Results for the protein: Q5VT25

Results for the Protein: Q5VT25

74746874

8476

CDC42BPA

NCBI, UniProt

MRCKA_HUMAN RecName: Full=Serine/threonine-protein kinase MRCK alpha; AltName: Full=CDC42-binding protein kinase alpha; AltName: Full=DMPK-like alpha; AltName: Full=Myotonic dystrophy kinase-related CDC42-binding kinase alpha; Short=MRCK alpha; Short=Myotonic dystrophy protein kinase-like alpha

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Swiss-Prot Protein: Q5VT25

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Domains found on the Protein

Domain ↕	CD Accession ↕	E-Value ↕	Start ↕	End ↕
STKc_ROCK2	cd05621	2.4e-143	33	406
STKc_ROCK1	cd05622	2e-148	33	407
STKc_JNK1	cd07875	0.00077	45	419
STKc_PAK2	cd06655	9.1e-08	50	370
STKc_PAK_I	cd06647	1.1e-07	50	367
STKc_myosinIIIB	cd06639	1.4e-08	54	344
STKc_PAK1	cd06654	7.2e-08	55	372
STKc_PAK3	cd06656	4.9e-09	55	364
STKc_CDK9	cd07865	1.1e-06	55	343
STKc_PAK_II	cd06648	3.4e-10	58	359
STKc_PAK4	cd06657	6.1e-07	58	365
STKc_PAK5	cd06658	9.2e-07	58	363
STKc_PAK6	cd06659	6.1e-10	58	369
STKc_JNK	cd07850	5.1e-05	58	384
STKc_p38alpha_MAPK14	cd07877	0.00074	60	401
STKc_TAO2	cd06634	0.00021	61	388
STKc_MAP4K4_6	cd06636	4.3e-06	61	343
STKc_JNK2	cd07876	0.00083	61	417
STKc_PAK	cd06614	8.7e-14	62	359
STKc_TAO1	cd06635	8.9e-05	62	387
STKc_myosinIIIA	cd06638	6.4e-09	62	343
PKc_MKK7	cd06618	9.9e-10	63	364
STKc_p38	cd07851	6.1e-07	63	386
STKc_p38gamma_MAPK12	cd07880	3.5e-06	63	401
STKc_p38beta_MAPK11	cd07878	0.00012	63	401
STKc_STK10_LOK	cd06644	9.8e-09	65	362
STKc_TAO	cd06607	3.4e-05	66	386
STKc_ASK	cd06624	2e-08	68	343
STKc_MAP4K5	cd06646	1.1e-06	69	342
STKc_MAP4K3	cd06645	4.7e-08	69	342
PTKc_ALK_LTK	cd05036	3.4e-05	70	316
PTKc_FAK	cd05056	1.1e-06	70	333
PTKc_Frk_like	cd05068	1.5e-05	70	337
PTKc_Yes	cd05069	4.5e-05	70	337
PTKc_Lck_Blk	cd05067	0.00069	70	350
PTKc_Fyn_Yrk	cd05070	0.0001	70	337
PTKc_Src	cd05071	0.00015	70	343
PTKc_Abl	cd05052	2.9e-06	70	338
PTKc_Hck	cd05073	9.9e-06	70	337
PTKc_Lyn	cd05072	9.1e-06	70	337
PTKc_EGFR	cd05108	0.00046	70	360
STKc_TNIK	cd06637	3.7e-07	70	343
STKc_ERK5	cd07855	1.1e-06	70	381
STKc_TEY_MAPK_plant	cd07858	2.2e-06	70	386
STKc_CDK12	cd07864	4.7e-08	70	334
PTKc_Trk	cd05049	4.7e-06	71	323
PTKc_Musk	cd05050	2.9e-05	71	331
PTKc_EphR_A2	cd05063	0.00022	71	342
PTKc_EphR_A10	cd05064	3.1e-05	71	334
PTKc_TrkB	cd05093	0.0006	71	345
PTKc_DDR2	cd05095	0.00065	71	352
PTKc_TrkA	cd05092	7.1e-05	71	344
PKc_MEK2	cd06649	9.5e-07	71	423
PKc_MEK1	cd06650	1.7e-05	71	421
PTKc_InsR_like	cd05032	3e-05	72	323
PTKc_EphR	cd05033	0.00019	72	318
PTKc_Src_like	cd05034	2.1e-05	72	337
PTKc_Jak_rpt2	cd05038	5.4e-06	72	327
PTKc_Tec_like	cd05059	1.4e-05	72	322
PTKc_EphR_A	cd05066	0.00013	72	342
PTKc_Tyk2_rpt2	cd05080	0.00092	72	326
PTKc_Tie2	cd05088	0.00016	72	348
PTKc_EphR_B	cd05065	0.00036	72	342
PTKc_Itk	cd05112	1.3e-05	72	330
PTKc_Btk_Bmx	cd05113	4.9e-07	72	347
PTKc_Tec_Rlk	cd05114	2.8e-07	72	342
PTK_HER3	cd05111	0.00039	72	347
PTKc_Srm_Brk	cd05148	2.5e-05	72	313
PKc_MKK4	cd06616	1.8e-08	72	363
PKc_MAPKK_Byr1_like	cd06620	7.1e-10	72	414
STKc_SLK	cd06643	3.1e-10	72	358
STKc_MAP4K3_like	cd06613	2.1e-12	73	342
