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Results for the Protein: Q9NWZ3
50401181

IRAK4_HUMAN RecName: Full=Interleukin-1 receptor-associated kinase 4; Short=IRAK-4; AltName: Full=Renal carcinoma antigen NY-REN-64

Known Diseases associated with this Protein:
  IRAK4 DEFICIENCY
2
6
2
1
5
Tips:
 The Domains on the Default View are decided by the Domain's E-Value.

 Clicking a check box will display or hide the correlated domain.

 To view the Gene page, either click on the link to the left or the blue bar above the Protein's graphic.



Default View:

Death_Tube - cd08308
Death_IRAK4 - cd08793
Death_IRAK-M - cd08796
Death_IRAK - cd08309
Death - cd01670
PTKc_Kit - cd05104
PTKc_VEGFR2 - cd05103
PTKc_VEGFR3 - cd05102
STKc_JNK - cd07850
STKc_PAK5 - cd06658
STKc_PAK6 - cd06659
STKc_PAK1 - cd06654
STKc_TAO1 - cd06635
STKc_TAO3 - cd06633
PTKc_EGFR_like - cd05057
STKc_PAK4 - cd06657
STKc_PAK3 - cd06656
STKc_PAK_I - cd06647
STKc_PAK - cd06614
STKc_PAK2 - cd06655
STKc_MAP4K4_6 - cd06636
STKc_PAK_II - cd06648
PTKc_FGFR1 - cd05098
PTK_CCK4 - cd05046
STKc_p38 - cd07851
STKc_myosinIIIB - cd06639
STKc_Sty1_Hog1 - cd07856
STKc_BUR1 - cd07866
STKc_myosinIIIA - cd06638
STKc_ASK - cd06624
STKc_STK10_LOK - cd06644
PTKc_PDGFR - cd05055
PTKc_FGFR2 - cd05101
STKc_TAO - cd06607
PKc_MEK2 - cd06649
STKc_TAO2 - cd06634
STKc_CDK10 - cd07845
STKc_MAP4K5 - cd06646
STKc_MAP4K3 - cd06645
PTKc_EphR_A10 - cd05064
PTKc_Ror2 - cd05091
PKc_MKK7 - cd06618
PTKc_FGFR3 - cd05100
STKc_myosinIII_like - cd06608
PTKc_FGFR4 - cd05099
STKc_MAPK15 - cd07852
PTKc_HER2 - cd05109
PTK_HER3 - cd05111
PTKc_HER4 - cd05110
PTKc_EGFR - cd05108
STKc_CDK9 - cd07865
STKc_Nek6_Nek7 - cd08224
PKc_MAPKK_Byr1_like - cd06620
PKc_MAPKK_plant_like - cd06623
STKc_CDKL5 - cd07848
STKc_PRKX_like - cd05612
STKc_SLK - cd06643
STKc_PKA - cd05580
STKc_PDK1 - cd05581
PTKc_ALK_LTK - cd05036
STKc_ROCK_NDR_like - cd05573
STKc_CRIK - cd05601
PTKc_Itk - cd05112
PTKc_TrkC - cd05094
PTKc_DDR_like - cd05097
STKc_PCTAIRE1 - cd07873
PTKc_Tie2 - cd05088
STKc_PCTAIRE2 - cd07872
STKc_TNIK - cd06637
PTKc_DDR2 - cd05095
PTKc_Musk - cd05050
PTKc_Csk - cd05082
PTKc_Trk - cd05049
PTKc_InsR - cd05061
PTKc_DDR - cd05051
PTKc_Frk_like - cd05068
PTKc_Lyn - cd05072
STKc_PCTAIRE_like - cd07844
PTKc_Btk_Bmx - cd05113
PKc_MKK4 - cd06616
STKc_MAPK4_6 - cd07854
STKc_ERK1_2_like - cd07849
PTKc_Chk - cd05083
STKc_PCTAIRE3 - cd07871
STKc_PFTAIRE2 - cd07870
STKc_CDK12 - cd07864
PTKc_EphR - cd05033
PTKc_Jak_rpt2 - cd05038
PTKc_InsR_like - cd05032
PTKc_Jak2_Jak3_rpt2 - cd05081
PTKc_FGFR - cd05053
PTKc_Tec_like - cd05059
PTKc_Tyk2_rpt2 - cd05080
PTKc_EphR_A - cd05066
PTKc_Jak1_rpt2 - cd05079
PTKc_EphR_B - cd05065
STKc_STK25-YSK1 - cd06642
STKc_NLK - cd07853
STKc_MST3 - cd06641
PKc_MAPKK_PBS2_like - cd06622
