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  Domain Name: FH
Forkhead (FH), also known as a "winged helix". FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. This family of transcription factor domains, which bind to B-DNA as monomers, are also found in the Hepatocyte nuclear factor (HNF) proteins, which provide tissue-specific gene regulation. The structure contains 2 flexible loops or "wings" in the C-terminal region, hence the term winged helix.
No pairwise interactions are available for this conserved domain.

Total Mutations Found: 38
Total Disease Mutations Found: 35
This domain occurred 49 times on human genes (82 proteins).



  ALVEOLAR CAPILLARY DYSPLASIA WITH MISALIGNMENT OF PULMONARY VEINS
  AXENFELD ANOMALY
  AXENFELD ANOMALY, INCLUDED;;
  AXENFELD-RIEGER ANOMALY
  AXENFELD-RIEGER SYNDROME, TYPE 3
  AXENFELD-RIEGER SYNDROME, TYPE 3, INCLUDED;;
  BLEPHAROPHIMOSIS, PTOSIS, AND EPICANTHUS INVERSUS, TYPE I
  DEVELOPMENTAL VERBAL DYSPRAXIA
  HYPOTHYROIDISM, ATHYROIDAL, WITH SPIKY HAIR AND CLEFT PALATE
  HYPOTHYROIDISM, THYROIDAL, WITH SPIKY HAIR AND CLEFT PALATE
  IMMUNODYSREGULATION, POLYENDOCRINOPATHY, AND ENTEROPATHY, X-LINKED
  LYMPHEDEMA-DISTICHIASIS SYNDROME
  MENTAL RETARDATION WITH LANGUAGE IMPAIRMENT AND AUTISTIC FEATURES
  PETERS ANOMALY, INCLUDED
  RETT SYNDROME, CONGENITAL VARIANT
  RIEGER ANOMALY


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


Feature Name:Total Found:
DNA binding site










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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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