Results for the protein: Q9UHD2

Results for the Protein: Q9UHD2

74761953

29110

TBK1

NCBI, UniProt

TBK1_HUMAN RecName: Full=Serine/threonine-protein kinase TBK1; AltName: Full=NF-kappa-B-activating kinase; AltName: Full=T2K; AltName: Full=TANK-binding kinase 1

			0 9 0 0 9

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Swiss-Prot Protein: Q9UHD2

Identical to: NP_037386

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Domains found on the Protein

Domain ↕	CD Accession ↕	E-Value ↕	Start ↕	End ↕
PTKc_InsR	cd05061	0.00048	1	298
PTKc_Tie2	cd05088	0.00024	1	297
STKc_myosinIIIA	cd06638	2.3e-05	1	290
STKc_myosinIIIB	cd06639	3.3e-05	1	291
STKc_STK10_LOK	cd06644	3.6e-07	1	306
STKc_MAP4K3	cd06645	5.9e-06	1	295
STKc_MAP4K5	cd06646	3.9e-05	1	295
STKc_PAK6	cd06659	0.0004	1	305
STKc_CDK10	cd07845	2e-05	1	315
STKc_JNK	cd07850	0.00094	1	357
STKc_BUR1	cd07866	2.2e-06	1	299
STKc_PFTAIRE2	cd07870	3.6e-06	1	330
STKc_p38gamma_MAPK12	cd07880	2.8e-05	1	351
PTKc_ALK_LTK	cd05036	1.1e-06	2	259
PTKc_Musk	cd05050	0.00044	2	275
PTKc_FAK	cd05056	6.3e-05	2	289
STKc_TAO	cd06607	0.0003	2	327
STKc_PAK	cd06614	3.1e-09	2	238
PKc_MKK7	cd06618	6.4e-07	2	305
STKc_TAO2	cd06634	0.00046	2	309
STKc_MAP4K4_6	cd06636	6.3e-05	2	281
STKc_TNIK	cd06637	6.3e-06	2	281
PKc_MEK2	cd06649	0.00025	2	352
PKc_MEK1	cd06650	0.00024	2	347
STKc_PAK2	cd06655	9.6e-05	2	292
STKc_p38	cd07851	0.00016	2	329
STKc_CDK12	cd07864	3e-06	2	306
PTKc_Jak_rpt2	cd05038	4.2e-07	3	310
PTKc_Trk	cd05049	1.4e-05	3	287
PTKc_IGF-1R	cd05062	0.00011	3	286
PTKc_Frk_like	cd05068	5e-06	3	276
PTKc_Yes	cd05069	0.00018	3	280
PTKc_Fyn_Yrk	cd05070	0.00063	3	288
PTKc_Src	cd05071	0.00029	3	282
PTKc_Hck	cd05073	0.00085	3	288
STKc_PAK_I	cd06647	0.0001	3	300
STKc_SLK	cd06643	2.3e-07	3	289
STKc_PAK1	cd06654	5.6e-05	3	291
STKc_TEY_MAPK_plant	cd07858	1.7e-05	3	348
PTKc_InsR_like	cd05032	4.2e-05	4	286
PTKc_EphR	cd05033	0.00018	4	277
PTKc_Jak1_rpt2	cd05079	0.00013	4	306
PTKc_Jak2_Jak3_rpt2	cd05081	4.1e-05	4	289
PTKc_Itk	cd05112	1.1e-06	4	277
PTKc_Btk_Bmx	cd05113	2.3e-07	4	274
PTKc_Tec_Rlk	cd05114	2.9e-05	4	274
PKc_MKK4	cd06616	3.8e-06	4	306
PKc_MAPKK_Byr1_like	cd06620	4.6e-06	4	294
STKc_MST4	cd06640	0.00032	4	294
STKc_MST3	cd06641	0.00023	4	294
STKc_STK25-YSK1	cd06642	0.00015	4	294
STKc_PAK3	cd06656	0.00015	4	293
STKc_PCTAIRE_like	cd07844	7.5e-07	4	310
STKc_CDK9	cd07865	2.1e-06	4	260
PTKc_Csk_like	cd05039	0.00059	5	207
STKc_MST1_2	cd06612	1.9e-12	5	257
STKc_MAP4K3_like	cd06613	6.6e-10	5	251
STKc_ASK	cd06624	2.4e-08	5	281
STKc_phototropin_lik	cd05574	2.3e-08	6	286
STKc_myosinIII_like	cd06608	1.7e-09	6	281
STKc_SLK_like	cd06611	4.5e-07	6	279
PKc_MEK	cd06615	6.9e-07	6	343
PKc_MKK3_6	cd06617	0.00015	6	286
PKc_MAPKK_Pek1_like	cd06621	2.3e-08	6	293
