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Results for the Protein: P04629
94730402

NTRK1_HUMAN RecName: Full=High affinity nerve growth factor receptor; AltName: Full=Neurotrophic tyrosine kinase receptor type 1; AltName: Full=TRK1-transforming tyrosine kinase protein; AltName: Full=Tropomyosin-related kinase A; AltName: Full=Tyrosine kinase receptor; AltName: Full=Tyrosine kinase receptor A; Short=Trk-A; AltName: Full=gp140trk; AltName: Full=p140-TrkA; Flags: Precursor

Known Diseases associated with this Protein:
  CONGENITAL INSENSITIVITY TO PAIN WITH ANHIDROSIS (CIPA)
  INSENSITIVITY TO PAIN, CONGENITAL, WITH ANHIDROSIS
  THYROID CARCINOMA, FAMILIAL MEDULLARY
19
16
7
2
26
Tips:
 The Domains on the Default View are decided by the Domain's E-Value.

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Default View:

LRRCT - smart00082
I-set - pfam07679
Ig_TrkABC_d4 - cd04972
Ig_TrkB_d5 - cd05855
Ig_TrKABC_d5 - cd04971
PTKc_PDGFR_alpha - cd05105
PTKc_PDGFR_beta - cd05107
PTKc_Kit - cd05104
PTKc_CSF-1R - cd05106
PTKc_PDGFR - cd05055
STKc_PAK_I - cd06647
STKc_PAK - cd06614
STKc_TAO - cd06607
STKc_PAK_II - cd06648
PTKc_FGFR1 - cd05098
STKc_PAK6 - cd06659
PTKc_FGFR2 - cd05101
PTKc_FGFR3 - cd05100
PTKc_FGFR4 - cd05099
STKc_BUR1 - cd07866
STKc_myosinIIIA - cd06638
STKc_CDK12 - cd07864
STKc_TAO2 - cd06634
PKc_MKK7 - cd06618
PTK_Tyk2_rpt1 - cd05076
STKc_ASK - cd06624
PTKc_EGFR - cd05108
STKc_STK10_LOK - cd06644
PTKc_HER2 - cd05109
STKc_SLK - cd06643
PTKc_VEGFR3 - cd05102
PTK_HER3 - cd05111
PTKc_VEGFR2 - cd05103
PTKc_Tie2 - cd05088
PTKc_HER4 - cd05110
PTKc_VEGFR - cd05054
PTKc_Hck - cd05073
PTKc_Src - cd05071
PTKc_Csk - cd05082
STKc_CDK9 - cd07865
PTKc_Fyn_Yrk - cd05070
STKc_MAPK15 - cd07852
STKc_Yank1 - cd05578
PTKc_Chk - cd05083
PTKc_Lyn - cd05072
PTKc_Csk_like - cd05039
PTKc_ALK_LTK - cd05036
PTKc_Src_like - cd05034
PTKc_Yes - cd05069
PTKc_Abl - cd05052
PTKc_InsR_like - cd05032
PTKc_FAK - cd05056
PTKc_Lck_Blk - cd05067
PTKc_Frk_like - cd05068
PTKc_InsR - cd05061
PTKc_IGF-1R - cd05062
PKc_MAPKK_Byr1_like - cd06620
PTKc_Ror2 - cd05091
PTKc_DDR_like - cd05097
STKc_MAP4K3 - cd06645
PTKc_DDR1 - cd05096
STKc_PCTAIRE3 - cd07871
PTKc_DDR2 - cd05095
STKc_PFTAIRE2 - cd07870
STKc_PCTAIRE_like - cd07844
STKc_MAP4K5 - cd06646
PTKc_Ror - cd05048
PTKc_Musk - cd05050
PTK_CCK4 - cd05046
PTKc_Trk - cd05049
PTKc_TrkC - cd05094
PTKc_EGFR_like - cd05057
PTKc_DDR - cd05051
