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  Domain Name: Aida-C2
C2 domain of Aida. This is the C2 domain in the axin interaction dorsal-associated (Aida) proteins. In all proteins the Aida-C2 domain is found in the C-terminal portion of the protein. these proteins also contain diverse domains related to cytoskeletal functions, e.g. EF hands, coiled coils, IQ calmodulin-binding motifs, ankyrin repeats and myosin head motor domain. Aida blocks Axin-mediated JNK (c-Jun N-terminal kinases) activation by disrupting Axin homodimerisation, thereby having an anti-dorsalisation action in zebrafish. Axin is a scaffold protein that controls multiple, important pathways, including the canonical Wnt pathway and the JNK signalling pathway and besides its ventralising activity mediated though facilitating beta-catenin degradation, possesses a dorsalising activity that is mediated by Axin-induced JNK activation.
No pairwise interactions found for the domain Aida-C2

Total Mutations Found: 0
Total Disease Mutations Found: 0
This domain occurred 1 times on human genes (1 proteins).




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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


No Conserved Features/Sites Found for Aida-C2













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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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