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  Domain Name: FGF
Acidic and basic fibroblast growth factor family. Mitogens that stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The family play essential roles in patterning and differentiation during vertebrate embryogenesis, and have neurotrophic activities.

Total Mutations Found: 28
Total Disease Mutations Found: 27
This domain occurred 24 times on human genes (62 proteins).



  APLASIA OF LACRIMAL AND SALIVARY GLANDS
  DEAFNESS, CONGENITAL, WITH INNER EAR AGENESIS, MICROTIA, AND MICRODONTIA
  HYPOGONADOTROPIC HYPOGONADISM 20 WITH ANOSMIA, SUSCEPTIBILITY TO
  HYPOGONADOTROPIC HYPOGONADISM 6 WITH OR WITHOUT ANOSMIA
  HYPOGONADOTROPIC HYPOGONADISM 6 WITHOUT ANOSMIA
  LADD SYNDROME
  LADD SYNDROME, INCLUDED
  MULTIPLE SYNOSTOSES SYNDROME 3
  SPINOCEREBELLAR ATAXIA 27
  TUMORAL CALCINOSIS, FAMILIAL, HYPERPHOSPHATEMIC


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


No Conserved Features/Sites Found for FGF









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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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