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  Domain Name: DEXDc
DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
No pairwise interactions are available for this conserved domain.

Total Mutations Found: 47
Total Disease Mutations Found: 18
This domain occurred 93 times on human genes (152 proteins).



  ALPHA-THALASSEMIA/MENTAL RETARDATION SYNDROME, X-LINKED
  BREAST CANCER, INVASIVE DUCTAL
  CHARGE SYNDROME
  COLON CANCER, SOMATIC
  DISTAL SPINAL MUSCULAR ATROPHY, AUTOSOMAL RECESSIVE, 1
  EPILEPTIC ENCEPHALOPATHY, CHILDHOOD-ONSET
  MENTAL RETARDATION, AUTOSOMAL DOMINANT 16
  NICOLAIDES-BARAITSER SYNDROME
  PLEUROPULMONARY BLASTOMA (PPB)
  SCHIMKE IMMUNOOSSEOUS DYSPLASIA
  TRICHOHEPATOENTERIC SYNDROME 2


Tips:
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 The histograms below the weblogo indicate mutations found on the domain. Red is for disease (OMIM) and blue is for SNPs.

 Functional Features are displayed as orange boxes under the histograms. You can choose which features are displayed in the box below.



Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


Feature Name:Total Found:
ATP binding site
putative Mg++ binding sit




















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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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