Results for the protein: Q8NFD2

Results for the Protein: Q8NFD2

74762569

255239

ANKK1

NCBI, UniProt

ANKK1_HUMAN RecName: Full=Ankyrin repeat and protein kinase domain-containing protein 1; AltName: Full=Protein kinase PKK2; AltName: Full=Sugen kinase 288; Short=SgK288; AltName: Full=X-kinase

Known Diseases associated with this Protein:
DOPAMINE RECEPTOR D2, REDUCED BRAIN DENSITY OF

1

22

1

4

18

Tips:

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Swiss-Prot Protein: Q8NFD2

Identical to: NP_848605

Default View:

Domains found on the Protein

Domain ↕	CD Accession ↕	E-Value ↕	Start ↕	End ↕
STKc_PAK2	cd06655	1.5e-05	1	306
PTKc_EphR	cd05033	4.9e-10	3	289
STKc_PAK1	cd06654	8.4e-06	3	302
STKc_TAO	cd06607	4.2e-05	4	315
STKc_TAO2	cd06634	8.7e-06	4	316
STKc_MST4	cd06640	0.00023	4	311
STKc_PAK_I	cd06647	2.5e-05	4	303
STKc_PAK3	cd06656	7e-06	4	315
PTKc_EGFR_like	cd05057	8.8e-07	5	299
STKc_PAK	cd06614	6.7e-12	5	292
STKc_TAO1	cd06635	6.6e-06	5	315
STKc_PAK_II	cd06648	5.7e-06	6	292
PTKc_Ror	cd05048	4.9e-09	7	288
PTKc_Trk	cd05049	1.6e-08	7	293
PTKc_DDR1	cd05096	7.6e-05	7	286
PTKc_FGFR1	cd05098	8.1e-06	7	296
PTKc_FGFR2	cd05101	3.5e-06	7	296
PTKc_Ror2	cd05091	0.00032	7	288
PKc_MKK7	cd06618	7.6e-08	7	306
PTKc_FGFR4	cd05099	1.2e-07	8	304
STKc_myosinIIIA	cd06638	0.0003	9	287
STKc_CDK9	cd07865	0.00024	9	278
PTKc_FGFR3	cd05100	8.7e-05	10	323
STKc_Sty1_Hog1	cd07856	0.00011	10	332
STKc_PCTAIRE3	cd07871	0.001	10	319
STKc_CDK12	cd07864	0.00012	11	288
PTKc_Ror1	cd05090	8.7e-07	12	288
PTKc_FGFR	cd05053	1.9e-08	13	290
PTKc_Tie2	cd05088	7.2e-06	13	310
PTKc_EGFR	cd05108	1.8e-07	13	339
PTKc_HER2	cd05109	6.7e-07	13	299
PTKc_HER4	cd05110	1.1e-05	13	333
STKc_STK10_LOK	cd06644	4.6e-06	13	305
PTKc_ALK_LTK	cd05036	8.3e-11	14	285
STKc_NAK1_like	cd06917	1.8e-07	14	292
PTK_CCK4	cd05046	1.6e-06	15	287
PTKc_DDR	cd05051	1.5e-06	15	293
PTKc_FAK	cd05056	9.3e-11	15	293
PTKc_Axl	cd05075	8.1e-05	15	289
PTKc_Csk	cd05082	7.9e-07	15	288
PKc_STE	cd05122	6.9e-16	15	278
PTK_HER3	cd05111	0.0003	15	299
PTKc_InsR_like	cd05032	5e-11	16	294
PTKc_Musk	cd05050	3.5e-10	16	287
PTKc_Abl	cd05052	6.8e-13	16	289
PTKc_InsR	cd05061	5e-07	16	296
PTKc_IGF-1R	cd05062	7.4e-07	16	285
PTKc_EphR_A	cd05066	1.8e-06	16	289
PTKc_Lck_Blk	cd05067	6.9e-06	16	286
PTKc_Frk_like	cd05068	2.6e-19	16	288
PTKc_Yes	cd05069	4.1e-09	16	288
PTKc_Fyn_Yrk	cd05070	5.8e-08	16	286
PTKc_Src	cd05071	8.3e-08	16	288
PTKc_Lyn	cd05072	2.6e-09	16	288
PTKc_Hck	cd05073	2.4e-09	16	287
PTKc_Tie1	cd05089	4.9e-05	16	308
PTKc_TrkA	cd05092	1.4e-07	16	293
PTKc_TrkC	cd05094	0.00013	16	300
PTKc_DDR2	cd05095	3.4e-07	16	287
PTKc_DDR_like	cd05097	2.4e-06	16	290
PTKc_TrkB	cd05093	4.9e-06	16	301
PKc_MKK4	cd06616	2.5e-08	16	304
