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  Domain Name: Band_3_cyto
Band 3 cytoplasmic domain. This family contains the cytoplasmic domain of the Band 3 anion exchange proteins that exchange Cl-/HCO3-. Band 3 constitutes the most abundant polypeptide in the red blood cell membrane, comprising 25% of the total membrane protein. The cytoplasmic domain of band 3 functions primarily as an anchoring site for other membrane-associated proteins. Included among the protein ligands of cdb3 are ankyrin, protein 4.2, protein 4.1, glyceraldehyde-3-phosphate dehydrogenase (GAPDH), phosphofructokinase, aldolase, hemoglobin, hemichromes, and the protein tyrosine kinase (p72syk).
No pairwise interactions found for the domain Band_3_cyto

Total Mutations Found: 14
Total Disease Mutations Found: 6
This domain occurred 9 times on human genes (29 proteins).



  RENAL TUBULAR ACIDOSIS, PROXIMAL, WITH OCULAR ABNORMALITIES AND MENTAL
  RETARDATION
  SPHEROCYTOSIS, TYPE 4, DUE TO BAND 3 CAPE TOWN
  SPHEROCYTOSIS, TYPE 4, DUE TO BAND 3 FUKUOKA
  SPHEROCYTOSIS, TYPE 4, DUE TO BAND 3 LYON
  SPHEROCYTOSIS, TYPE 4, DUE TO BAND 3 TUSCALOOSA


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


No Conserved Features/Sites Found for Band_3_cyto
















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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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