PTKc_EphR_A2 - cd05063
PTKc_TrkB - cd05093
PTKc_Ror1 - cd05090
PTKc_TrkA - cd05092
PTKc_EphR_A10 - cd05064
PTKc_Jak2_Jak3_rpt2 - cd05081
PTKc_Itk - cd05112
PTKc_Tyk2_rpt2 - cd05080
PKc_MKK4 - cd06616
PTKc_Btk_Bmx - cd05113
PTKc_Tec_Rlk - cd05114
PTK_Ryk - cd05043
PTKc_Jak1_rpt2 - cd05079
PTKc_EphR - cd05033
PTKc_Jak_rpt2 - cd05038
PTKc_FGFR - cd05053
PTKc_EphR_A - cd05066
PTKc_EphR_B - cd05065
PTKc_Tec_like - cd05059
STKc_CDKL1_4 - cd07847
STKc_CDK10 - cd07845
STKc_MST4 - cd06640
STKc_MAP4K3_like - cd06613
STKc_MST3 - cd06641
STKc_STK25-YSK1 - cd06642
STKc_Nek6_Nek7 - cd08224
STKc_MEKK2 - cd06652
STKc_CDK4 - cd07863
PTKc_Srm_Brk - cd05148
STKc_CDK6 - cd07862
STKc_Nek3 - cd08219
STKc_Nek1 - cd08218
STKc_Nek5 - cd08225
STKc_Nek7 - cd08229
STKc_CDK7 - cd07841
SPS1 - COG0515
STKc_CNK2-like - cd08530
STKc_Nek6 - cd08228
PTKc_Tie1 - cd05089
PKc_MAPKK - cd06605
PKc_MAPKK_plant_like - cd06623
STKc_PDK1 - cd05581
STKc_PKA - cd05580
STKc_myosinIII_like - cd06608
STKc_PRKX_like - cd05612
PKc_MAPKK_Pek1_like - cd06621
STKc_OSR1_SPAK - cd06610
PKc_MKK3_6 - cd06617
PKc_MAPKK_PBS2_like - cd06622
PKc_MEK - cd06615
STKc_Nek - cd08215
STKc_CDK1_euk - cd07861
STKc_Nek11 - cd08222
STKc_Nek10 - cd08528
STKc_FA2-like - cd08529
STKc_CdkB_plant - cd07837
STKc_Nek4 - cd08223
STKc_Nek2 - cd08217
STKc_MST3_like - cd06609
STKc_GRK4_like - cd05605
STKc_MSK_N - cd05583
PKc_STE - cd05122
STKc_Pho85 - cd07836
STKc_MST1_2 - cd06612
STKc_MAPK - cd07834
STKc_Cdc7_like - cd06627
PTKc_RET - cd05045
STKc_MOK - cd07831
TyrKc - smart00219
Pkinase_Tyr - pfam07714
PTKc_Axl_like - cd05035
STYKc - smart00221
PTKc_Tyro3 - cd05074
PTKc_Axl - cd05075
STKc_CDK2_3 - cd07860
Pkinase - pfam00069
STKc_MAK_like - cd07830
STKc_CDK1_like - cd07835
STKc_RSK_N - cd05582
STKc_MEKK3_like_1 - cd06653
STKc_MEKK3_like - cd06625
STKc_MAPKKK_Bck1_lik - cd06629
STKc_MEKK3 - cd06651
STKc_Nek8 - cd08220
STKc_CDKL2_3 - cd07846
STKc_NAK1_like - cd06917
STKc_YSK4 - cd06631
STKc_MEKK1 - cd06630
STKc_MEKK1_plant - cd06632
STKc_MEKK4 - cd06626
STKc_CDK5 - cd07839
STKc_MAPKKK_Byr2_lik - cd06628
STKc_MAPKKK - cd06606
PTKc_Ack_like - cd05040
PTK_Jak_rpt1 - cd05037
PTKc - cd00192
PTKc_Syk - cd05116
PTKc_Fes_like - cd05041
PTKc_Aatyk - cd05042
PTKc_Syk_like - cd05060
STKc_CDK9_like - cd07840
STKc_CDK4_6_like - cd07838
STKc_CDK8_like - cd07842
STKc_CDC2L1 - cd07843
PTKc_Aatyk2 - cd05086
PTKc_Aatyk1_Aatyk3 - cd05087
PTKc_Zap-70 - cd05115
