Results for the protein: NP

Results for the Protein: NP_009297

62362412

25

ABL1

NCBI

tyrosine-protein kinase ABL1 isoform b [Homo sapiens]

Known Diseases associated with this Protein:
CHRONIC MYELOID LEUKEMIA, RESISTANT TO IMATINIB
LEUKEMIA, PHILADELPHIA CHROMOSOME-POSITIVE, RESISTANT TO IMATINIB

6

1

6

1

0

Tips:

The Domains on the Default View are decided by the Domain's E-Value.

Clicking a check box will display or hide the correlated domain.

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RefSeq Protein: NP_009297

Default View:

Domains found on the Protein

Domain ↕	CD Accession ↕	E-Value ↕	Start ↕	End ↕
SH2	cd00173	5.1e-33	145	236
PTKc_CSF-1R	cd05106	6.9e-38	219	517
STKc_ROCK	cd05596	0.00084	222	556
PTKc_Kit	cd05104	1.8e-29	223	516
PTKc_PDGFR_beta	cd05107	4.3e-15	223	517
STKc_ROCK2	cd05621	0.0003	226	556
PTKc_PDGFR_alpha	cd05105	1.1e-16	234	518
STKc_TAO1	cd06635	3.6e-06	235	543
STKc_myosinIIIA	cd06638	3e-06	236	514
STKc_PAK6	cd06659	9.1e-05	236	536
STKc_TAO3	cd06633	6.5e-05	238	543
STKc_JNK2	cd07876	0.00069	238	616
STKc_TAO	cd06607	5.7e-06	241	543
STKc_JNK3	cd07874	0.00011	242	629
STKc_p38alpha_MAPK14	cd07877	1.7e-05	242	599
STKc_JNK1	cd07875	0.00064	243	618
STKc_myosinIIIB	cd06639	0.00013	244	513
STKc_BUR1	cd07866	4.5e-07	244	512
STKc_p38beta_MAPK11	cd07878	0.00029	244	557
STKc_p38gamma_MAPK12	cd07880	8.2e-05	244	557
STKc_p38	cd07851	2.2e-06	244	547
PTKc_PDGFR	cd05055	1.2e-30	245	516
PTK_Tyk2_rpt1	cd05076	8.2e-09	245	513
PTKc_FGFR2	cd05101	8.5e-58	245	523
STKc_ERK1_2_like	cd07849	7.4e-06	245	540
PTKc_FGFR1	cd05098	9.3e-58	246	523
STKc_TAO2	cd06634	6.6e-07	246	544
STKc_SLK_like	cd06611	1.4e-09	247	527
STKc_SLK	cd06643	4.9e-07	247	531
PTKc_FGFR	cd05053	1.1e-79	249	517
PTKc_FGFR4	cd05099	1.2e-60	249	539
PTKc_FGFR3	cd05100	2.6e-51	249	565
PKc_MKK7	cd06618	1.2e-10	250	531
STKc_CDK5	cd07839	1.2e-07	250	563
STKc_JNK	cd07850	3.4e-05	250	596
STKc_PCTAIRE1	cd07873	3.8e-06	250	562
STKc_PAK	cd06614	1.5e-12	251	525
STKc_PAK1	cd06654	3.1e-06	251	533
STKc_PCTAIRE3	cd07871	2.2e-07	251	564
STKc_ASK	cd06624	9.1e-09	252	514
STKc_MST4	cd06640	3.8e-08	252	533
STKc_MST3	cd06641	2.6e-08	252	533
STKc_PAK_I	cd06647	7.6e-06	252	531
STKc_PAK2	cd06655	2.8e-06	252	534
STKc_PAK3	cd06656	3.2e-06	252	535
STKc_MAPK15	cd07852	1.2e-06	252	542
STKc_CDK9	cd07865	4.6e-07	252	512
PTKc_VEGFR	cd05054	7.6e-31	253	519
PTKc_EGFR_like	cd05057	4.3e-77	253	522
PTKc_VEGFR3	cd05102	5.8e-35	253	519
PTKc_VEGFR2	cd05103	2e-28	253	519
STKc_PAK_II	cd06648	2.5e-06	253	525
PTKc_InsR_like	cd05032	2.5e-84	254	514