STKc_ASK	cd06624	7.6e-07	16	287
STKc_MAP4K3	cd06645	2.1e-05	16	283
STKc_MAP4K5	cd06646	5.6e-05	16	286
STKc_PAK6	cd06659	6.9e-05	16	310
STKc_PCTAIRE_like	cd07844	0.00027	16	309
STKc_ERK1_2_like	cd07849	0.00016	16	330
STKc_TEY_MAPK_plant	cd07858	1.8e-05	16	338
PTKc_Jak_rpt2	cd05038	1.7e-10	17	289
PTKc_Src_like	cd05034	5.3e-13	17	287
PTK_Ryk	cd05043	5.6e-06	17	287
PTKc_EphR_A2	cd05063	1.9e-07	17	289
PTKc_Itk	cd05112	1.3e-09	17	286
STKc_MAP4K3_like	cd06613	7.4e-11	17	286
STKc_TNIK	cd06637	0.00015	17	287
STKc_STK25-YSK1	cd06642	1.3e-05	17	299
PTKc_Srm_Brk	cd05148	2.2e-08	18	288
STKc_Nek6_Nek7	cd08224	0.00017	18	287
PTKc_Tec_Rlk	cd05114	5.8e-13	19	286
STKc_ROCK_NDR_like	cd05573	5.7e-06	19	325
STKc_PDK1	cd05581	2.1e-10	19	279
STKc_PKA	cd05580	0.00017	19	329
STKc_DMPK_like	cd05597	0.00088	19	342
STKc_MAST	cd05609	8.8e-08	19	338
STKc_PRKX_like	cd05612	0.00011	19	327
STKc_MST3_like	cd06609	4.4e-10	19	299
STKc_SLK_like	cd06611	4e-06	19	294
PKc_MEK	cd06615	6.7e-05	19	304
PKc_MAPKK	cd06605	3.4e-06	19	285
PKc_MAPKK_PBS2_like	cd06622	5.2e-06	19	347
PKc_MKK3_6	cd06617	2.1e-06	19	307
STKc_MST3	cd06641	0.00016	19	308
STKc_SLK	cd06643	4.3e-06	19	303
STKc_CdkB_plant	cd07837	0.00017	19	286
STKc_CDKL2_3	cd07846	0.00014	19	288
STKc_CDKL1_4	cd07847	3.2e-06	19	288
STKc_Nek6	cd08228	0.0006	19	287
STKc_Nek7	cd08229	8.9e-06	19	293
PTKc_EphR_B	cd05065	5.6e-07	20	289
STKc_MSK_N	cd05583	6.6e-05	20	307
STKc_MSK1_N	cd05613	0.00079	20	307
STKc_myosinIII_like	cd06608	5.7e-06	20	279
STKc_Pho85	cd07836	0.00098	20	309
STKc_MAPK	cd07834	0.00011	20	332
STKc_CDK1_euk	cd07861	0.0003	20	319
STKc_FA2-like	cd08529	1.5e-11	20	287
PTKc_Jak1_rpt2	cd05079	9.3e-06	21	289
STKc_MST1_2	cd06612	2.7e-10	21	279
STKc_CDK4_6_like	cd07838	6.9e-05	21	278
STKc_CDK9_like	cd07840	2.2e-06	21	278
STKc_CDK_like	cd07829	2.3e-08	21	279
PTKc_EphR_A10	cd05064	5.6e-06	22	292
PTK_Jak1_rpt1	cd05077	5.4e-05	22	286
PTKc_Btk_Bmx	cd05113	1.7e-15	22	286
STKc_MEKK2	cd06652	1.1e-06	22	288
STKc_MEKK3_like_1	cd06653	5e-09	22	287
STKc_OSR1_SPAK	cd06610	4.6e-11	23	278
PKc_MAPKK_plant_like	cd06623	1.7e-09	23	284
STKc_CDK1_like	cd07835	0.00021	23	315
STKc_Nek1	cd08218	8.6e-05	23	287
SPS1	COG0515	9.2e-30	23	437
STKc_GRK4_like	cd05605	7.1e-05	24	317
STKc_MAPKKK	cd06606	2.3e-16	24	279
STKc_MEKK3_like	cd06625	3.8e-13	24	287
STKc_MAPKKK_Byr2_lik	cd06628	1.1e-10	24	287
STKc_MEKK1	cd06630	3.2e-06	24	282
STKc_YSK4	cd06631	9.5e-08	24	288
STKc_MEKK1_plant	cd06632	4.8e-08	24	279
STKc_MEKK3	cd06651	2.3e-09	24	289
STKc_CCRK	cd07832	0.0001	24	279
STKc_CDK7	cd07841	1.7e-07	24	276
STKc_CNK2-like	cd08530	4.9e-06	24	292
PTKc_Csk_like	cd05039	8.9e-07	25	288
PTKc_Chk	cd05083	4.9e-07	25	286
STKc_RSK_N	cd05582	0.00026	25	344
STKc_p70S6K	cd05584	0.00014	25	365
