Results for the protein: NP

Results for the Protein: NP_001007793

56118210

4914

NTRK1

NCBI

high affinity nerve growth factor receptor isoform 3 [Homo sapiens]

Known Diseases associated with this Protein:
INSENSITIVITY TO PAIN, CONGENITAL, WITH ANHIDROSIS
THYROID CARCINOMA, FAMILIAL MEDULLARY

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Tips:

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RefSeq Protein: NP_001007793

Default View:

Domains found on the Protein

Domain ↕	CD Accession ↕	E-Value ↕	Start ↕	End ↕
Ig_TrKABC_d5	cd04971	9.3e-52	269	349
Ig_TrkB_d5	cd05855	3.1e-34	269	349
PTKc_PDGFR_alpha	cd05105	3.1e-17	428	751
PTKc_PDGFR_beta	cd05107	5e-22	443	750
PTKc_Kit	cd05104	4.2e-30	449	748
PTKc_CSF-1R	cd05106	1.8e-37	449	750
PTKc_PDGFR	cd05055	1.3e-28	450	749
STKc_PAK_I	cd06647	0.00096	451	760
STKc_PAK	cd06614	1.7e-11	455	759
STKc_TAO	cd06607	0.00047	457	756
PTKc_FGFR1	cd05098	6.6e-56	458	753
STKc_PAK_II	cd06648	2.4e-06	458	759
PTKc_FGFR2	cd05101	7.4e-53	459	753
STKc_PAK6	cd06659	5.4e-05	459	759
PTKc_FGFR4	cd05099	2.6e-58	461	758
PTKc_FGFR3	cd05100	2.7e-40	461	758
STKc_myosinIIIA	cd06638	0.00029	461	745
STKc_CDK12	cd07864	2.3e-08	461	756
STKc_BUR1	cd07866	3.3e-07	461	735
PKc_MKK7	cd06618	2.6e-05	463	751
STKc_TAO2	cd06634	0.00047	463	757
PTK_Tyk2_rpt1	cd05076	3.4e-06	464	746
STKc_ASK	cd06624	2.5e-07	465	747
PTKc_VEGFR	cd05054	3.3e-34	466	752
PTKc_Tie2	cd05088	1.1e-42	466	758
PTKc_VEGFR3	cd05102	5.6e-36	466	752
PTKc_VEGFR2	cd05103	1.9e-33	466	752
PTKc_EGFR	cd05108	1.7e-22	466	760
PTKc_HER2	cd05109	9.2e-41	466	759
PTKc_HER4	cd05110	1e-25	466	760
PTK_HER3	cd05111	2e-39	466	759
STKc_SLK	cd06643	5e-06	466	751
STKc_STK10_LOK	cd06644	2.5e-05	466	753
PTKc_InsR_like	cd05032	4.2e-98	467	747
PTKc_Src_like	cd05034	2.9e-67	467	748
PTKc_ALK_LTK	cd05036	2.4e-91	467	747
PTKc_Csk_like	cd05039	3.4e-39	467	748
PTKc_Abl	cd05052	1.2e-72	467	749
PTKc_FAK	cd05056	8.9e-77	467	753
PTKc_InsR	cd05061	8.6e-77	467	760
PTKc_Lck_Blk	cd05067	6.5e-49	467	748
PTKc_Frk_like	cd05068	1e-72	467	748
PTKc_Yes	cd05069	2.5e-42	467	748
PTKc_Fyn_Yrk	cd05070	7.4e-49	467	748
PTKc_Src	cd05071	8.6e-44	467	750
PTKc_Lyn	cd05072	2.5e-54	467	748
PTKc_Hck	cd05073	1.3e-50	467	748
PTKc_Csk	cd05082	1.7e-51	467	748
PTKc_Chk	cd05083	1.4e-56	467	748
PTKc_IGF-1R	cd05062	1e-76	467	747
STKc_Yank1	cd05578	5e-06	467	751
STKc_CDK9	cd07865	6.3e-05	467	756
STKc_MAPK15	cd07852	6.7e-05	467	759
PTK_CCK4	cd05046	7.8e-72	468	747
PTKc_Ror	cd05048	2.6e-116	468	748
PTKc_Trk	cd05049	2.3e-219	468	747
PTKc_Musk	cd05050	1.6e-127	468	747
PTKc_DDR	cd05051	4.4e-101	468	747
PTKc_EGFR_like	cd05057	1.6e-54	468	759
PTKc_EphR_A2	cd05063	3e-63	468	749
PTKc_EphR_A10	cd05064	3.7e-55	468	749
PTKc_Ror1	cd05090	4.7e-92	468	748
PTKc_Ror2	cd05091	3e-78	468	748
PTKc_TrkA	cd05092	2.6e-241	468	747
PTKc_TrkB	cd05093	1e-205	468	757
PTKc_TrkC	cd05094	7.8e-191	468	757
PTKc_DDR2	cd05095	2e-87	468	747
PTKc_DDR1	cd05096	3.7e-80	468	747
PTKc_DDR_like	cd05097	2.3e-83	468	747
PKc_MAPKK_Byr1_like	cd06620	2.7e-08	468	751
STKc_MAP4K5	cd06646	0.00027	468	746
STKc_MAP4K3	cd06645	0.00048	468	746
STKc_PCTAIRE_like	cd07844	0.00016	468	756
STKc_PFTAIRE2	cd07870	0.00025	468	756
STKc_PCTAIRE3	cd07871	0.00024	468	756
PTKc_EphR	cd05033	2.6e-68	469	749
PTKc_Jak_rpt2	cd05038	4e-67	469	749
PTK_Ryk	cd05043	1.6e-25	469	745
PTKc_FGFR	cd05053	2.1e-66	469	746
PTKc_Tec_like	cd05059	2.8e-68	469	746
PTKc_EphR_B	cd05065	3.3e-58	469	749
PTKc_EphR_A	cd05066	4.2e-64	469	749
PTKc_Jak1_rpt2	cd05079	2.6e-42	469	749
PTKc_Tyk2_rpt2	cd05080	7.7e-40	469	750
PTKc_Jak2_Jak3_rpt2	cd05081	6.4e-50	469	749
PTKc_Itk	cd05112	1.5e-64	469	746
PTKc_Btk_Bmx	cd05113	2e-69	469	746
PTKc_Tec_Rlk	cd05114	1.5e-64	469	746
PKc_MKK4	cd06616	0.00026	469	759
STKc_MAP4K3_like	cd06613	7.2e-09	470	742
STKc_MST4	cd06640	0.00038	470	759
STKc_MST3	cd06641	0.00017	470	759
STKc_STK25-YSK1	cd06642	6.5e-05	470	760
STKc_CDK10	cd07845	1e-06	470	722
