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Results for the Protein: P29597
56405328

TYK2_HUMAN RecName: Full=Non-receptor tyrosine-protein kinase TYK2
0
15
0
4
11
Tips:
 The Domains on the Default View are decided by the Domain's E-Value.

 Clicking a check box will display or hide the correlated domain.

 To view the Gene page, either click on the link to the left or the blue bar above the Protein's graphic.



Default View:

B41 - smart00295
SH2 - smart00252
SH2 - cd00173
PTKc_Frk_like - cd05068
PTKc_FAK - cd05056
PTKc_Abl - cd05052
PTKc_InsR - cd05061
PTKc_EphR_A2 - cd05063
PTKc_EphR_A10 - cd05064
PTKc_Tec_Rlk - cd05114
PTKc_EphR_A - cd05066
PTKc_EphR_B - cd05065
PTKc_Btk_Bmx - cd05113
Pkinase_Tyr - pfam07714
TyrKc - smart00219
PTKc_Chk - cd05083
STYKc - smart00221
PTKc_Syk - cd05116
PTKc - cd00192
PTK_Tyk2_rpt1 - cd05076
PTK_Jak_rpt1 - cd05037
PTK_Jak2_Jak3_rpt1 - cd05078
PTK_Jak1_rpt1 - cd05077
PTKc_Fer - cd05085
PTKc_Fes - cd05084
PKc - cd00180
PTKc_Lck_Blk - cd05067
PTKc_Hck - cd05073
PTKc_Tyro3 - cd05074
PTKc_Met_Ron - cd05058
PTKc_Csk - cd05082
PTKc_Zap-70 - cd05115
PTKc_Itk - cd05112
S_TKc - smart00220
PTKc_PDGFR_beta - cd05107
PTKc_Kit - cd05104
PTKc_VEGFR - cd05054
PTKc_PDGFR_alpha - cd05105
PTKc_CSF-1R - cd05106
STKc_PAK6 - cd06659
STKc_PAK4 - cd06657
STKc_PAK5 - cd06658
STKc_PAK2 - cd06655
STKc_MAP4K4_6 - cd06636
STKc_PAK_II - cd06648
STKc_myosinIIIB - cd06639
STKc_PAK_I - cd06647
PKc_MKK5 - cd06619
STKc_PAK - cd06614
STKc_MAP4K5 - cd06646
PKc_MKK7 - cd06618
PTKc_PDGFR - cd05055
STKc_TAO3 - cd06633
STKc_TAO1 - cd06635
PTKc_FGFR1 - cd05098
PTKc_FGFR2 - cd05101
STKc_MAP4K3 - cd06645
PTKc_DDR - cd05051
STKc_CDK9 - cd07865
PTKc_FGFR3 - cd05100
PTKc_FGFR4 - cd05099
STKc_myosinIIIA - cd06638
PTKc_FGFR - cd05053
STKc_myosinIII_like - cd06608
STKc_TNIK - cd06637
STKc_PAK1 - cd06654
STKc_PAK3 - cd06656
STKc_TAO2 - cd06634
STKc_TAO - cd06607
STKc_MAPK15 - cd07852
STKc_BUR1 - cd07866
STKc_MEKK2 - cd06652
PTK_HER3 - cd05111
STKc_CDK10 - cd07845
PTKc_EGFR_like - cd05057
STKc_Sty1_Hog1 - cd07856
PTKc_Tie2 - cd05088
PTK_Ryk - cd05043
PTKc_EGFR - cd05108
PTKc_HER2 - cd05109
STKc_ASK - cd06624
PTKc_ALK_LTK - cd05036
PTKc_HER4 - cd05110
PTKc_Ror - cd05048
PTKc_Trk - cd05049
PTKc_Csk_like - cd05039
PTKc_DDR1 - cd05096
PTK_CCK4 - cd05046
STKc_SLK - cd06643
STKc_Nek6 - cd08228
STKc_Nek7 - cd08229
PTKc_DDR_like - cd05097
PTKc_VEGFR3 - cd05102
PTKc_DDR2 - cd05095
PTKc_VEGFR2 - cd05103
STKc_PCTAIRE2 - cd07872
STKc_PCTAIRE1 - cd07873
STKc_PCTAIRE3 - cd07871
PTKc_TrkC - cd05094
STKc_CDK12 - cd07864
STKc_p38 - cd07851
