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  Domain Name: Esterase_lipase
Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These catalytic residues are responsible for the nucleophilic attack on the carbonyl carbon atom of the ester bond. In contrast with other alpha/beta hydrolase fold family members, p-nitrobenzyl esterase and acetylcholine esterase have a Glu instead of Asp at the active site carboxylate.
No pairwise interactions are available for this conserved domain.

Total Mutations Found: 28
Total Disease Mutations Found: 7
This domain occurred 13 times on human genes (27 proteins).



  ASPERGER SYNDROME, SUSCEPTIBILITY TO, X-LINKED 1, INCLUDED
  AUTISM, SUSCEPTIBILITY TO, X-LINKED 1
  CARBOXYLESTERASE 1 DEFICIENCY
  THYROID DYSHORMONOGENESIS 3


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


Feature Name:Total Found:
catalytic triad
substrate binding pocket
























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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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