STKc_CDKL - cd07833
PTK_Jak2_Jak3_rpt1 - cd05078
PTKc_Fes - cd05084
STKc_CDK_like - cd07829
STKc_CMGC - cd05118
STKc_SLK_like - cd06611
PTK_Jak1_rpt1 - cd05077
STKc_CCRK - cd07832
STKc_Nek9 - cd08221
STKc_nPKC_theta - cd05619
STKc_GRK - cd05577
PTKc_Tie - cd05047
PTKc_c-ros - cd05044
PKc - cd00180
STKc_MAST_like - cd05579
PTKc_Met_Ron - cd05058
STKc_PKC - cd05570
PTKc_Fer - cd05085
STKc_cGK_PKG - cd05572
STKc_AGC - cd05123
S_TKc - smart00220
KIND - smart00750


Swiss-Prot Protein: P04629
Identical to: NP_002520
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Domains found on the Protein

Domain ↕CD Accession ↕E-Value ↕Start ↕End ↕
Ig_TrkABC_d4cd049722.6e-36195282
Ig_TrKABC_d5cd049719.3e-52299379
Ig_TrkB_d5cd058553.1e-34299379
PTKc_PDGFR_alphacd051053.1e-17464787
PTKc_PDGFR_betacd051075e-22479786
PTKc_Kitcd051044.2e-30485784
PTKc_CSF-1Rcd051061.8e-37485786
PTKc_PDGFRcd050551.3e-28486785
STKc_PAK_Icd066470.00096487796
STKc_PAKcd066141.7e-11491795
STKc_TAOcd066070.00047493792
PTKc_FGFR1cd050986.6e-56494789
STKc_PAK_IIcd066482.4e-06494795
PTKc_FGFR2cd051017.4e-53495789
STKc_PAK6cd066595.4e-05495795
PTKc_FGFR4cd050992.6e-58497794
PTKc_FGFR3cd051002.7e-40497794
STKc_myosinIIIAcd066380.00029497781
STKc_CDK12cd078642.3e-08497792
STKc_BUR1cd078663.3e-07497771
PKc_MKK7cd066182.6e-05499787
STKc_TAO2cd066340.00047499793
PTK_Tyk2_rpt1cd050763.4e-06500782
STKc_ASKcd066242.5e-07501783
PTKc_VEGFRcd050543.3e-34502788
PTKc_Tie2cd050881.1e-42502794
PTKc_VEGFR3cd051025.6e-36502788
PTKc_VEGFR2cd051031.9e-33502788
PTKc_HER4cd051101e-25502796
PTK_HER3cd051112e-39502795
PTKc_HER2cd051099.2e-41502795
PTKc_EGFRcd051081.7e-22502796
STKc_SLKcd066435e-06502787
STKc_STK10_LOKcd066442.5e-05502789
PTKc_InsR_likecd050324.2e-98503783
PTKc_Src_likecd050342.9e-67503784
PTKc_ALK_LTKcd050362.4e-91503783
PTKc_Csk_likecd050393.4e-39503784
PTKc_Ablcd050521.2e-72503785
PTKc_FAKcd050568.9e-77503789
PTKc_InsRcd050618.6e-77503796
PTKc_IGF-1Rcd050621e-76503783
PTKc_Lck_Blkcd050676.5e-49503784
PTKc_Frk_likecd050681e-72503784
PTKc_Yescd050692.5e-42503784
PTKc_Fyn_Yrkcd050707.4e-49503784
PTKc_Srccd050718.6e-44503786
PTKc_Lyncd050722.5e-54503784
PTKc_Hckcd050731.3e-50503784
PTKc_Cskcd050821.7e-51503784
PTKc_Chkcd050831.4e-56503784
STKc_Yank1cd055785e-06503787
STKc_MAPK15cd078526.7e-05503795
STKc_CDK9cd078656.3e-05503792
PTK_CCK4cd050467.8e-72504783
PTKc_Rorcd050482.6e-116504784
PTKc_Trkcd050492.3e-219504783