PKc_MAPKK_PBS2_like	cd06622	2.1e-05	6	276
PKc_MAPKK_plant_like	cd06623	8e-12	6	286
STKc_PAK_II	cd06648	7.7e-05	6	285
STKc_MEKK3_like_1	cd06653	6.2e-07	6	275
STKc_CDKL1_4	cd07847	8.6e-08	6	325
STKc_CDKL5	cd07848	7.2e-05	6	310
STKc_ERK1_2_like	cd07849	0.00035	6	359
PK_STRAD	cd08216	0.00031	6	283
PTKc_Ror	cd05048	6.4e-05	7	276
PTKc_Tyk2_rpt2	cd05080	1e-05	7	293
STKc_ROCK_NDR_like	cd05573	3.3e-05	7	301
STKc_DMPK_like	cd05597	2e-06	7	360
STKc_MAST	cd05609	1.4e-06	7	337
STKc_PRKX_like	cd05612	8.9e-08	7	296
STKc_MRCK_beta	cd05624	9.2e-05	7	327
STKc_MST3_like	cd06609	9.7e-09	7	294
STKc_MAPKKK_Bck1_lik	cd06629	8e-06	7	275
STKc_NAK1_like	cd06917	3.4e-08	7	289
STKc_MAPK	cd07834	4.2e-06	7	327
STKc_CDK6	cd07862	0.00049	7	310
STKc_PCTAIRE3	cd07871	6.2e-06	7	304
STKc_PCTAIRE2	cd07872	7.4e-06	7	317
STKc_PCTAIRE1	cd07873	3.9e-05	7	311
STKc_Nek6_Nek7	cd08224	2.7e-05	7	308
SPS1	COG0515	2.4e-35	7	469
PTKc_HER4	cd05110	0.00076	8	343
PKc_STE	cd05122	2.2e-14	8	252
STKc_GRK4_like	cd05605	5e-06	8	311
STKc_GRK5	cd05632	0.00014	8	302
STKc_GRK4	cd05631	0.00041	8	297
STKc_MEKK4	cd06626	4.2e-12	8	246
STKc_MAPKKK_Byr2_lik	cd06628	2e-07	8	281
STKc_MEKK1	cd06630	6.1e-08	8	267
STKc_YSK4	cd06631	2e-10	8	281
STKc_MEKK1_plant	cd06632	2.1e-09	8	281
STKc_MAPKKK	cd06606	2.2e-19	8	281
STKc_Cdc7_like	cd06627	1.3e-13	8	260
STKc_CCRK	cd07832	1.1e-09	8	300
STKc_Pho85	cd07836	2.3e-06	8	304
STKc_CDK7	cd07841	3.8e-08	8	264
STKc_MPK1	cd07857	0.00021	8	313
STKc_TDY_MAPK_plant	cd07859	3.5e-06	8	337
STKc_Nek4	cd08223	9.8e-06	8	257
STKc_Nek5	cd08225	1.7e-05	8	281
STKc_Nek10	cd08528	9.3e-06	8	265
PTKc_Src_like	cd05034	3.2e-06	9	259
PTKc_Abl	cd05052	8.7e-06	9	277
PTKc_Srm_Brk	cd05148	4.8e-07	9	257
STKc_Yank1	cd05578	1.6e-10	9	296
STKc_MSK_N	cd05583	1.5e-07	9	316
STKc_cPKC	cd05587	0.0003	9	329
STKc_PKN	cd05589	2.4e-06	9	298
STKc_CRIK	cd05601	1.5e-06	9	305
STKc_MSK1_N	cd05613	7.4e-06	9	316
STKc_MSK2_N	cd05614	1.1e-06	9	362
STKc_cPKC_alpha	cd05615	0.00033	9	327
STKc_MRCK_alpha	cd05623	0.00015	9	328
STKc_MEKK3_like	cd06625	2.2e-10	9	275
STKc_MEKK3	cd06651	3.6e-09	9	284
STKc_MEKK2	cd06652	2.1e-06	9	283
STKc_CDK_like	cd07829	8.2e-11	9	287
STKc_MAK_like	cd07830	8.5e-09	9	330
STKc_MOK	cd07831	2.7e-08	9	330
STKc_CDK1_like	cd07835	0.00074	9	330
STKc_CDK4_6_like	cd07838	1.4e-07	9	299
STKc_CDK9_like	cd07840	1.2e-08	9	251
STKc_CDK1_euk	cd07861	8.4e-05	9	330
STKc_Nek1	cd08218	1.7e-05	9	290
STKc_Nek3	cd08219	1.5e-07	9	274
STKc_Nek11	cd08222	0.00025	9	257
STKc_Nek7	cd08229	2.6e-05	9	275
STKc_FA2-like	cd08529	1.5e-07	9	281
STKc_PKA	cd05580	1.3e-07	10	298
STKc_OSR1_SPAK	cd06610	5.7e-11	11	281
STKc_CDK8_like	cd07842	0.00048	11	299
STKc_CNK2-like	cd08530	4.3e-06	11	282
STKc_RSK_N	cd05582	1.5e-06	12	360
STKc_p70S6K	cd05584	3.7e-06	12	369