STKc_STK10_LOK - cd06644
STKc_ERK1_2_like - cd07849
PKc_MKK4 - cd06616
PTKc_TrkA - cd05092
PTKc_IGF-1R - cd05062
PTKc_Tec_like - cd05059
PTKc_InsR_like - cd05032
PTKc_EphR - cd05033
PTKc_Jak_rpt2 - cd05038
PTKc_Musk - cd05050
PTKc_Src - cd05071
PTKc_Jak1_rpt2 - cd05079
PTKc_Tyk2_rpt2 - cd05080
PTKc_Jak2_Jak3_rpt2 - cd05081
PTKc_Lyn - cd05072
PTKc_Yes - cd05069
PTKc_Fyn_Yrk - cd05070
STKc_PCTAIRE_like - cd07844
PTKc_TrkB - cd05093
STKc_PFTAIRE2 - cd07870
STKc_MAP4K3_like - cd06613
STKc_Yank1 - cd05578
STKc_CDKL1_4 - cd07847
STKc_CDKL2_3 - cd07846
STKc_CdkB_plant - cd07837
SPS1 - COG0515
STKc_Nek6_Nek7 - cd08224
PTKc_Src_like - cd05034
STKc_OSR1_SPAK - cd06610
STKc_ROCK_NDR_like - cd05573
PTKc_Ror2 - cd05091
PTKc_RET - cd05045
STKc_MST4 - cd06640
PTKc_Ror1 - cd05090
STKc_MEKK3_like_1 - cd06653
STKc_CDKL - cd07833
STKc_MST3 - cd06641
STKc_STK25-YSK1 - cd06642
STKc_Nek - cd08215
STKc_MAPK4_6 - cd07854
STKc_Nek1 - cd08218
STKc_CDK4 - cd07863
STKc_Nek11 - cd08222
STKc_CDK8_like - cd07842
STKc_Nek4 - cd08223
STKc_Nek9 - cd08221
STKc_Nek8 - cd08220
STKc_Nek5 - cd08225
STKc_PRKX_like - cd05612
STKc_LATS - cd05598
PKc_MAPKK - cd06605
STKc_MST3_like - cd06609
STKc_CDK7 - cd07841
PKc_MEK - cd06615
STKc_phototropin_lik - cd05574
STKc_PKA - cd05580
PKc_MKK3_6 - cd06617
STKc_CCRK - cd07832
STKc_CDK5 - cd07839
PKc_MAPKK_plant_like - cd06623
STKc_NAK1_like - cd06917
STKc_Cdc7_like - cd06627
PKc_MAPKK_Pek1_like - cd06621
STKc_Pho85 - cd07836
STKc_CDK2_3 - cd07860
STKc_CDK1_euk - cd07861
STKc_Nek3 - cd08219
STKc_MPK1 - cd07857
STKc_YSK4 - cd06631
STKc_MSK1_N - cd05613
STKc_cPKC_alpha - cd05615
STKc_GRK4_like - cd05605
STKc_MSK_N - cd05583
PKc_STE - cd05122
STKc_MAPK - cd07834
STKc_GRK6 - cd05630
STKc_MAPKKK - cd06606
STKc_MEKK3 - cd06651
STKc_GRK4 - cd05631
STKc_GRK5 - cd05632
STKc_CDK1_like - cd07835
STKc_CDK4_6_like - cd07838
Pkinase - pfam00069
STKc_CDK9_like - cd07840
PTKc_Axl - cd05075
STKc_MEKK4 - cd06626
STKc_cPKC - cd05587
STKc_PKN - cd05589
STKc_CMGC - cd05118
PKc_MAPKK_PBS2_like - cd06622
PKc_MAPKK_Byr1_like - cd06620
STKc_CDK_like - cd07829
STKc_MAK_like - cd07830
PTKc_Axl_like - cd05035
STKc_cPKC_beta - cd05616
STKc_MOK - cd07831
STKc_Nek2 - cd08217
STKc_MEKK3_like - cd06625
STKc_PDK1 - cd05581
STKc_MAPKKK_Byr2_lik - cd06628
STKc_MEKK1 - cd06630
STKc_MEKK1_plant - cd06632
PK_STRAD - cd08216
STKc_CRIK - cd05601
PTKc_Tie1 - cd05089
STKc_FA2-like - cd08529
STKc_SLK_like - cd06611
PTKc_Srm_Brk - cd05148
STKc_Nek10 - cd08528
STKc_RSK_N - cd05582
STKc_CNK2-like - cd08530
STKc_PKB_alpha - cd05594
STKc_nPKC_eta - cd05590