PTKc_Src_like	cd05034	9.7e-140	254	515
PTKc_ALK_LTK	cd05036	8.1e-72	254	514
PTKc_Csk_like	cd05039	1.2e-104	254	515
PTKc_IGF-1R	cd05062	4.7e-69	254	514
PTKc_Lck_Blk	cd05067	1e-101	254	515
PTKc_Frk_like	cd05068	1.7e-125	254	515
PTKc_Fyn_Yrk	cd05070	1e-97	254	516
PTKc_Src	cd05071	8.8e-94	254	517
PTKc_Lyn	cd05072	5e-102	254	515
PTKc_Hck	cd05073	1.3e-99	254	515
PTKc_InsR	cd05061	2.5e-64	254	521
PTKc_Yes	cd05069	7.5e-95	254	515
PTKc_Abl	cd05052	1.5e-212	254	516
PTKc_FAK	cd05056	7.4e-95	254	520
PTKc_Csk	cd05082	5.9e-88	254	515
PTKc_Chk	cd05083	1.1e-86	254	515
PTKc_Tie1	cd05089	4.1e-59	254	535
PTKc_Srm_Brk	cd05148	4.3e-109	254	515
STKc_STK10_LOK	cd06644	7.4e-07	254	534
STKc_TEY_MAPK_plant	cd07858	3.6e-05	254	585
STKc_CDK12	cd07864	4.9e-08	254	534
PTK_CCK4	cd05046	4.9e-51	255	514
PTKc_Ror	cd05048	6.2e-62	255	515
PTKc_Musk	cd05050	1.5e-79	255	514
PTKc_DDR	cd05051	2.3e-63	255	514
PTKc_EphR_A2	cd05063	1.1e-69	255	516
PTKc_EphR_A10	cd05064	4.7e-58	255	516
PTKc_Trk	cd05049	1.3e-69	255	514
PTKc_Ror1	cd05090	3.8e-56	255	515
PTKc_Ror2	cd05091	3e-46	255	515
PTKc_TrkA	cd05092	1.1e-57	255	514
PTKc_TrkB	cd05093	1.9e-56	255	524
PTKc_TrkC	cd05094	6.2e-41	255	524
PTKc_DDR2	cd05095	5.7e-64	255	514
PTKc_DDR1	cd05096	3.5e-50	255	514
PTKc_DDR_like	cd05097	4.6e-61	255	514
PKc_MAPKK_Byr1_like	cd06620	5e-05	255	530
STKc_MAP4K4_6	cd06636	0.00012	255	513
STKc_STK25-YSK1	cd06642	2.9e-09	255	533
STKc_MAP4K3	cd06645	3e-07	255	512
STKc_MAP4K5	cd06646	2.9e-06	255	511
PKc_MEK2	cd06649	2.5e-05	255	549
PKc_MEK1	cd06650	0.00014	255	574
STKc_TNIK	cd06637	2.4e-06	255	513
STKc_PCTAIRE2	cd07872	1.1e-06	255	550
STKc_Nek8	cd08220	1.2e-05	255	513
PTKc_EphR	cd05033	4.8e-89	256	516
PTKc_Jak_rpt2	cd05038	7.5e-72	256	516
PTK_Ryk	cd05043	9.1e-39	256	515
PTKc_Tec_like	cd05059	1.5e-111	256	513
PTKc_EphR_A	cd05066	1.7e-70	256	516
PTKc_EphR_B	cd05065	1e-70	256	516
PTKc_Jak1_rpt2	cd05079	3.4e-47	256	516
PTKc_Tyk2_rpt2	cd05080	5.6e-36	256	517
PTKc_Jak2_Jak3_rpt2	cd05081	2.6e-52	256	516
PTKc_Tie2	cd05088	1.3e-55	256	536
PTKc_EGFR	cd05108	6.1e-59	256	570
PTKc_HER4	cd05110	5e-51	256	546
PTK_HER3	cd05111	4.6e-45	256	526
PTKc_Itk	cd05112	2.5e-93	256	513
PTKc_Btk_Bmx	cd05113	4.6e-101	256	513
PTKc_Tec_Rlk	cd05114	4.8e-95	256	513
PTKc_HER2	cd05109	4.8e-61	256	526
PKc_MKK4	cd06616	3e-10	256	529
STKc_CDK10	cd07845	8.4e-07	256	527
STKc_PCTAIRE_like	cd07844	2.7e-08	256	547
STKc_PFTAIRE1	cd07869	0.00022	256	571
STKc_MAP4K3_like	cd06613	9.2e-12	257	512
STKc_PFTAIRE2	cd07870	6e-07	257	546
STKc_MEKK3_like_1	cd06653	7.6e-06	258	514
STKc_Nek6_Nek7	cd08224	2.2e-10	258	517
