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  Domain Name: CLECT_CEL-1_like
C-type lectin-like domain (CTLD) of the type found in CEL-1 from Cucumaria echinata and Echinoidin from Anthocidaris crassispina. CLECT_CEL-1_like: C-type lectin-like domain (CTLD) of the type found in CEL-1 from Cucumaria echinata and Echinoidin from Anthocidaris crassispina. CTLD refers to a domain homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins. The CEL-1 CTLD binds three calcium ions and has a high specificity for N-acteylgalactosamine (GalNAc). CEL-1 exhibits strong cytotoxicity which is inhibited by GalNAc. This protein may play a role as a toxin defending against predation. Echinoidin is found in the coelomic fluid of the sea urchin and is specific for GalBeta1-3GalNAc. Echinoidin has a cell adhesive activity towards human cancer cells which is not mediated through the CTLD. Both CEL-1 and Echinoidin are multimeric proteins comprised of multiple dimers linked by disulfide bonds.
No pairwise interactions are available for this conserved domain.

Total Mutations Found: 90
Total Disease Mutations Found: 16
This domain occurred 65 times on human genes (144 proteins).



  3MC SYNDROME 2
  BIRBECK GRANULE DEFICIENCY
  PULMONARY FIBROSIS, IDIOPATHIC
  PULMONARY FIBROSIS, IDIOPATHIC, SUSCEPTIBILITY TO
  SUSCEPTIBILITY TO LEPROSY AND MULTIBACILLARY LEPROSY


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


Feature Name:Total Found:
carbohydrate binding
calcium binding site 3
calcium binding site 1
dimer interface












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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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