PTKc_Muskcd050501.6e-127504783
PTKc_DDRcd050514.4e-101504783
PTKc_EGFR_likecd050571.6e-54504795
PTKc_EphR_A2cd050633e-63504785
PTKc_EphR_A10cd050643.7e-55504785
PTKc_Ror1cd050904.7e-92504784
PTKc_TrkAcd050922.6e-241504783
PTKc_TrkBcd050931e-205504793
PTKc_TrkCcd050947.8e-191504793
PTKc_DDR2cd050952e-87504783
PTKc_DDR1cd050963.7e-80504783
PTKc_DDR_likecd050972.3e-83504783
PTKc_Ror2cd050913e-78504784
PKc_MAPKK_Byr1_likecd066202.7e-08504787
STKc_MAP4K3cd066450.00048504782
STKc_MAP4K5cd066460.00027504782
STKc_PCTAIRE_likecd078440.00016504792
STKc_PCTAIRE3cd078710.00024504792
STKc_PFTAIRE2cd078700.00025504792
PTKc_EphRcd050332.6e-68505785
PTK_Rykcd050431.6e-25505781
PTKc_Jak_rpt2cd050384e-67505785
PTKc_FGFRcd050532.1e-66505782
PTKc_Tec_likecd050592.8e-68505782
PTKc_EphR_Bcd050653.3e-58505785
PTKc_EphR_Acd050664.2e-64505785
PTKc_Jak1_rpt2cd050792.6e-42505785
PTKc_Tyk2_rpt2cd050807.7e-40505786
PTKc_Jak2_Jak3_rpt2cd050816.4e-50505785
PTKc_Itkcd051121.5e-64505782
PTKc_Btk_Bmxcd051132e-69505782
PTKc_Tec_Rlkcd051141.5e-64505782
PKc_MKK4cd066160.00026505795
STKc_MAP4K3_likecd066137.2e-09506778
STKc_MST4cd066400.00038506795
STKc_MST3cd066410.00017506795
STKc_STK25-YSK1cd066426.5e-05506796
STKc_CDK10cd078451e-06506758
STKc_CDKL1_4cd078470.00011506783
PTKc_Srm_Brkcd051481.2e-64507784
STKc_MEKK2cd066525e-06507784
STKc_CDK4cd078638.5e-05507792
STKc_Nek6_Nek7cd082241.5e-07507786
PTKc_Tie1cd050892.8e-48508793
STKc_PKAcd055809e-05508794
STKc_PDK1cd055816.4e-11508792
STKc_PRKX_likecd056129.6e-05508796
PKc_MAPKKcd066052.9e-06508793
STKc_myosinIII_likecd066081.2e-05508781
STKc_OSR1_SPAKcd066104.5e-08508775
PKc_MEKcd066155.7e-06508795
PKc_MKK3_6cd066170.00024508783
PKc_MAPKK_Pek1_likecd066211.9e-05508764
PKc_MAPKK_PBS2_likecd066227.7e-05508795
PKc_MAPKK_plant_likecd066231.2e-13508779
STKc_CDK7cd078411.5e-08508785
STKc_CDK6cd078620.00074508795
STKc_Nek1cd082183e-06508783
STKc_Nek3cd082191.4e-10508783
STKc_Nek5cd082251.2e-06508783
STKc_Nek6cd082281.9e-06508786
STKc_Nek7cd082294.6e-07508783
STKc_CNK2-likecd085302.8e-08508781
SPS1COG05151.9e-05508796
PTKc_RETcd050453.7e-58509788
PKc_STEcd051223.2e-13509780
STKc_MSK_Ncd055830.00062509793
STKc_GRK4_likecd056050.00037509794
STKc_MST3_likecd066099.1e-08509792
STKc_MST1_2cd066122.6e-09509774
STKc_Cdc7_likecd066271.5e-13509774
STKc_MOKcd078318.6e-05509781
STKc_MAPKcd078346.5e-06509793
STKc_Pho85cd078365.9e-05509781
STKc_CdkB_plantcd078371.9e-07509782