STKc_PCTAIRE_like	cd07844	4.5e-07	73	362
STKc_PFTAIRE1	cd07869	0.00021	73	352
STKc_PFTAIRE2	cd07870	5.2e-05	73	359
STKc_PCTAIRE3	cd07871	4.7e-06	73	343
STKc_PCTAIRE2	cd07872	1.6e-05	73	379
STKc_BUR1	cd07866	1.3e-07	73	343
STKc_PCTAIRE1	cd07873	1.3e-05	73	355
STKc_SLK_like	cd06611	7.5e-10	74	324
STKc_MST4	cd06640	2.8e-08	74	355
STKc_MST3	cd06641	7.5e-08	74	344
STKc_STK25-YSK1	cd06642	2.3e-08	74	355
STKc_MEKK2	cd06652	9.8e-07	74	344
STKc_MEKK3_like_1	cd06653	1.2e-08	74	343
STKc_ERK1_2_like	cd07849	1.4e-05	74	385
STKc_Nek6_Nek7	cd08224	5.7e-10	74	343
PTKc_Tie1	cd05089	0.00021	75	347
STKc_phototropin_lik	cd05574	7.5e-59	75	367
STKc_ROCK_NDR_like	cd05573	2.2e-193	75	405
STKc_PDK1	cd05581	8.1e-63	75	343
STKc_DMPK_like	cd05597	1.1e-255	75	405
STKc_PKA	cd05580	8.7e-76	75	374
STKc_LATS	cd05598	1.5e-98	75	408
STKc_NDR_like	cd05599	1.1e-120	75	408
STKc_CRIK	cd05601	1.5e-153	75	405
STKc_MAST	cd05609	4.6e-63	75	372
STKc_MRCK_alpha	cd05623		75	406
STKc_MRCK_beta	cd05624	6.3e-280	75	405
STKc_LATS2	cd05626	3.9e-80	75	410
STKc_NDR2	cd05627	6.7e-95	75	429
STKc_NDR_like_fungal	cd05629	1.4e-103	75	408
STKc_NDR1	cd05628	4e-102	75	408
STKc_MASTL	cd05610	5.8e-05	75	733
STKc_Sid2p_Dbf2p	cd05600	8.4e-67	75	406
STKc_PRKX_like	cd05612	1.7e-69	75	375
PKc_MAPKK	cd06605	8.9e-11	75	348
STKc_myosinIII_like	cd06608	2.7e-11	75	343
STKc_MST3_like	cd06609	1.1e-11	75	341
STKc_OSR1_SPAK	cd06610	1.5e-13	75	343
STKc_MST1_2	cd06612	3.3e-13	75	343
PKc_MEK	cd06615	2.7e-11	75	410
PKc_MKK3_6	cd06617	3.1e-08	75	360
PKc_MAPKK_Pek1_like	cd06621	4e-08	75	342
PKc_MAPKK_PBS2_like	cd06622	1.8e-07	75	381
PKc_MAPKK_plant_like	cd06623	1.2e-15	75	335
PKc_MKK5	cd06619	0.00022	75	366
STKc_NAK1_like	cd06917	1.3e-10	75	322
STKc_CDKL	cd07833	3.1e-09	75	343
STKc_CdkB_plant	cd07837	2.1e-08	75	344
STKc_CDK10	cd07845	1.9e-06	75	365
STKc_CDKL2_3	cd07846	5.1e-09	75	343
STKc_CDKL1_4	cd07847	1.8e-10	75	359
STKc_CDK6	cd07862	6.1e-05	75	343
STKc_CDC2L1	cd07843	7.1e-08	75	343
STKc_CDKL5	cd07848	6.5e-07	75	343
STKc_Nek6	cd08228	1.5e-10	75	343
STKc_Nek7	cd08229	3.8e-11	75	343
SPS1	COG0515	4.8e-52	75	494
PKc_STE	cd05122	4.3e-27	76	342
STKc_MSK_N	cd05583	9.9e-69	76	360
STKc_cPKC	cd05587	4.3e-59	76	406
STKc_GRK4_like	cd05605	1.5e-36	76	362
STKc_MSK1_N	cd05613	1.1e-51	76	360
STKc_MSK2_N	cd05614	3.8e-61	76	407
STKc_cPKC_alpha	cd05615	3.3e-45	76	406
STKc_cPKC_beta	cd05616	5.8e-51	76	406
STKc_GRK6	cd05630	5.2e-31	76	362
STKc_GRK4	cd05631	3.2e-32	76	362
STKc_GRK5	cd05632	2.6e-30	76	362
STKc_Yank1	cd05578	8.2e-66	76	343
STKc_Cdc7_like	cd06627	2.3e-14	76	343
STKc_MAPKKK	cd06606	1.8e-34	76	343
STKc_MEKK3	cd06651	2e-10	76	345
STKc_CCRK	cd07832	2.5e-13	76	344
STKc_Pho85	cd07836	0.0001	76	359
STKc_CDK5	cd07839	6.6e-07	76	343
STKc_CDK8_like	cd07842	4.4e-05	76	343
STKc_CDK7	cd07841	3.3e-08	76	330
STKc_CDK2_3	cd07860	7.7e-06	76	343
STKc_CDK1_euk	cd07861	8.1e-07	76	359
STKc_CDK4	cd07863	3.5e-05	76	359
STKc_TDY_MAPK_plant	cd07859	4e-07	76	396
STKc_NLK	cd07853	1.4e-05	76	490
STKc_MAPK	cd07834	1e-06	76	381
STKc_MPK1	cd07857	3.3e-06	76	362
STKc_Nek2	cd08217	5.5e-17	76	334
STKc_Nek3	cd08219	4.2e-23	76	334
STKc_Nek8	cd08220	1.3e-11	76	343
STKc_Nek9	cd08221	9.1e-09	76	323
