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  Domain Name: Arl10_like
Arf-like 9 (Arl9) and 10 (Arl10) GTPases. Arl10-like subfamily. Arl9/Arl10 was identified from a human cancer-derived EST dataset. No functional information about the subfamily is available at the current time, but crystal structures of human Arl10b and Arl10c have been solved.
No pairwise interactions are available for this conserved domain.

Total Mutations Found: 28
Total Disease Mutations Found: 16
This domain occurred 81 times on human genes (127 proteins).



  CONE-ROD DYSTROPHY 18
  GRISCELLI SYNDROME, TYPE 2
  NOONAN SYNDROME 8
  OVARIAN CANCER, SOMATIC
  WARBURG MICRO SYNDROME 3


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 The histograms below the weblogo indicate mutations found on the domain. Red is for disease (OMIM) and blue is for SNPs.

 Functional Features are displayed as orange boxes under the histograms. You can choose which features are displayed in the box below.



Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


Feature Name:Total Found:
GTP/Mg2+ binding site
putative effector interac
putative GEF interaction
putative GAP interaction
Switch I region
Switch II region
interswitch region
G1 box
G2 box
G3 box
G4 box
G5 box
















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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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