STKc_phototropin_lik	cd05574	2.1e-05	259	523
STKc_PKA	cd05580	8.3e-08	259	566
STKc_PDK1	cd05581	8.6e-12	259	512
STKc_CRIK	cd05601	0.00014	259	548
STKc_MAST	cd05609	5e-05	259	579
STKc_PRKX_like	cd05612	3.7e-07	259	542
STKc_myosinIII_like	cd06608	5e-07	259	513
PKc_MAPKK	cd06605	3.7e-12	259	518
STKc_MST3_like	cd06609	4e-12	259	532
STKc_OSR1_SPAK	cd06610	1.5e-11	259	512
STKc_MST1_2	cd06612	1.3e-10	259	508
PKc_MEK	cd06615	6.5e-08	259	529
PKc_MKK3_6	cd06617	9e-11	259	530
PKc_MAPKK_Pek1_like	cd06621	3e-07	259	495
PKc_MAPKK_PBS2_like	cd06622	2.6e-08	259	573
PKc_MKK5	cd06619	1.2e-05	259	533
PKc_MAPKK_plant_like	cd06623	5.6e-13	259	518
STKc_MEKK3_like	cd06625	5.6e-10	259	514
STKc_CDKL1_4	cd07847	3.4e-09	259	547
STKc_MAPK4_6	cd07854	0.00031	259	580
STKc_CDK6	cd07862	7.3e-05	259	558
STKc_Nek7	cd08229	6.4e-12	259	517
STKc_Nek6	cd08228	8.2e-15	259	517
SPS1	COG0515	9e-35	259	676
PTKc_RET	cd05045	3.3e-67	260	519
PKc_STE	cd05122	5.8e-15	260	512
STKc_MSK_N	cd05583	5.1e-06	260	536
STKc_cPKC	cd05587	5.4e-07	260	585
STKc_MSK1_N	cd05613	0.00035	260	531
STKc_MSK2_N	cd05614	0.00023	260	589
STKc_cPKC_beta	cd05616	2.1e-05	260	573
STKc_cPKC_alpha	cd05615	2.8e-06	260	573
STKc_MAPKKK	cd06606	8.6e-20	260	506
STKc_Cdc7_like	cd06627	2.2e-15	260	512
STKc_MEKK3	cd06651	3.1e-06	260	515
STKc_CCRK	cd07832	1e-08	260	506
STKc_MAPK	cd07834	1.1e-08	260	541
STKc_Pho85	cd07836	1.8e-06	260	563
STKc_CdkB_plant	cd07837	5.3e-07	260	518
STKc_Sty1_Hog1	cd07856	6.3e-05	260	533
STKc_MPK1	cd07857	5.2e-05	260	529
STKc_TDY_MAPK_plant	cd07859	2.6e-05	260	585
STKc_CDK2_3	cd07860	1.1e-06	260	512
STKc_CDK1_euk	cd07861	1.5e-10	260	563
STKc_CDK4	cd07863	0.00015	260	512
STKc_Nek	cd08215	1.4e-15	260	521
STKc_Nek2	cd08217	2.8e-10	260	514
STKc_Nek1	cd08218	1.6e-06	260	514
STKc_Nek11	cd08222	3.4e-13	260	514
STKc_Nek4	cd08223	4.7e-09	260	513
STKc_Nek5	cd08225	2.6e-06	260	513
STKc_Nek3	cd08219	1.3e-10	260	514
STKc_Nek10	cd08528	1.2e-07	260	514
STKc_FA2-like	cd08529	1.8e-09	260	521
STKc_CNK2-like	cd08530	1.6e-07	260	512
PTKc_Axl_like	cd05035	5.8e-84	261	516
PTKc_Tyro3	cd05074	1.6e-76	261	516
PTKc_Axl	cd05075	7.1e-71	261	516
STKc_PKN	cd05589	1.2e-07	261	584
STKc_CDK1_like	cd07835	1.1e-07	261	563
STKc_GRK4_like	cd05605	6.9e-06	262	550
STKc_NAK1_like	cd06917	1.9e-11	262	529
STKc_MAK_like	cd07830	5.5e-13	262	514
STKc_CDK7	cd07841	1.3e-09	262	525
STKc_CDK_like	cd07829	9.3e-14	262	512
PK_STRAD	cd08216	3.8e-05	262	531
STKc_MAPKKK_Byr2_lik	cd06628	1.3e-11	263	513
STKc_MAPKKK_Bck1_lik	cd06629	6.4e-09	263	506
STKc_YSK4	cd06631	1.1e-09	263	512
STKc_CDKL2_3	cd07846	4.7e-09	263	512