STKc_Nek1	cd08218	3.7e-22	76	343
STKc_Nek4	cd08223	4.6e-16	76	343
STKc_Nek11	cd08222	2e-07	76	343
STKc_Nek	cd08215	2.9e-20	76	328
STKc_Nek5	cd08225	1.5e-20	76	343
STKc_Nek10	cd08528	9.3e-08	76	336
STKc_FA2-like	cd08529	2.4e-14	76	334
STKc_CNK2-like	cd08530	9.6e-12	76	343
PTKc_Jak2_Jak3_rpt2	cd05081	2.5e-05	77	352
STKc_CMGC	cd05118	2.1e-13	77	343
STKc_PKN	cd05589	3.8e-58	77	405
STKc_LATS1	cd05625	2.5e-71	77	408
STKc_MAPKKK_Bck1_lik	cd06629	1.3e-06	77	343
STKc_CDK_like	cd07829	4.7e-13	77	343
STKc_MAK_like	cd07830	4e-09	77	343
STKc_MOK	cd07831	9.4e-10	77	343
STKc_CDK4_6_like	cd07838	7.4e-09	77	343
STKc_CDK9_like	cd07840	3.6e-10	77	343
STKc_MAPK15	cd07852	8.8e-06	77	346
STKc_CDK1_like	cd07835	3.4e-07	77	343
STKc_Sty1_Hog1	cd07856	4e-05	77	387
STKc_MAPKKK_Byr2_lik	cd06628	2.5e-08	78	343
PK_STRAD	cd08216	1.7e-05	78	320
PK_STRAD_alpha	cd08227	6.4e-05	78	416
STKc_RSK_N	cd05582	8.4e-65	80	405
STKc_p70S6K	cd05584	8.1e-69	80	407
STKc_Rim15_like	cd05611	5e-22	80	349
STKc_MEKK4	cd06626	3.1e-13	80	343
PTKc	cd00192	1.2e-08	81	322
PTKc_Ack_like	cd05040	7.8e-05	81	312
PTKc_Fes_like	cd05041	4.8e-09	81	312
PTKc_c-ros	cd05044	3.7e-05	81	331
PTKc_Tie	cd05047	0.00064	81	355
PTKc_Syk_like	cd05060	3.2e-05	81	356
PTKc_Fes	cd05084	5e-06	81	352
PTKc_Fer	cd05085	1.7e-05	81	319
PTKc_Syk	cd05116	3.5e-05	81	343
STKc_PKC	cd05570	1.5e-48	81	405
STKc_SGK	cd05575	6.1e-72	81	405
STKc_aPKC	cd05588	1.1e-48	81	406
STKc_nPKC_epsilon	cd05591	6.8e-59	81	406
STKc_nPKC_theta_delt	cd05592	2.6e-61	81	407
STKc_PKB_gamma	cd05593	5e-46	81	410
STKc_PKB_alpha	cd05594	1.7e-47	81	408
STKc_PKB_beta	cd05595	6.3e-53	81	407
STKc_nPKC_eta	cd05590	3.8e-62	81	406
STKc_PKB	cd05571	5.6e-64	81	407
STKc_SGK2	cd05603	5e-60	81	406
STKc_SGK3	cd05604	5.6e-56	81	407
STKc_aPKC_zeta	cd05617	1.5e-37	81	406
STKc_aPKC_iota	cd05618	4.1e-35	81	406
STKc_nPKC_theta	cd05619	1e-49	81	407
STKc_nPKC_delta	cd05620	1.9e-42	81	407
STKc_SGK1	cd05602	2.9e-55	81	407
STKc_MEKK1	cd06630	3.5e-08	81	344
STKc_YSK4	cd06631	2e-09	81	343
STKc_MEKK1_plant	cd06632	5.6e-11	81	343
STKc_MEKK3_like	cd06625	5.8e-14	81	343
STKc_beta_ARK	cd05606	3.1e-34	82	361
STKc_GRK3	cd05633	3e-25	82	362
PKc	cd00180	6.4e-61	83	341
PTKc_Zap-70	cd05115	5.7e-06	83	343
STKc_AGC	cd05123	4.9e-108	83	343
STKc_cGK_PKG	cd05572	1.4e-55	83	350
STKc_GRK	cd05577	1.5e-30	83	361
STKc_MAST_like	cd05579	1.4e-75	83	348
STKc_YPK1_like	cd05585	1e-66	83	404
STKc_Sck1_like	cd05586	1.1e-57	83	444
STKc_GRK7	cd05607	3.4e-33	83	361
STKc_GRK1	cd05608	1.2e-34	83	361
C1	cd00029	1e-12	1013	1062
PH_MRCK	cd01243	2.8e-104	1082	1203
PH	cd00821	3.4e-09	1085	1199
PH-like	cd00900	2.6e-10	1085	1199
CRIB	cd00132	4.5e-11	1569	1607
Pkinase	pfam00069	4.1e-59	77	343
Pkinase_C	pfam00433	2.8e-14	361	408
C1_1	pfam00130	3.6e-13	1013	1065
PH	pfam00169	0.0005	1083	1201
CNH	pfam00780	1.1e-96	1232	1496
Pkinase_Tyr	pfam07714	8.4e-13	77	321
TyrKc	smart00219	2e-11	77	321
STYKc	smart00221	5.9e-79	77	343
S_TKc	smart00220	1.8e-87	87	343
S_TK_X	smart00133	6.1e-17	344	406
DMPK_coil	pfam08826	4.1e-32	881	941
C1	smart00109	1.6e-09	1013	1062
PH	smart00233	1.5e-08	1083	1201
CNH	smart00036	4e-14	1228	1510
PBD	smart00285	1.4e-11	1571	1606