STKc_PKN	cd05589	0.0007	25	337
STKc_MOK	cd07831	1.8e-05	25	278
STKc_Nek3	cd08219	3.7e-09	25	287
STKc_Nek10	cd08528	1e-05	25	287
PTKc	cd00192	1.1e-21	26	286
PTKc_Axl_like	cd05035	1.5e-07	26	289
PTK_Jak_rpt1	cd05037	7.3e-05	26	286
PTKc_Ack_like	cd05040	6.9e-13	26	290
PTKc_Fes_like	cd05041	2.3e-12	26	287
PTKc_c-ros	cd05044	2e-07	26	290
PTKc_RET	cd05045	2.6e-06	26	292
PTKc_Tie	cd05047	1.9e-05	26	290
PTKc_Met_Ron	cd05058	2.6e-07	26	291
PTKc_Tyro3	cd05074	2.2e-07	26	289
PTKc_Fes	cd05084	9.8e-10	26	287
PTKc_Fer	cd05085	2.5e-08	26	287
PTKc_Syk	cd05116	1.4e-08	26	290
STKc_PKC	cd05570	3e-05	26	329
STKc_PKB	cd05571	0.00015	26	372
STKc_Yank1	cd05578	3.1e-08	26	279
STKc_nPKC_epsilon	cd05591	0.00042	26	353
STKc_nPKC_theta_delt	cd05592	8e-05	26	366
STKc_nPKC_theta	cd05619	5e-05	26	365
STKc_MEKK4	cd06626	1.8e-09	26	279
STKc_Cdc7_like	cd06627	9.9e-11	26	279
STKc_TDY_MAPK_plant	cd07859	5.2e-05	26	361
STKc_Nek	cd08215	1.6e-15	26	288
STKc_Nek8	cd08220	1.4e-06	26	287
STKc_Nek9	cd08221	4e-06	26	288
STKc_Nek11	cd08222	5.3e-05	26	287
STKc_Nek4	cd08223	2e-06	26	287
STKc_Nek5	cd08225	0.00011	26	288
STKc_beta_ARK	cd05606	0.00014	27	299
PKc	cd00180	1.6e-61	28	285
PTKc_Aatyk	cd05042	0.00015	28	291
PTK_Jak2_Jak3_rpt1	cd05078	2.5e-06	28	286
PTKc_Zap-70	cd05115	1e-08	28	290
STKc_AGC	cd05123	1.3e-10	28	280
STKc_cGK_PKG	cd05572	2.3e-05	28	285
STKc_MAST_like	cd05579	1.3e-10	28	285
STKc_YPK1_like	cd05585	0.0002	28	350
STKc_Sck1_like	cd05586	0.00014	28	412
PTKc_Tec_like	cd05059	1.8e-12	30	293
PTKc_Syk_like	cd05060	2e-10	30	288
STKc_CMGC	cd05118	2.3e-07	30	278
STKc_MAK_like	cd07830	2.8e-05	30	279
STKc_Nek2	cd08217	2.6e-08	30	288
PKc_MAPKK_Pek1_like	cd06621	9e-05	31	288
PTKc_Tyk2_rpt2	cd05080	4.2e-06	37	293
PTKc_Jak2_Jak3_rpt2	cd05081	4e-08	37	289
STKc_MAPKKK_Bck1_lik	cd06629	0.00017	56	279
PKc_MAPKK_Byr1_like	cd06620	4.5e-05	59	305
STKc_MAPK15	cd07852	5.8e-05	66	302
Arp	COG0666	6.6e-29	298	534
ANK	cd00204	1.2e-38	356	481
ANK	cd00204	3.7e-40	488	613
Arp	COG0666	2.4e-20	536	753
ANK	cd00204	3.7e-34	620	745
Pkinase	pfam00069	4.4e-32	26	281
Ank	pfam00023	1.6e-05	394	426
Ank	pfam00023	6.8e-08	427	459
Ank	pfam00023	2.9e-08	460	492
Ank	pfam00023	2.2e-08	493	525
Ank	pfam00023	3.3e-06	526	558
Ank	pfam00023	2.4e-05	559	591
Ank	pfam00023	2.5e-06	592	624
Ank	pfam00023	2.1e-08	625	657
Ank	pfam00023	1.5e-06	658	690
Ank	pfam00023	9.5e-07	691	723
Pkinase_Tyr	pfam07714	8.7e-30	21	288
TyrKc	smart00219	2.5e-18	26	287
STYKc	smart00221	5.7e-33	26	287
S_TKc	smart00220	5.3e-36	32	289
ANK	smart00248	4.3e-05	427	456
ANK	smart00248	3e-07	460	489
ANK	smart00248	3.3e-07	493	522
ANK	smart00248	1.8e-05	526	555
ANK	smart00248	8.1e-07	592	621
ANK	smart00248	1.9e-06	625	654
ANK	smart00248	0.00012	691	720

