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  Domain Name: ACD_sHsps-like
Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally active as large oligomers consisting of multiple subunits, and are believed to be ATP-independent chaperones that prevent aggregation and are important in refolding in combination with other Hsps.
No pairwise interactions are available for this conserved domain.

Total Mutations Found: 13
Total Disease Mutations Found: 13
This domain occurred 8 times on human genes (11 proteins).



  CATARACT 16, CONGENITAL LAMELLAR
  CATARACT 9, MULTIPLE TYPES, WITH OR WITHOUT MICROCORNEA
  CATARACT 9, NUCLEAR, WITH MICROCORNEA
  CATARACT 9, TOTAL
  CHARCOT-MARIE-TOOTH DISEASE, AXONAL, TYPE 2F
  CHARCOT-MARIE-TOOTH DISEASE, AXONAL, TYPE 2F, INCLUDED
  MYOPATHY, MYOFIBRILLAR, 2
  NEURONOPATHY, DISTAL HEREDITARY MOTOR, TYPE IIA
  NEURONOPATHY, DISTAL HEREDITARY MOTOR, TYPE IIB
  NEURONOPATHY, DISTAL HEREDITARY MOTOR, TYPE IIB, AUTOSOMAL RECESSIVE


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


Feature Name:Total Found:
putative dimer interface












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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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