STKc_CDK1_eukcd078610.00061509792
STKc_Nekcd082151e-13509783
STKc_Nek2cd082174.7e-08509781
STKc_Nek11cd082223.1e-07509783
STKc_Nek4cd082233.3e-07509783
STKc_Nek10cd085280.00017509783
STKc_FA2-likecd085292.4e-09509774
PTKc_Axl_likecd050351.1e-58510785
PTKc_Tyro3cd050742.5e-56510785
PTKc_Axlcd050751.7e-51510785
STKc_CDK2_3cd078600.00064510792
STKc_CDK1_likecd078357.1e-06511792
STKc_MAK_likecd078304.3e-10511783
STKc_RSK_Ncd055820.00014512794
STKc_MEKK3_likecd066251.1e-11512783
STKc_MAPKKK_Bck1_likcd066292.8e-11512779
STKc_MEKK3cd066513.5e-09512785
STKc_MEKK3_like_1cd066533.9e-07512784
STKc_MAPKKKcd066066.8e-19513781
STKc_MAPKKK_Byr2_likcd066283.6e-12513783
STKc_MEKK1cd066301.6e-07513782
STKc_YSK4cd066312.8e-09513781
STKc_MEKK1_plantcd066321.4e-10513777
STKc_MEKK4cd066263.3e-09513779
STKc_NAK1_likecd069172.9e-07513782
STKc_CDK5cd078392.5e-05513781
STKc_CDKL2_3cd078463.4e-05513781
STKc_Nek8cd082201.9e-06513785
PTKccd001928.6e-131514782
PTK_Jak_rpt1cd050373.1e-12514782
PTKc_Ack_likecd050407.6e-63514783
PTKc_Fes_likecd050412.7e-55514783
PTKc_Aatykcd050421.4e-35514783
PTKc_Syk_likecd050601.9e-57514786
PTKc_Sykcd051167.2e-49514786
PTK_Jak1_rpt1cd050775e-08515782
PTK_Jak2_Jak3_rpt1cd050781.4e-12515778
PTKc_Fescd050841.8e-64515783
PTKc_Aatyk2cd050861.4e-39515783
PTKc_Aatyk1_Aatyk3cd050876.9e-45515783
PTKc_Zap-70cd051152e-52515786
STKc_CMGCcd051181.1e-07515781
STKc_SLK_likecd066119.2e-08515787
STKc_CDK_likecd078292e-10515781
STKc_CDKLcd078339.2e-06515781
STKc_CDK4_6_likecd078385.3e-06515792
STKc_CDK9_likecd078402.5e-10515795
STKc_CDK8_likecd078425.5e-05515779
STKc_CDC2L1cd078430.00014515792
PKccd001808.1e-60516781
PTKc_c-roscd050443.8e-83516783
PTKc_Tiecd050472.3e-54516786
PTKc_Met_Roncd050588.1e-61516787
PTKc_Fercd050857.5e-54516783
STKc_AGCcd051236.2e-08516779
STKc_cGK_PKGcd055722.4e-07516779
STKc_PKCcd055704.3e-05516792
STKc_GRKcd055770.00065516793
STKc_MAST_likecd055792.8e-09516779
STKc_nPKC_thetacd056190.001516794
STKc_CCRKcd078328.8e-09516782
STKc_Nek9cd082212.2e-08516783
Pkinasepfam000695.8e-43510781
LRRCTsmart000821.2e-09148192
I-setpfam076790.00026194282
Pkinase_Tyrpfam077142.1e-138510781
TyrKcsmart002192e-135510781
STYKcsmart002211.1e-50510792
S_TKcsmart002202.8e-44520790
KINDsmart007500.00014615791

Table of Mutations found on the Protein

Source ↕Mut_ID ↕Class ↕HGVS ↕Disease ↕
Swiss-ProtVAR_041462Polymorphismp.ALA107VALN/A
Swiss-ProtVAR_041467Polymorphismp.ARG452CYSN/A