STKc_nPKC_theta - cd05619
STKc_PKB_gamma - cd05593
STKc_nPKC_epsilon - cd05591
PTKc_c-ros - cd05044
PTKc_Aatyk - cd05042
PTKc_Syk_like - cd05060
PTKc_Aatyk2 - cd05086
STKc_nPKC_theta_delt - cd05592
PTKc_Fes_like - cd05041
PTKc_Ack_like - cd05040
PTKc_Aatyk1_Aatyk3 - cd05087
STKc_PKB - cd05571
STKc_PKC - cd05570
PTKc_Tie - cd05047
STKc_GRK1 - cd05608
STKc_cGK_PKG - cd05572
STKc_AGC - cd05123
STKc_MAST_like - cd05579
STKc_GRK - cd05577
STKc_GRK7 - cd05607
STKc_MST1_2 - cd06612
STKc_beta_ARK - cd05606
STKc_MAPKKK_Bck1_lik - cd06629
STKc_CDC2L1 - cd07843
KIND - smart00750


Swiss-Prot Protein: P29597
Identical to: NP_003322
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Domains found on the Protein

Domain ↕CD Accession ↕E-Value ↕Start ↕End ↕
SH2cd001731.3e-12449551
PTKc_Ablcd050522.9e-15582870
PTKc_FAKcd050561.7e-13582874
PTKc_InsRcd050612.9e-08582879
PTKc_Frk_likecd050683e-15582869
PTKc_EphR_A10cd050641.5e-09583870
PTKc_EphR_A2cd050639.2e-08583870
PTKc_EphR_Bcd050651.3e-07584870
PTKc_EphR_Acd050666.2e-07584870
PTKc_Btk_Bmxcd051134.1e-08584867
PTKc_Tec_Rlkcd051146.7e-09584867
PTKc_Chkcd050836.8e-08589869
PTKccd001922.5e-21593867
PTK_Jak_rpt1cd050376.2e-196593867
PTK_Tyk2_rpt1cd050761e-209593867
PTK_Jak2_Jak3_rpt1cd050781.3e-103593867
PTK_Jak1_rpt1cd050776.1e-126593867
PTKc_Fescd050844.2e-09593868
PTKc_Fercd050854.2e-07593868
PTKc_Sykcd051161.8e-07593871
PKccd001803.3e-19595866
PTKc_Lck_Blkcd050675.4e-06602866
PTKc_Hckcd050731.2e-07602866
PTKc_Tyro3cd050747.8e-06603870
PTKc_Met_Roncd050581.5e-05609872
PTKc_Cskcd050824.8e-07609869
PTKc_Zap-70cd051151.5e-07610871
PTKc_Itkcd051122.9e-09615867
PTKc_PDGFR_betacd051072.2e-067431174
PTKc_Kitcd051042.2e-097691173
PTKc_VEGFRcd050541.9e-077971176
PTKc_PDGFR_alphacd051051e-098051175
PTKc_CSF-1Rcd051066.1e-078561174
STKc_PAK6cd066592.3e-068661179
STKc_PAK4cd066571.5e-058681175
STKc_PAK5cd066580.000138681152
STKc_PAK2cd066550.000128701180
STKc_MAP4K4_6cd066360.000278721169
STKc_PAK_IIcd066481.3e-068721148
STKc_myosinIIIBcd066395.2e-058741170
STKc_PAKcd066144.1e-158751183
PKc_MKK5cd066190.000968751187
STKc_PAK_Icd066476.5e-058751174
STKc_MAP4K5cd066461.5e-068761145
PTKc_PDGFRcd050551.2e-118771173
PKc_MKK7cd066183.6e-058771186
PTKc_FGFR1cd050982.7e-308791180
STKc_TAO3cd066337.9e-068791185
STKc_TAO1cd066351.4e-068791185
PTKc_FGFR2cd051012.1e-308811174
PTKc_DDRcd050513.1e-178831171
STKc_MAP4K3cd066452.1e-068831168
STKc_CDK9cd078659.1e-068831162
PTKc_FGFR4cd050996.5e-338851182
PTKc_FGFR3cd051008.9e-248851187
STKc_myosinIIIAcd066380.000238851171
PTKc_FGFRcd050531.4e-308861174