STKc_MST4 - cd06640
PTKc_EphR_A2 - cd05063
PTKc_TrkB - cd05093
PTKc_TrkA - cd05092
PTKc_Ror1 - cd05090
STKc_CDKL2_3 - cd07846
STKc_Nek8 - cd08220
STKc_CDKL1_4 - cd07847
STKc_SLK_like - cd06611
PTKc_Srm_Brk - cd05148
PTK_Ryk - cd05043
PTKc_Src_like - cd05034
PTKc_Fyn_Yrk - cd05070
PTKc_Ror - cd05048
PTKc_Csk_like - cd05039
PTKc_Abl - cd05052
PTKc_IGF-1R - cd05062
PTKc_FAK - cd05056
STKc_GRK6 - cd05630
STKc_GRK4_like - cd05605
PKc_MKK5 - cd06619
STKc_Nek9 - cd08221
STKc_PKN - cd05589
PK_STRAD - cd08216
STKc_GRK5 - cd05632
PTKc_Hck - cd05073
PTKc_Yes - cd05069
PTKc_DDR1 - cd05096
PTKc_Src - cd05071
PTKc_Lck_Blk - cd05067
PTKc_Tec_Rlk - cd05114
STKc_MEKK3_like_1 - cd06653
SPS1 - COG0515
STKc_MEKK3 - cd06651
STKc_Cdc7_like - cd06627
STKc_MAPKKK - cd06606
STKc_MEKK3_like - cd06625
Pkinase_Tyr - pfam07714
STYKc - smart00221
TyrKc - smart00219
STKc_CDC2L1 - cd07843
Pkinase - pfam00069
STKc_CDK8_like - cd07842
STKc_Nek11 - cd08222
STKc_Nek1 - cd08218
STKc_Nek4 - cd08223
STKc_Pho85 - cd07836
STKc_MAPKKK_Bck1_lik - cd06629
STKc_CDK7 - cd07841
PTKc_RET - cd05045
STKc_CDK4_6_like - cd07838
STKc_MAPKKK_Byr2_lik - cd06628
STKc_Nek7 - cd08229
STKc_Nek6 - cd08228
PTKc_Tie1 - cd05089
PTKc_Tyro3 - cd05074
PKc_STE - cd05122
PTKc_Axl_like - cd05035
STKc_CCRK - cd07832
PTKc_Axl - cd05075
STKc_MAK_like - cd07830
STKc_MEKK4 - cd06626
STKc_YSK4 - cd06631
STKc_MEKK1 - cd06630
STKc_MEKK2 - cd06652
STKc_MEKK1_plant - cd06632
STKc_CDK1_like - cd07835
STKc_CdkB_plant - cd07837
STKc_MAPK - cd07834
STKc_CDK5 - cd07839
STKc_CDK9_like - cd07840
STKc_CDK_like - cd07829
STKc_CDK2_3 - cd07860
STKc_MST3_like - cd06609
STKc_MOK - cd07831
STKc_CDKL - cd07833
PKc_MAPKK_Pek1_like - cd06621
STKc_Nek10 - cd08528
STKc_FA2-like - cd08529
STKc_CNK2-like - cd08530
STKc_Nek5 - cd08225
STKc_Nek3 - cd08219
STKc_CDK1_euk - cd07861
STKc_Nek - cd08215
STKc_Nek2 - cd08217
STKc_CDK4 - cd07863
PTKc_Tie - cd05047
PTKc_Met_Ron - cd05058
PTK_Jak2_Jak3_rpt1 - cd05078
PTKc_Fes - cd05084
PTKc_Fer - cd05085
PTKc_c-ros - cd05044
PTKc_Aatyk - cd05042
PTKc_Ack_like - cd05040
PTK_Jak_rpt1 - cd05037
PKc_MKK3_6 - cd06617
PTKc - cd00192
PTKc_Aatyk2 - cd05086
PTKc_Aatyk1_Aatyk3 - cd05087
PKc_MAPKK - cd06605
STKc_OSR1_SPAK - cd06610
STKc_MAP4K3_like - cd06613
PKc_MEK - cd06615
STKc_PKB_alpha - cd05594
STKc_MSK_N - cd05583
PTKc_Syk_like - cd05060
PTKc_Syk - cd05116
STKc_CMGC - cd05118
STKc_PKB - cd05571
PTKc_Fes_like - cd05041
STKc_nPKC_theta - cd05619
STKc_MST1_2 - cd06612
PTKc_Zap-70 - cd05115
STKc_PKC - cd05570
STKc_NAK1_like - cd06917
PKc - cd00180
STKc_GRK4 - cd05631
STKc_AGC - cd05123
STKc_GRK3 - cd05633
STKc_GRK - cd05577
STKc_cGK_PKG - cd05572
STKc_GRK1 - cd05608
STKc_MAST_like - cd05579
STKc_beta_ARK - cd05606
STKc_GRK7 - cd05607
STKc_Yank1 - cd05578
S_TKc - smart00220
KIND - smart00750