Swiss-ProtVAR_009631Diseasep.ARG654CYSCongenital insensitivity to pain with anhidrosis (CIPA)
Swiss-ProtVAR_041466Polymorphismp.ARG444GLNN/A
Swiss-ProtVAR_009636Polymorphismp.ARG780GLNN/A
Swiss-ProtVAR_041465Polymorphismp.ARG260GLYN/A
Swiss-ProtVAR_009635Diseasep.ARG780PROCongenital insensitivity to pain with anhidrosis (CIPA)
Swiss-ProtVAR_009623Polymorphismp.ARG85SERN/A
Swiss-ProtVAR_068480Polymorphismp.ARG6TRPN/A
Swiss-ProtVAR_009630Diseasep.ARG649TRPCongenital insensitivity to pain with anhidrosis (CIPA)
Swiss-ProtVAR_009632Polymorphismp.ASP674TYRN/A
Swiss-ProtVAR_041461Polymorphismp.GLN80ARGN/A
Swiss-ProtVAR_068482Diseasep.GLU492LYSCongenital insensitivity to pain with anhidrosis (CIPA)
Swiss-ProtVAR_009626Diseasep.GLY522ARGCongenital insensitivity to pain with anhidrosis (CIPA)
Swiss-ProtVAR_004103Diseasep.GLY577ARGCongenital insensitivity to pain with anhidrosis (CIPA)
Swiss-ProtVAR_049714Polymorphismp.GLY18GLUN/A
Swiss-ProtVAR_009634Diseasep.GLY714SERCongenital insensitivity to pain with anhidrosis (CIPA)
dbSNPrs6339 Polymorphismp.GLY613VALN/A
dbSNPrs6336 Polymorphismp.HIS604TYRN/A
Swiss-ProtVAR_009625Diseasep.LEU213PROCongenital insensitivity to pain with anhidrosis (CIPA)
Swiss-ProtVAR_009624Diseasep.LEU93PROCongenital insensitivity to pain with anhidrosis (CIPA)
Swiss-ProtVAR_041468Polymorphismp.MET566THRN/A
Swiss-ProtVAR_009627Diseasep.MET587VALCongenital insensitivity to pain with anhidrosis (CIPA)
Swiss-ProtVAR_009633Diseasep.PRO695LEUCongenital insensitivity to pain with anhidrosis (CIPA)
Swiss-ProtVAR_041463Polymorphismp.THR237METN/A
Swiss-ProtVAR_068481Diseasep.TYR359CYSCongenital insensitivity to pain with anhidrosis (CIPA)
Swiss-ProtVAR_041464Polymorphismp.VAL238GLYN/A
Swiss-ProtVAR_041469Polymorphismp.VAL790ILEN/A
OMIM191315.0004 Diseasep.ARG774PROINSENSITIVITY TO PAIN, CONGENITAL, WITH ANHIDROSIS
OMIM191315.0003 Diseasep.GLY571ARGINSENSITIVITY TO PAIN, CONGENITAL, WITH ANHIDROSIS
OMIM191315.0013 Diseasep.MET581VALINSENSITIVITY TO PAIN, CONGENITAL, WITH ANHIDROSIS
OMIM191315.0011 Diseasep.PRO689LEUINSENSITIVITY TO PAIN, CONGENITAL, WITH ANHIDROSIS
OMIM191315.0012 Diseasep.TYR359CYSINSENSITIVITY TO PAIN, CONGENITAL, WITH ANHIDROSIS
OMIM191315.0008 Diseasep.TYR604HISTHYROID CARCINOMA, FAMILIAL MEDULLARY
OMIM191315.0009 Diseasep.VAL613GLYTHYROID CARCINOMA, FAMILIAL MEDULLARY



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