STKc_myosinIII_likecd066082.3e-098861169
STKc_TNIKcd066372.2e-058861169
STKc_PAK1cd066546.2e-058871179
STKc_TAOcd066074.8e-088881185
STKc_TAO2cd066341.6e-088881186
STKc_PAK3cd066560.000138881183
STKc_MAPK15cd078522.5e-068881187
STKc_BUR1cd078663.8e-068881162
PTKc_EGFR_likecd050579.8e-498891183
PTK_HER3cd051113.6e-368891180
STKc_MEKK2cd066521.7e-088891173
STKc_CDK10cd078458.9e-098891163
PTKc_ALK_LTKcd050361.3e-228901171
PTK_Rykcd050432.5e-168901176
PTKc_FAKcd050561.3e-528901177
PTKc_Tie2cd050881.6e-208901181
PTKc_EGFRcd051083e-268901186
PTKc_HER2cd051093.9e-338901185
PTKc_HER4cd051103.4e-278901184
STKc_ASKcd066242.6e-088901169
STKc_Sty1_Hog1cd078560.000488901183
PTKc_Csk_likecd050391.3e-238911172
PTK_CCK4cd050461.3e-168911171
PTKc_Trkcd050492.7e-348911178
PTKc_Rorcd050485.4e-248911172
PTKc_Cskcd050821.9e-438911172
PTKc_Chkcd050834.1e-488911172
PTKc_DDR1cd050961.6e-278911171
STKc_SLKcd066434.7e-078911177
STKc_Nek6cd082282.3e-058911174
STKc_Nek7cd082291.6e-078911174
PTKc_InsR_likecd050321.5e-388921171
PTKc_EphRcd050333.3e-288921173
PTKc_Jak_rpt2cd050388.8e-2088921173
PTKc_Muskcd050501.8e-258921171
PTKc_Ablcd050524e-438921173
PTKc_Tec_likecd050594.3e-228921170
PTKc_InsRcd050612.3e-258921181
PTKc_IGF-1Rcd050621.1e-258921171
PTKc_EphR_A10cd050642.5e-288921172
PTKc_EphR_Bcd050652e-228921173
PTKc_EphR_Acd050661.3e-318921173
PTKc_Lck_Blkcd050671.7e-428921172
PTKc_Frk_likecd050684.1e-568921172
PTKc_Yescd050696.4e-288921172
PTKc_Fyn_Yrkcd050701.3e-298921172
PTKc_Lyncd050728e-418921172
PTKc_Hckcd050732.2e-378921172
PTKc_Srccd050713.6e-288921174
PTKc_Jak1_rpt2cd050793.8e-1478921173
PTKc_Tyk2_rpt2cd050802.5e-2618921174
PTKc_Jak2_Jak3_rpt2cd050819.6e-1328921173
PTKc_EphR_A2cd050633.3e-318921173
PTKc_TrkAcd050921.1e-398921178
PTKc_TrkCcd050945.5e-338921186
PTKc_DDR2cd050952.9e-288921171
PTKc_VEGFR3cd051025.6e-108921176
PTKc_VEGFR2cd051037.8e-118921176
PTKc_Itkcd051122e-308921170
PTKc_Btk_Bmxcd051136.6e-408921170
PTKc_DDR_likecd050972.6e-328921171
PTKc_Tec_Rlkcd051143.2e-358921170
PKc_MKK4cd066168.3e-068921187
STKc_STK10_LOKcd066442.7e-078921186
STKc_ERK1_2_likecd078490.000118921178
STKc_p38cd078513.7e-058921181
STKc_CDK12cd078645.5e-108921183
STKc_PCTAIRE2cd078728.4e-058921187
STKc_PCTAIRE1cd078730.000158921174
STKc_PCTAIRE3cd078715.1e-058921163
PTKc_TrkBcd050931.1e-368931186
STKc_Yank1cd055786.1e-098931146
STKc_MAP4K3_likecd066131.2e-098931124
STKc_PCTAIRE_likecd078442e-068931187
STKc_PFTAIRE2cd078701e-058931187
PTKc_Src_likecd050342.8e-338941172
PTKc_RETcd050456e-318941180
PTKc_Ror1cd050905.7e-208941172
PTKc_Ror2cd050917.9e-158941172