Table of Mutations found on the Protein

Source ↕	Mut_ID ↕	Class ↕	HGVS ↕	Disease ↕
Swiss-Prot	VAR_036784	Polymorphism	p.ALA239THR	N/A
dbSNP	rs115800217	Polymorphism	p.ARG185GLN	N/A
Swiss-Prot	VAR_040360	Polymorphism	p.ARG122HIS	N/A
Swiss-Prot	VAR_040373	Polymorphism	p.ARG736LEU	N/A
Swiss-Prot	VAR_040370	Polymorphism	p.ASN653SER	N/A
Swiss-Prot	VAR_040359	Polymorphism	p.ASP4TYR	N/A
Swiss-Prot	VAR_040372	Polymorphism	p.GLN717LEU	N/A
Swiss-Prot	VAR_040365	Polymorphism	p.GLU376LYS	N/A
Swiss-Prot	VAR_040366	Polymorphism	p.GLU426LYS	N/A
Swiss-Prot	VAR_025010	Polymorphism	p.GLU713LYS	N/A
Swiss-Prot	VAR_040374	Polymorphism	p.GLU764LYS	N/A
Swiss-Prot	VAR_036785	Polymorphism	p.GLY318ARG	N/A
dbSNP	rs4938016	Polymorphism	p.GLY442ARG	N/A
Swiss-Prot	VAR_040367	Polymorphism	p.GLY451ARG	N/A
dbSNP	rs2734849	Polymorphism	p.HIS490ARG	N/A
Swiss-Prot	VAR_040364	Polymorphism	p.HIS367GLN	N/A
Swiss-Prot	VAR_040363	Polymorphism	p.LEU366PHE	N/A
Swiss-Prot	VAR_040362	Polymorphism	p.LYS347THR	N/A
Swiss-Prot	VAR_040361	Polymorphism	p.PRO276LEU	N/A
Swiss-Prot	VAR_040369	Polymorphism	p.PRO596LEU	N/A
dbSNP	rs56006094	Polymorphism	p.SER670GLY	N/A
Swiss-Prot	VAR_040368	Polymorphism	p.THR595ILE	N/A
OMIM	608774.0001	Disease	p.GLU713LYS	DOPAMINE RECEPTOR D2, REDUCED BRAIN DENSITY OF

Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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