STKc_RSK_N	cd05582	1.5e-06	264	580
STKc_p70S6K	cd05584	1.4e-05	264	580
STKc_MEKK4	cd06626	3.4e-10	264	513
STKc_CDK9_like	cd07840	5e-10	264	505
PTKc	cd00192	2e-144	265	513
PTK_Jak_rpt1	cd05037	1.9e-12	265	513
PTKc_Fes_like	cd05041	8.5e-98	265	514
PTKc_Aatyk	cd05042	1.5e-19	265	514
PTKc_c-ros	cd05044	1.1e-71	265	514
PTKc_Tie	cd05047	2.1e-64	265	517
PTKc_Syk_like	cd05060	1.1e-96	265	517
PTKc_Met_Ron	cd05058	1.6e-70	265	518
PTKc_Ack_like	cd05040	1.3e-83	265	514
PTK_Jak1_rpt1	cd05077	7.6e-11	265	513
PTK_Jak2_Jak3_rpt1	cd05078	2.2e-12	265	513
PTKc_Fes	cd05084	4.7e-79	265	514
PTKc_Fer	cd05085	7.6e-89	265	514
PTKc_Aatyk2	cd05086	2.8e-22	265	514
PTKc_Aatyk1_Aatyk3	cd05087	3.2e-35	265	514
STKc_CMGC	cd05118	6.3e-12	265	512
PTKc_Syk	cd05116	1.2e-71	265	517
STKc_PKC	cd05570	1e-09	265	569
STKc_SGK	cd05575	8.3e-06	265	566
STKc_aPKC	cd05588	6.8e-07	265	585
STKc_nPKC_epsilon	cd05591	2e-06	265	585
STKc_nPKC_theta_delt	cd05592	8.1e-08	265	580
STKc_PKB_gamma	cd05593	8.7e-06	265	595
STKc_PKB_alpha	cd05594	1.6e-07	265	581
STKc_PKB	cd05571	1.7e-08	265	586
STKc_nPKC_eta	cd05590	6.4e-06	265	567
STKc_SGK1	cd05602	0.00032	265	580
STKc_SGK2	cd05603	2.3e-07	265	581
STKc_SGK3	cd05604	0.00087	265	580
STKc_PKB_beta	cd05595	9.1e-06	265	586
STKc_aPKC_zeta	cd05617	2e-05	265	585
STKc_aPKC_iota	cd05618	8.7e-05	265	581
STKc_nPKC_theta	cd05619	4.7e-08	265	571
STKc_nPKC_delta	cd05620	0.00023	265	580
STKc_MEKK1	cd06630	1.6e-08	265	513
STKc_MOK	cd07831	7.9e-07	265	512
STKc_CDKL	cd07833	4.4e-09	265	512
PTKc_Zap-70	cd05115	4.6e-66	266	517
STKc_CDK4_6_like	cd07838	2.8e-06	266	512
STKc_CDC2L6	cd07867	0.00044	266	563
STKc_CDK8_like	cd07842	6.4e-06	266	512
PKc	cd00180	2.2e-68	267	512
STKc_AGC	cd05123	1e-11	267	512
STKc_cGK_PKG	cd05572	2.2e-09	267	519
STKc_ROCK_NDR_like	cd05573	0.00014	267	555
STKc_MAST_like	cd05579	2.2e-07	267	510
STKc_Sck1_like	cd05586	1.3e-05	267	631
STKc_GRK1	cd05608	0.00025	267	549
STKc_YPK1_like	cd05585	2.7e-06	267	579
STKc_GRK7	cd05607	0.00048	267	537
STKc_MEKK1_plant	cd06632	3.3e-11	267	508
STKc_Nek9	cd08221	2.3e-08	267	514
STKc_Yank1	cd05578	3.1e-08	268	515
STKc_CDC2L1	cd07843	0.0001	270	512
SH3_1	pfam00018	5.1e-16	86	132
SH2	pfam00017	6.8e-34	146	221
Pkinase	pfam00069	2.3e-47	261	512
SH3	smart00326	4.8e-17	81	138
SH3_2	pfam07653	1.1e-06	84	137
SH2	smart00252	1.6e-32	144	227
Pkinase_Tyr	pfam07714	2.7e-155	261	512
TyrKc	smart00219	5.3e-149	261	512
STYKc	smart00221	2e-66	261	514
S_TKc	smart00220	6e-62	271	516
KIND	smart00750	4.1e-05	340	522
F_actin_bind	pfam08919	1.3e-140	972	1149
FABD	smart00808	6.5e-70	1025	1149

