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  Domain Name: CA_like
Cadherin repeat-like domain. Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.
No pairwise interactions are available for this conserved domain.

Total Mutations Found: 289
Total Disease Mutations Found: 50
This domain occurred 71 times on human genes (123 proteins).



  ARRHYTHMOGENIC RIGHT VENTRICULAR DYSPLASIA, FAMILIAL, 10
  BREAST CANCER, LOBULAR, SOMATIC
  DEAFNESS, AUTOSOMAL RECESSIVE 12
  DEAFNESS, AUTOSOMAL RECESSIVE 23
  EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 9
  GASTRIC CANCER, HEREDITARY DIFFUSE
  HIRSCHSPRUNG DISEASE, SUSCEPTIBILITY TO, 1
  HYPOTRICHOSIS 6
  HYPOTRICHOSIS, CONGENITAL, WITH JUVENILE MACULAR DYSTROPHY
  MENTAL RETARDATION, AUTOSOMAL DOMINANT 3
  PALMOPLANTAR KERATODERMA I, STRIATE
  RECLASSIFIED - VARIANT OF UNKNOWN SIGNIFICANCE
  RENAL AGENESIS
  USHER SYNDROME, TYPE ID
  USHER SYNDROME, TYPE IF
  VAN MALDERGEM SYNDROME 2


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


Feature Name:Total Found:
Ca2+ binding site