Swiss-Prot Protein: Q9NWZ3
Identical to: NP_001107654, NP_057207
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Domains found on the Protein

Domain ↕CD Accession ↕E-Value ↕Start ↕End ↕
Death_Tubecd083083e-068121
Death_IRAKcd083093.9e-419101
Death_IRAK4cd087931.6e-809108
Death_IRAK-Mcd087960.000119102
Deathcd016703.8e-1318101
PTKc_Kitcd051040.00170458
PTKc_VEGFR2cd051032.8e-05101460
PTKc_VEGFR3cd051020.00034124457
STKc_JNKcd078500.00045154457
STKc_PAK5cd066583.8e-05159454
STKc_PAK6cd066595.9e-08160460
STKc_TAO1cd066355.4e-06161456
STKc_PAK1cd066544.4e-07161457
STKc_TAO3cd066332.9e-05164455
PTKc_EGFR_likecd050571.7e-08165460
STKc_PAKcd066142.9e-16166450
STKc_MAP4K4_6cd066361.3e-05166433
STKc_PAK_IIcd066481.5e-09166458
STKc_PAK2cd066556.1e-06166458
STKc_PAK3cd066567.8e-07166459
STKc_PAK4cd066575.7e-06166459
STKc_PAK_Icd066471.8e-06166459
PTK_CCK4cd050461.6e-07167456
PTKc_FGFR1cd050981.7e-06167456
STKc_myosinIIIBcd066391.2e-05168460
STKc_p38cd078519.4e-06168459
STKc_Sty1_Hog1cd078565.7e-06170432
STKc_BUR1cd078663.8e-09170431
PTKc_PDGFRcd050554.8e-06171458
PTKc_FGFR2cd051014.4e-06171460
STKc_TAOcd066073.4e-06171456
STKc_ASKcd066241.7e-08171459
STKc_myosinIIIAcd066384.3e-07171459
STKc_STK10_LOKcd066443.4e-07171460
PTKc_EphR_A10cd050641.2e-07172458
PTKc_Ror2cd050917.6e-08172457
PKc_MKK7cd066181.7e-08172460
STKc_MAP4K3cd066452.4e-07172455
STKc_MAP4K5cd066462.3e-06172455
PKc_MEK2cd066490.0004172460
STKc_TAO2cd066343.9e-06172456
STKc_CDK10cd078459.3e-10172447
PTKc_FGFR4cd050991.1e-06173460
PTKc_FGFR3cd051000.00046173436
STKc_myosinIII_likecd066081e-08173414
PTK_HER3cd051116e-08174449
PTKc_HER2cd051094.7e-06174452
STKc_MAPK15cd078522.3e-06174458
PTKc_EGFRcd051085.6e-05175460
PTKc_HER4cd051101.9e-06175458
STKc_CDK9cd078652.1e-07176430
STKc_Nek6_Nek7cd082241.2e-07177459
PTKc_ALK_LTKcd050369.9e-12178456
STKc_ROCK_NDR_likecd055738.6e-06178448
STKc_PKAcd055801.2e-05178429
STKc_CRIKcd056011.5e-05178460
STKc_PDK1cd055814.1e-10178438
STKc_PRKX_likecd056120.00024178458
PKc_MAPKK_Byr1_likecd066205.2e-10178459
PKc_MAPKK_plant_likecd066231.2e-14178452
STKc_SLKcd066432.4e-08178459
STKc_CDKL5cd078480.0002178459
PTKc_Trkcd050491.3e-13179456
PTKc_Muskcd050505.2e-11179456
PTKc_DDRcd050517.3e-10179456
PTKc_InsRcd050613.9e-08179459
PTKc_Frk_likecd050682.4e-25179457
PTKc_Lyncd050722.4e-14179457
PTKc_Cskcd050821.3e-14179457
PTKc_Tie2cd050881e-08179460
PTKc_TrkCcd050941e-07179460
PTKc_DDR2cd050951.3e-09179456
PTKc_Itkcd051124.5e-14179455
PTKc_DDR_likecd050974.4e-09179456
STKc_TNIKcd066371.1e-06179433
STKc_PCTAIRE2cd078720.00012179454
STKc_PCTAIRE1cd078734.3e-05179446
PTKc_InsR_likecd050321.1e-10180456
