.3e-268471131
STKc_ROCK_NDR_likecd055730.000138471122
STKc_phototropin_likcd055743.9e-068471096
STKc_PKAcd055801.2e-088471099
STKc_PRKX_likecd056123.5e-078471114
PKc_MAPKKcd066057.4e-128471125
STKc_OSR1_SPAKcd066104.9e-108471087
PKc_MKK3_6cd066178.6e-088471128
PKc_MEKcd066151.3e-098471132
PKc_MKK5cd066196.7e-058471123
PKc_MAPKK_Pek1_likecd066214.6e-128471106
PKc_MAPKK_plant_likecd066231.3e-158471129
STKc_MST3_likecd066091.4e-128471086
PKc_MAPKK_PBS2_likecd066222.6e-068471132
STKc_NAK1_likecd069174.8e-098471083
STKc_CdkB_plantcd078372.7e-088471127
STKc_CDKL2_3cd078461.6e-088471126
STKc_CDKL5cd078487.3e-058471126
STKc_CDK6cd078620.000238471131
STKc_Nek11cd082228.3e-078471126
STKc_Nek6_Nek7cd082242.3e-088471132
STKc_Nek6cd082286.8e-078471132
STKc_Nek7cd082297.4e-098471132
PTKc_RETcd050456.1e-298481130
PKc_STEcd051226.5e-168481125
STKc_Yank1cd055789.6e-108481100
STKc_MSK_Ncd055836.8e-068481118
STKc_GRK4_likecd056053.3e-058481129
STKc_MSK1_Ncd056138.9e-058481132
STKc_GRK6cd056300.000828481129
STKc_GRK4cd056310.000138481129
STKc_MAPKKKcd066064.6e-298481119
STKc_Cdc7_likecd066272.5e-188481119
STKc_CCRKcd078328.3e-088481085
STKc_MAPKcd078347.1e-108481126
STKc_Pho85cd078369.5e-078481126
STKc_CDK5cd078396.8e-078481126
STKc_CDK7cd078414.8e-108481083
STKc_CDK8_likecd078424.4e-068481126
STKc_NLKcd078530.000178481131
STKc_MPK1cd078571e-058481123
STKc_TDY_MAPK_plantcd078598.2e-058481132
STKc_CDK4cd078631.2e-068481129
STKc_CDK1_eukcd078619.8e-078481131
STKc_CDK2_3cd078601.4e-068481126
STKc_Nekcd082151.1e-168481126
STKc_Nek3cd082197.6e-108481125
STKc_Nek2cd082171.8e-118481126
STKc_Nek8cd082203.4e-088481107
STKc_Nek9cd082211.1e-078481123
STKc_Nek4cd082237e-118481126
STKc_Nek5cd082250.000118481125
STKc_Nek1cd082188e-078481126
STKc_Nek10cd085289.1e-088481125
STKc_FA2-likecd085296.4e-108481126
STKc_CNK2-likecd085307.9e-098481121
PTKc_Axl_likecd050353.4e-378491127
PTKc_Tyro3cd050741.9e-338491127
PTKc_Axlcd050752.9e-248491127
STKc_CMGCcd051188.9e-148491126
STKc_PKNcd055890.000188491122
STKc_CDK_likecd078291.9e-148491119
STKc_MAK_likecd078301.7e-128491116
STKc_MOKcd078312.9e-098491116
STKc_CDK4_6_likecd078388.4e-108491081
STKc_CDK9_likecd078401.4e-118491126
STKc_CDK1_likecd078351.6e-088491129
STKc_PDK1cd055812.2e-118501085
STKc_MAPKKK_Byr2_likcd066281.4e-218501126
STKc_CDKLcd078338.4e-108501116
PK_STRADcd082160.000248501128
STKc_RSK_Ncd055820.000318521132
STKc_MAPK4_6cd078541e-058521113
PTKccd001925.4e-1028531124
PTKc_Ack_likecd050405.4e-578531125
PTKc_Fes_likecd050415.3e-388531125
PTKc_Aatykcd050423.3e-118531121
PTKc_c-roscd050445.6e-278531125
PTKc_Tiecd050471.2e-348531128
PTKc_Met_Roncd050581.7e-508531129
PTKc_Syk_likecd050603.9e-578531128
PTKc_Fescd050841.9e-408531125
PTKc_Fercd050851.5e-388531125
PTKc_Aatyk2cd050866.6e-098531125
PTKc_Aatyk1_Aatyk3cd050872.3e-138531125
PTKc_Sykcd051165.6e-528531128
STKc_PKCcd055702.2e-058531130
STKc_PKBcd055710.000658531124
STKc_nPKC_theta_deltcd055920.000598531132
STKc_nPKC_thetacd056192.8e-058531132
STKc_MEKK4cd066269.8e-118531120
STKc_MAPKKK_Bck1_likcd066292.2e-118531077
STKc_MEKK1cd066301.7e-088531122
STKc_MEKK1_plantcd066328.4e-148531123
PTKc_Zap-70cd051154.9e-518541128
PKccd001801.5e-628551123
STKc_AGCcd051233.2e-098551130
STKc_cGK_PKGcd055723.5e-098551114
STKc_GRKcd055776.8e-078551124
STKc_MAST_likecd055792.4e-098551116
STKc_beta_ARKcd056060.0018551121
STKc_GRK1cd056087.1e-088551128
STKc_YSK4cd066319.7e-128551126
STKc_NDR_likecd055990.000388561124
STKc_CDC2L1cd078432.2e-088611099
SH2pfam000170.00013401481
Pkinasepfam000696e-11545805
Pkinasepfam000694.7e-378491123
B41smart002951.2e-5634270
SH2smart002526e-18397487
Pkinase_Tyrpfam077143.6e-84545805
TyrKcsmart002199.4e-25545805
STYKcsmart002214e-14545811
S_TKcsmart002201.5e-11555809
Pkinase_Tyrpfam077142.4e-1398491123
TyrKcsmart002198e-1388491123
STYKcsmart002212.3e-548491096
S_TKcsmart002201.5e-488591127


Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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