PKc_MAPKK	cd06605	1.7e-10	12	254
PTKc	cd00192	1.9e-07	13	274
PTKc_Ack_like	cd05040	1.2e-07	13	252
PTKc_Fes_like	cd05041	2.7e-08	13	252
PTKc_c-ros	cd05044	0.00067	13	287
PTKc_Tie	cd05047	0.00068	13	274
PTKc_Met_Ron	cd05058	0.00068	13	287
PTK_Jak2_Jak3_rpt1	cd05078	0.00098	13	274
PTKc_Fes	cd05084	2.1e-05	13	278
PTKc_Fer	cd05085	5.3e-05	13	275
PTKc_Syk	cd05116	1.1e-05	13	281
STKc_CMGC	cd05118	3.3e-11	13	281
STKc_PKC	cd05570	3.2e-09	13	298
STKc_PKB	cd05571	1.6e-07	13	357
STKc_SGK	cd05575	9e-05	13	373
STKc_PDK1	cd05581	5.1e-11	13	299
STKc_aPKC	cd05588	1.1e-05	13	361
STKc_nPKC_eta	cd05590	4.5e-05	13	328
STKc_nPKC_theta_delt	cd05592	0.00011	13	329
STKc_PKB_gamma	cd05593	2e-05	13	385
STKc_PKB_alpha	cd05594	5.6e-06	13	344
STKc_nPKC_epsilon	cd05591	3.2e-05	13	331
STKc_PKB_beta	cd05595	1.1e-05	13	343
STKc_SGK1	cd05602	0.0002	13	385
STKc_SGK2	cd05603	6.8e-06	13	342
STKc_SGK3	cd05604	0.00075	13	375
STKc_aPKC_zeta	cd05617	5.8e-05	13	342
STKc_aPKC_iota	cd05618	0.00065	13	327
STKc_nPKC_theta	cd05619	1.7e-06	13	328
STKc_NDR1	cd05628	0.00031	13	344
STKc_CdkB_plant	cd07837	2.4e-06	13	296
STKc_CDKL2_3	cd07846	3.5e-08	13	330
STKc_CDK5	cd07839	6.2e-06	13	296
STKc_Nek	cd08215	1.5e-14	13	258
STKc_Nek2	cd08217	7.3e-09	13	246
STKc_beta_ARK	cd05606	0.00026	14	326
STKc_CDKL	cd07833	3.3e-08	14	298
STKc_Nek8	cd08220	1.5e-05	14	304
STKc_Nek9	cd08221	3.8e-06	14	306
PKc	cd00180	5.3e-68	15	328
PTKc_Tec_like	cd05059	9.8e-07	15	274
PTKc_Syk_like	cd05060	0.00015	15	274
PTKc_Zap-70	cd05115	1.3e-05	15	278
STKc_AGC	cd05123	4e-14	15	325
STKc_cGK_PKG	cd05572	3.3e-09	15	261
STKc_GRK	cd05577	1.5e-06	15	283
STKc_YPK1_like	cd05585	8e-05	15	329
STKc_Sck1_like	cd05586	2.7e-05	15	375
STKc_GRK7	cd05607	2.7e-05	15	310
STKc_GRK1	cd05608	6e-08	15	301
STKc_MAST_like	cd05579	2.8e-11	15	259
STKc_NLK	cd07853	0.00049	15	357
STKc_CDK4	cd07863	3.3e-05	15	315
STKc_Rim15_like	cd05611	0.00041	17	332
STKc_CDC2L1	cd07843	9.4e-06	22	281
Pkinase	pfam00069	1.7e-37	9	281
Pkinase_Tyr	pfam07714	1.1e-09	8	277
TyrKc	smart00219	1.6e-10	9	263
STYKc	smart00221	2.5e-41	9	294
S_TKc	smart00220	1.3e-41	19	310

Table of Mutations found on the Protein

Source ↕	Mut_ID ↕	Class ↕	HGVS ↕	Disease ↕
Swiss-Prot	VAR_041208	Polymorphism	p.ARG271GLN	N/A
Swiss-Prot	VAR_024746	Polymorphism	p.ASN388ASP	N/A
Swiss-Prot	VAR_041210	Polymorphism	p.ASP296HIS	N/A
Swiss-Prot	VAR_041211	Polymorphism	p.GLY410ARG	N/A
Swiss-Prot	VAR_069755	Polymorphism	p.LEU306ILE	N/A
Swiss-Prot	VAR_024747	Polymorphism	p.LYS570GLN	N/A
Swiss-Prot	VAR_041209	Polymorphism	p.LYS291GLU	N/A
Swiss-Prot	VAR_069754	Polymorphism	p.SER151PHE	N/A
Swiss-Prot	VAR_041212	Polymorphism	p.VAL464ALA	N/A

Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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