PTKc_Jak_rpt2cd050383.2e-12180454
PTKc_FGFRcd050533.6e-09180459
PTKc_Tec_likecd050595.5e-13180455
PTKc_EphR_Bcd050656.2e-08180458
PTKc_EphR_Acd050664.6e-07180458
PTKc_EphRcd050331.5e-11180458
PTKc_Jak1_rpt2cd050799.1e-06180458
PTKc_Tyk2_rpt2cd050806.9e-09180459
PTKc_Jak2_Jak3_rpt2cd050812.2e-09180458
PTKc_Chkcd050831.9e-20180457
PTKc_Btk_Bmxcd051131.1e-10180455
PKc_MKK4cd066166.2e-08180454
STKc_PCTAIRE_likecd078441.3e-06180458
STKc_MAPK4_6cd078540.00035180458
STKc_CDK12cd078643.2e-09180437
STKc_PFTAIRE2cd078704.7e-06180458
STKc_PCTAIRE3cd078711.1e-05180455
STKc_ERK1_2_likecd078493.3e-05180460
PTKc_EphR_A2cd050638.3e-13181458
PKc_MAPKK_PBS2_likecd066226.6e-06181440
STKc_MST4cd066401.8e-07181458
STKc_MST3cd066413.1e-07181458
STKc_STK25-YSK1cd066422e-08181446
STKc_NLKcd078530.00095181460
PTKc_Src_likecd050343e-16182413
PTKc_Csk_likecd050391.5e-15182457
PTK_Rykcd050430.00033182403
PTKc_Rorcd050486.6e-13182457
PTKc_Ablcd050526.7e-15182458
PTKc_FAKcd050569.5e-07182460
PTKc_IGF-1Rcd050622.3e-08182456
PTKc_Fyn_Yrkcd050703.3e-13182457
PTKc_Ror1cd050909.1e-10182457
PTKc_TrkAcd050926e-09182456
PTKc_TrkBcd050931.8e-08182460
PTKc_Srm_Brkcd051483.5e-11182457
STKc_SLK_likecd066112.6e-08182456
STKc_CDKL2_3cd078466.1e-08182459
STKc_CDKL1_4cd078478.6e-09182459
STKc_Nek8cd082201.9e-06182454
PTKc_Lck_Blkcd050678.7e-20183457
PTKc_Yescd050695.6e-11183457
PTKc_Hckcd050732.4e-11183457
PTKc_Srccd050711.1e-09183459
PTKc_Tec_Rlkcd051143.1e-11183455
PTKc_DDR1cd050962.6e-07183456
STKc_PKNcd055890.00036183460
STKc_GRK4_likecd056051.7e-06183460
STKc_GRK6cd056300.0002183460
STKc_GRK5cd056322.1e-05183460
PKc_MKK5cd066190.00059183458
PK_STRADcd082161.6e-06183456
STKc_Nek9cd082214.6e-08183455
STKc_MAPKKKcd066061.1e-20184459
STKc_MEKK3_likecd066251.6e-13184459
STKc_Cdc7_likecd066277.4e-15184405
STKc_MEKK3cd066511.1e-09184433
STKc_MEKK3_like_1cd066537.2e-08184434
SPS1COG05157.2e-17184460
STKc_CDK8_likecd078427.4e-06186446
STKc_CDC2L1cd078436.4e-07186440
PTKc_RETcd050453.6e-08187460
STKc_MAPKKK_Byr2_likcd066281.6e-15187437
STKc_MAPKKK_Bck1_likcd066292.1e-10187429
STKc_Pho85cd078362.2e-07187459
STKc_CDK4_6_likecd078380.00011187414
STKc_CDK7cd078411.4e-11187445
STKc_Nek1cd082181.8e-05187454
STKc_Nek11cd082223.9e-06187437
STKc_Nek4cd082236.2e-06187458
PTKc_Axl_likecd050352.9e-08189458
PTKc_Tyro3cd050748.5e-06189458
PTKc_Axlcd050752.1e-05189458
PTKc_Tie1cd050892.4e-08189460
PKc_STEcd051229.7e-16189458
STKc_MEKK4cd066264.2e-11189399
STKc_MEKK1cd066305.5e-09189458
STKc_YSK4cd066311.3e-10189437
STKc_MEKK1_plantcd066322.5e-12189432
STKc_MEKK2cd066527.2e-07189432
STKc_MAK_likecd078306.2e-10189455
STKc_CCRKcd078322.2e-11189459
