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  Domain Name: BRCA-2_OB1
BRCA2, oligonucleotide/oligosaccharide-binding, domain 1. Members of this family assume an OB fold, which consists of a highly curved five-stranded beta-sheet that closes on itself to form a beta-barrel. OB1 has a shallow groove formed by one face of the curved sheet and is demarcated by two loops, one between beta 1 and beta 2 and another between beta 4 and beta 5, which allows for weak single strand DNA binding. The domain also binds the 70-amino acid DSS1 (deleted in split-hand/split foot syndrome) protein, which was originally identified as one of three genes that map to a 1.5-Mb locus deleted in an inherited developmental malformation syndrome.
No pairwise interactions found for the domain BRCA-2_OB1

Total Mutations Found: 2
Total Disease Mutations Found: 2
This domain occurred 1 times on human genes (2 proteins).



  FANCONI ANEMIA, COMPLEMENTATION GROUP D1
  RECLASSIFIED - VARIANT OF UNKNOWN SIGNIFICANCE


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


No Conserved Features/Sites Found for BRCA-2_OB1









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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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