Table of Mutations found on the Protein

Source ↕	Mut_ID ↕	Class ↕	HGVS ↕	Disease ↕
dbSNP	rs2229067	Polymorphism	p.SER991LEU	N/A
OMIM	189980.0003	Disease	p.GLU255LYS	LEUKEMIA, PHILADELPHIA CHROMOSOME-POSITIVE, RESISTANT TO IMATINIB
OMIM	189980.0002	Disease	p.GLU255VAL	LEUKEMIA, PHILADELPHIA CHROMOSOME-POSITIVE, RESISTANT TO IMATINIB
OMIM	189980.0006	Disease	p.MET351THR	CHRONIC MYELOID LEUKEMIA, RESISTANT TO IMATINIB
OMIM	189980.0005	Disease	p.PHE311LEU	CHRONIC MYELOID LEUKEMIA, RESISTANT TO IMATINIB
OMIM	189980.0001	Disease	p.THR315ILE	LEUKEMIA, PHILADELPHIA CHROMOSOME-POSITIVE, RESISTANT TO IMATINIB
OMIM	189980.0004	Disease	p.TYR253HIS	LEUKEMIA, PHILADELPHIA CHROMOSOME-POSITIVE, RESISTANT TO IMATINIB

Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

DMDM_info@umbc.edu | 1000 Hilltop Circle, Baltimore, MD 21250 | Department of Biological Sciences | Phone: 410-455-2258