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  Domain Name: Anoctamin
Calcium-activated chloride channel. The family carries eight putative transmembrane domains, and, although it has no similarity to other known channel proteins, it is clearly a calcium-activated ionic channel. It is expressed in various secretory epithelia, the retina and sensory neurons, and mediates receptor-activated chloride currents in diverse physiological processes.
No pairwise interactions found for the domain Anoctamin

Total Mutations Found: 31
Total Disease Mutations Found: 14
This domain occurred 10 times on human genes (18 proteins).



  DYSTONIA 24
  GNATHODIAPHYSEAL DYSPLASIA
  MIYOSHI MUSCULAR DYSTROPHY 3
  MUSCULAR DYSTROPHY, LIMB-GIRDLE, TYPE 2L, INCLUDED
  SPINOCEREBELLAR ATAXIA, AUTOSOMAL RECESSIVE 10


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


No Conserved Features/Sites Found for Anoctamin















































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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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