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  Domain Name: Drf_GBD
Diaphanous GTPase-binding Domain. This domain is bound to by GTP-attached Rho proteins, leading to activation of the Drf protein.

Total Mutations Found: 32
Total Disease Mutations Found: 18
This domain occurred 9 times on human genes (20 proteins).



  CHARCOT-MARIE-TOOTH DISEASE, DOMINANT INTERMEDIATE E
  CHARCOT-MARIE-TOOTH DISEASE, DOMINANT, INTERMEDIATE TYPE, E (CMTDIE)
  FOCAL SEGMENTAL GLOMERULOSCLEROSIS 5
  FOCAL SEGMENTAL GLOMERULOSCLEROSIS 5 (FSGS5)


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 The histograms below the weblogo indicate mutations found on the domain. Red is for disease (OMIM) and blue is for SNPs.

 Functional Features are displayed as orange boxes under the histograms. You can choose which features are displayed in the box below.



Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


No Conserved Features/Sites Found for Drf_GBD












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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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