STKc_ROCK_NDR_likecd055737.9e-068941185
STKc_OSR1_SPAKcd066102.8e-098941169
STKc_MST4cd066409.9e-078941173
STKc_STK25-YSK1cd066423.5e-088941173
STKc_MST3cd066413.1e-078941180
STKc_MEKK3_like_1cd066533.7e-108941171
STKc_CDKLcd078335.5e-108941169
STKc_CdkB_plantcd078376.4e-098941163
STKc_CDKL1_4cd078474.5e-078941171
STKc_CDKL2_3cd078465e-078941176
STKc_Nek6_Nek7cd082247.2e-088941174
SPS1COG05151.3e-138941187
STKc_phototropin_likcd055745.3e-058951151
STKc_PKAcd055805.6e-098951176
STKc_LATScd055980.000248951184
STKc_PRKX_likecd056126.7e-068951185
PKc_MAPKKcd066052.8e-098951174
STKc_MST3_likecd066098.9e-138951135
PKc_MEKcd066155.2e-068951187
PKc_MKK3_6cd066172.6e-068951186
PKc_MAPKK_Pek1_likecd066213.7e-098951187
STKc_Cdc7_likecd066278.7e-178951169
PKc_MAPKK_plant_likecd066233.5e-158951174
STKc_NAK1_likecd069175.8e-098951177
STKc_CCRKcd078323.1e-098951163
STKc_CDK5cd078394.3e-068951184
STKc_CDK7cd078418.2e-128951167
STKc_CDK8_likecd078423.5e-088951162
STKc_MAPK4_6cd078540.00018951182
STKc_CDK4cd078631.4e-058951177
STKc_Nekcd082153.4e-178951169
STKc_Nek1cd082185.6e-088951169
STKc_Nek8cd082208.9e-088951169
STKc_Nek9cd082211.1e-098951167
STKc_Nek11cd082222.3e-068951171
STKc_Nek4cd082231.3e-068951153
STKc_Nek5cd082253.1e-058951153
PKc_STEcd051227.6e-158961165
STKc_MSK_Ncd055831.3e-058961160
STKc_GRK4_likecd056052.3e-068961186
STKc_MSK1_Ncd056130.000448961160
STKc_cPKC_alphacd056150.000238961187
STKc_GRK6cd056300.000158961181
STKc_GRK4cd056316.1e-058961181
STKc_GRK5cd056322.3e-058961186
STKc_MAPKKKcd066061.5e-268961169
STKc_YSK4cd066311.3e-118961169
STKc_MEKK3cd066511.4e-128961165
STKc_MAPKcd078344.7e-078961187
STKc_Pho85cd078365.2e-078961184
STKc_CDK2_3cd078601.9e-078961177
STKc_MPK1cd078570.000198961172
STKc_CDK1_eukcd078611.4e-058961183
STKc_Nek3cd082198.2e-108961152
PTKc_Axl_likecd050351.1e-318971173
PTKc_Tyro3cd050749.5e-328971173
PTKc_Axlcd050751.7e-208971173
STKc_CMGCcd051181.8e-128971169
STKc_cPKCcd055870.00028971187
STKc_PKNcd055891.5e-068971187
STKc_cPKC_betacd056160.000818971187
PKc_MAPKK_Byr1_likecd066203.5e-078971182
PKc_MAPKK_PBS2_likecd066220.000198971187
STKc_MEKK4cd066262.7e-098971166
STKc_CDK_likecd078292e-138971162
STKc_MAK_likecd078309.8e-118971162
STKc_MOKcd078314.5e-088971162
STKc_CDK4_6_likecd078381.8e-068971134
STKc_CDK9_likecd078407.8e-118971162
STKc_CDK1_likecd078355.3e-088971183
STKc_PDK1cd055811.2e-098981128
STKc_MEKK3_likecd066252.1e-168981171
STKc_MAPKKK_Byr2_likcd066287.3e-238981169
STKc_MEKK1cd066303.5e-078981170
STKc_MEKK1_plantcd066321.5e-138981169
PK_STRADcd082168.4e-058981171