STKc_Nek6cd082282e-06189459
STKc_Nek7cd082296.8e-07189459
PTKccd001924.5e-33190455
PTK_Jak_rpt1cd050370.00021190458
PTKc_Ack_likecd050405.7e-14190456
PTKc_Fes_likecd050413.8e-16190456
PTKc_Aatykcd050429.6e-07190456
PTKc_c-roscd050442.9e-09190456
PTKc_Tiecd050471.7e-09190459
PTKc_Met_Roncd050581.1e-12190460
PTK_Jak2_Jak3_rpt1cd050785.9e-06190455
PTKc_Fescd050847.4e-13190456
PTKc_Fercd050852e-09190456
PTKc_Aatyk2cd050860.00053190456
PTKc_Aatyk1_Aatyk3cd050870.00016190456
PTKc_Syk_likecd050601.9e-09190459
PTKc_Sykcd051164.6e-07190459
STKc_CMGCcd051181.9e-11190455
STKc_PKBcd055719.6e-05190460
STKc_MSK_Ncd055830.00028190445
STKc_PKB_alphacd055940.00065190459
PKc_MAPKKcd066054.2e-12190452
STKc_OSR1_SPAKcd066102.4e-13190459
STKc_MAP4K3_likecd066137e-13190458
PKc_MEKcd066151.5e-08190457
PKc_MKK3_6cd066175.5e-08190456
PKc_MAPKK_Pek1_likecd066211.4e-11190454
STKc_MST3_likecd066092e-11190418
STKc_CDK_likecd078292.5e-11190431
STKc_MOKcd078319e-05190431
STKc_CDKLcd078332.9e-08190459
STKc_MAPKcd078349.4e-07190457
STKc_CDK1_likecd078354.1e-07190458
STKc_CdkB_plantcd078371.1e-07190456
STKc_CDK9_likecd078407.8e-12190440
STKc_CDK5cd078397.8e-06190459
STKc_CDK2_3cd078603e-06190458
STKc_CDK4cd078630.00052190458
STKc_CDK1_eukcd078618.5e-06190456
STKc_Nekcd082153.2e-15190456
STKc_Nek2cd082171.6e-07190456
STKc_Nek3cd082191e-06190437
STKc_Nek5cd082252.1e-05190447
STKc_Nek10cd085285e-06190456
STKc_FA2-likecd085293.8e-11190459
STKc_CNK2-likecd085309e-08190459
PTKc_Zap-70cd051151.6e-06191459
STKc_nPKC_thetacd056190.00013191460
STKc_MST1_2cd066122e-13191399
PKccd001804.5e-72192457
STKc_AGCcd051231.1e-08192453
STKc_PKCcd055701.4e-05192458
STKc_cGK_PKGcd055721.4e-06192424
STKc_GRKcd055773.3e-07192446
STKc_MAST_likecd055792e-11192423
STKc_beta_ARKcd056062.6e-05192460
STKc_GRK7cd056071.6e-05192449
STKc_GRK1cd056081.2e-07192460
STKc_GRK4cd056311.4e-05192460
STKc_GRK3cd056330.00011192450
STKc_NAK1_likecd069173.7e-10192437
STKc_Yank1cd055785e-09193454
Pkinasepfam000695.5e-46186454
Pkinase_Tyrpfam077149.1e-42185454
TyrKcsmart002199.4e-44186454
STYKcsmart002217e-47186456
S_TKcsmart002207.9e-46196458
KINDsmart007504.4e-05268460

Table of Mutations found on the Protein

Source ↕Mut_ID ↕Class ↕HGVS ↕Disease ↕
dbSNPrs4251545 Polymorphismp.ALA428THRN/A
Swiss-ProtVAR_040590Polymorphismp.ARG391HISN/A
Swiss-ProtVAR_019355Polymorphismp.HIS390ARGN/A
Swiss-ProtVAR_040588Polymorphismp.ILE5VALN/A
Swiss-ProtVAR_040589Polymorphismp.MET355VALN/A
Swiss-ProtVAR_019354Polymorphismp.SER98ARGN/A
OMIM606883.0006 Diseasep.ARG12CYSIRAK4 DEFICIENCY
OMIM606883.0002 Diseasep.GLN293TERIRAK4 DEFICIENCY



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