Table of Mutations found on the Protein

Source ↕	Mut_ID ↕	Class ↕	HGVS ↕	Disease ↕
Swiss-Prot	VAR_045585	Polymorphism	p.ALA1148THR	N/A
Swiss-Prot	VAR_045588	Polymorphism	p.ALA1469VAL	N/A
Swiss-Prot	VAR_045590	Polymorphism	p.ALA1699VAL	N/A
Swiss-Prot	VAR_057104	Polymorphism	p.ALA1712VAL	N/A
Swiss-Prot	VAR_045586	Polymorphism	p.ARG1211HIS	N/A
Swiss-Prot	VAR_040830	Polymorphism	p.GLU50LYS	N/A
Swiss-Prot	VAR_040833	Polymorphism	p.ILE1418LYS	N/A
Swiss-Prot	VAR_040832	Polymorphism	p.ILE537THR	N/A
Swiss-Prot	VAR_045589	Polymorphism	p.THR1618ALA	N/A
Swiss-Prot	VAR_040831	Polymorphism	p.THR231MET	N/A
Swiss-Prot	VAR_045583	Polymorphism	p.THR780MET	N/A
Swiss-Prot	VAR_045584	Polymorphism	p.TYR790CYS	N/A
Swiss-Prot	VAR_045587	Polymorphism	p.VAL1317ILE	N/A

Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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