STKc_CDKL1_4	cd07847	0.00011	470	747
PTKc_Srm_Brk	cd05148	1.2e-64	471	748
STKc_MEKK2	cd06652	5e-06	471	748
STKc_CDK4	cd07863	8.5e-05	471	756
STKc_Nek6_Nek7	cd08224	1.5e-07	471	750
PTKc_Tie1	cd05089	2.8e-48	472	757
STKc_PKA	cd05580	9e-05	472	758
STKc_PDK1	cd05581	6.4e-11	472	756
STKc_PRKX_like	cd05612	9.6e-05	472	760
PKc_MAPKK	cd06605	2.9e-06	472	757
STKc_myosinIII_like	cd06608	1.2e-05	472	745
STKc_OSR1_SPAK	cd06610	4.5e-08	472	739
PKc_MKK3_6	cd06617	0.00024	472	747
PKc_MEK	cd06615	5.7e-06	472	759
PKc_MAPKK_PBS2_like	cd06622	7.7e-05	472	759
PKc_MAPKK_Pek1_like	cd06621	1.9e-05	472	728
PKc_MAPKK_plant_like	cd06623	1.2e-13	472	743
STKc_CDK7	cd07841	1.5e-08	472	749
STKc_CDK6	cd07862	0.00074	472	759
STKc_Nek1	cd08218	3e-06	472	747
STKc_Nek3	cd08219	1.4e-10	472	747
STKc_Nek5	cd08225	1.2e-06	472	747
STKc_Nek6	cd08228	1.9e-06	472	750
STKc_Nek7	cd08229	4.6e-07	472	747
STKc_CNK2-like	cd08530	2.8e-08	472	745
SPS1	COG0515	1.9e-05	472	760
PTKc_RET	cd05045	3.7e-58	473	752
PKc_STE	cd05122	3.2e-13	473	744
STKc_MSK_N	cd05583	0.00062	473	757
STKc_GRK4_like	cd05605	0.00037	473	758
STKc_MST3_like	cd06609	9.1e-08	473	756
STKc_MST1_2	cd06612	2.6e-09	473	738
STKc_Cdc7_like	cd06627	1.5e-13	473	738
STKc_MAPK	cd07834	6.5e-06	473	757
STKc_Pho85	cd07836	5.9e-05	473	745
STKc_MOK	cd07831	8.6e-05	473	745
STKc_CdkB_plant	cd07837	1.9e-07	473	746
STKc_CDK1_euk	cd07861	0.00061	473	756
STKc_Nek	cd08215	1e-13	473	747
STKc_Nek2	cd08217	4.7e-08	473	745
STKc_Nek11	cd08222	3.1e-07	473	747
STKc_Nek4	cd08223	3.3e-07	473	747
STKc_FA2-like	cd08529	2.4e-09	473	738
STKc_Nek10	cd08528	0.00017	473	747
PTKc_Axl_like	cd05035	1.1e-58	474	749
PTKc_Tyro3	cd05074	2.5e-56	474	749
PTKc_Axl	cd05075	1.7e-51	474	749
STKc_CDK2_3	cd07860	0.00064	474	756
STKc_MAK_like	cd07830	4.3e-10	475	747
STKc_CDK1_like	cd07835	7.1e-06	475	756
STKc_RSK_N	cd05582	0.00014	476	758
STKc_MEKK3_like	cd06625	1.1e-11	476	747
STKc_MAPKKK_Bck1_lik	cd06629	2.8e-11	476	743
STKc_MEKK3	cd06651	3.5e-09	476	749
STKc_MEKK3_like_1	cd06653	3.9e-07	476	748
STKc_MAPKKK	cd06606	6.8e-19	477	745
STKc_MEKK4	cd06626	3.3e-09	477	743
STKc_MAPKKK_Byr2_lik	cd06628	3.6e-12	477	747
STKc_MEKK1	cd06630	1.6e-07	477	746
STKc_YSK4	cd06631	2.8e-09	477	745
STKc_MEKK1_plant	cd06632	1.4e-10	477	741
STKc_NAK1_like	cd06917	2.9e-07	477	746
STKc_CDK5	cd07839	2.5e-05	477	745
STKc_CDKL2_3	cd07846	3.4e-05	477	745
STKc_Nek8	cd08220	1.9e-06	477	749
PTKc	cd00192	8.6e-131	478	746
PTK_Jak_rpt1	cd05037	3.1e-12	478	746
PTKc_Ack_like	cd05040	7.6e-63	478	747
PTKc_Fes_like	cd05041	2.7e-55	478	747
PTKc_Aatyk	cd05042	1.4e-35	478	747
PTKc_Syk_like	cd05060	1.9e-57	478	750
PTKc_Syk	cd05116	7.2e-49	478	750
PTK_Jak1_rpt1	cd05077	5e-08	479	746
PTK_Jak2_Jak3_rpt1	cd05078	1.4e-12	479	742
PTKc_Aatyk2	cd05086	1.4e-39	479	747
PTKc_Aatyk1_Aatyk3	cd05087	6.9e-45	479	747
PTKc_Fes	cd05084	1.8e-64	479	747
PTKc_Zap-70	cd05115	2e-52	479	750
STKc_CMGC	cd05118	1.1e-07	479	745
STKc_SLK_like	cd06611	9.2e-08	479	751
STKc_CDK_like	cd07829	2e-10	479	745
STKc_CDKL	cd07833	9.2e-06	479	745
STKc_CDK9_like	cd07840	2.5e-10	479	759
STKc_CDK8_like	cd07842	5.5e-05	479	743
STKc_CDC2L1	cd07843	0.00014	479	756
STKc_CDK4_6_like	cd07838	5.3e-06	479	756
PKc	cd00180	8.1e-60	480	745
PTKc_c-ros	cd05044	3.8e-83	480	747
PTKc_Tie	cd05047	2.3e-54	480	750
PTKc_Met_Ron	cd05058	8.1e-61	480	751
PTKc_Fer	cd05085	7.5e-54	480	747
STKc_AGC	cd05123	6.2e-08	480	743
STKc_PKC	cd05570	4.3e-05	480	756
STKc_cGK_PKG	cd05572	2.4e-07	480	743
STKc_GRK	cd05577	0.00065	480	757
STKc_MAST_like	cd05579	2.8e-09	480	743
STKc_nPKC_theta	cd05619	0.001	480	758
STKc_CCRK	cd07832	8.8e-09	480	746
STKc_Nek9	cd08221	2.2e-08	480	747
Pkinase	pfam00069	5.8e-43	474	745
LRRCT	smart00082	1.2e-09	118	162
I-set	pfam07679	0.00026	164	252
Pkinase_Tyr	pfam07714	2.1e-138	474	745
TyrKc	smart00219	2e-135	474	745
STYKc	smart00221	1.1e-50	474	756
S_TKc	smart00220	2.8e-44	484	754
KIND	smart00750	0.00014	579	755