STKc_Nek2cd082171.2e-098981169
PTKc_Tie1cd050894e-208991180
STKc_CRIKcd056012.7e-058991187
STKc_FA2-likecd085295.4e-098991127
PTKc_Srm_Brkcd051484e-349001172
STKc_RSK_Ncd055820.000179001187
STKc_SLK_likecd066111.9e-079001168
STKc_CNK2-likecd085302.3e-079001169
STKc_Nek10cd085280.000179001168
PTKccd001923.5e-869011170
PTKc_Ack_likecd050401.8e-569011171
PTKc_Fes_likecd050413.6e-279011171
PTKc_Aatykcd050421.8e-129011171
PTKc_c-roscd050442e-279011171
PTKc_Met_Roncd050582.5e-459011175
PTKc_Syk_likecd050604.7e-559011174
PTKc_Fescd050841.5e-309011171
PTKc_Aatyk2cd050862.4e-119011171
PTKc_Aatyk1_Aatyk3cd050871.5e-149011171
PTKc_Sykcd051164.1e-489011174
STKc_PKCcd055702.5e-099011186
STKc_PKBcd055710.000159011187
STKc_nPKC_epsiloncd055915.1e-059011187
STKc_nPKC_theta_deltcd055924e-059011181
STKc_PKB_gammacd055930.000449011187
STKc_PKB_alphacd055940.000999011185
STKc_nPKC_etacd055900.00019011187
STKc_nPKC_thetacd056191.3e-069011181
PTKc_Tiecd050473.7e-309021174
PTKc_Zap-70cd051154e-469021174
PKccd001807.2e-549031169
PTKc_Fercd050851.1e-309031171
STKc_AGCcd051234.9e-089031136
STKc_cGK_PKGcd055724.9e-079031139
STKc_GRKcd055778.4e-069031161
STKc_MAST_likecd055798e-089031174
STKc_beta_ARKcd056060.000289031168
STKc_GRK7cd056070.000139031185
STKc_GRK1cd056083e-089031187
STKc_MST1_2cd066123e-129031112
STKc_MAPKKK_Bck1_likcd066291.7e-129041163
STKc_CDC2L1cd078434.7e-089121162
Pkinasepfam000691.4e-418971169
B41smart002958.5e-7523275
SH2smart002525.4e-10448539
Pkinase_Tyrpfam077149.9e-50589866
TyrKcsmart002191.4e-13589866
STYKcsmart002214.9e-07589868
S_TKcsmart002201.1e-09630869
Pkinase_Tyrpfam077148.9e-1358971169
TyrKcsmart002194.9e-1288971169
STYKcsmart002211.4e-508971142
S_TKcsmart002205.1e-479071169
KINDsmart007500.000939841179

Table of Mutations found on the Protein

Source ↕Mut_ID ↕Class ↕HGVS ↕Disease ↕
Swiss-ProtVAR_037797Polymorphismp.ALA81VALN/A
Swiss-ProtVAR_041873Polymorphismp.ALA928VALN/A
Swiss-ProtVAR_037796Polymorphismp.ARG4CYSN/A
Swiss-ProtVAR_037798Polymorphismp.ARG442GLNN/A
dbSNPrs12720263 Polymorphismp.ARG197HISN/A
Swiss-ProtVAR_020597Polymorphismp.ARG4HISN/A
Swiss-ProtVAR_041871Polymorphismp.ARG703TRPN/A
Swiss-ProtVAR_041875Polymorphismp.GLU1163GLYN/A
dbSNPrs2304255 Polymorphismp.GLY363SERN/A
Swiss-ProtVAR_041872Polymorphismp.HIS732ARGN/A
dbSNPrs12720356 Polymorphismp.ILE684SERN/A
Swiss-ProtVAR_041874Polymorphismp.PRO1104ALAN/A
Swiss-ProtVAR_037799Polymorphismp.PRO820HISN/A
Swiss-ProtVAR_041870Polymorphismp.VAL386METN/A
dbSNPrs2304256 Polymorphismp.VAL362PHEN/A



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