Table of Mutations found on the Protein

Source ↕	Mut_ID ↕	Class ↕	HGVS ↕	Disease ↕
dbSNP	rs6339	Polymorphism	p.GLY577VAL	N/A
dbSNP	rs6336	Polymorphism	p.HIS568TYR	N/A
OMIM	191315.0004	Disease	p.ARG738PRO	INSENSITIVITY TO PAIN, CONGENITAL, WITH ANHIDROSIS
OMIM	191315.0003	Disease	p.GLY535ARG	INSENSITIVITY TO PAIN, CONGENITAL, WITH ANHIDROSIS
OMIM	191315.0013	Disease	p.MET545VAL	INSENSITIVITY TO PAIN, CONGENITAL, WITH ANHIDROSIS
OMIM	191315.0011	Disease	p.PRO653LEU	INSENSITIVITY TO PAIN, CONGENITAL, WITH ANHIDROSIS
OMIM	191315.0012	Disease	p.TYR329CYS	INSENSITIVITY TO PAIN, CONGENITAL, WITH ANHIDROSIS
OMIM	191315.0008	Disease	p.TYR568HIS	THYROID CARCINOMA, FAMILIAL MEDULLARY
OMIM	191315.0009	Disease	p.VAL577GLY	THYROID CARCINOMA, FAMILIAL MEDULLARY

Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

DMDM_info@umbc.edu | 1000 Hilltop Circle, Baltimore, MD 21250 | Department of Biological Sciences | Phone: 410-455-2258