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  Domain Name: FHA
Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins localize to the nucleus, where they participate in establishing or maintaining cell cycle checkpoints, DNA repair, or transcriptional regulation. Members of the FHA family include: Dun1, Rad53, Cds1, Mek1, KAPP(kinase-associated protein phosphatase),and Ki-67 (a human nuclear protein related to cell proliferation).
No pairwise interactions are available for this conserved domain.

Total Mutations Found: 48
Total Disease Mutations Found: 13
This domain occurred 29 times on human genes (52 proteins).



  CANCER OF MULTIPLE TYPES, SUSCEPTIBILITY TO, I
  COLORECTAL CANCER, SUSCEPTIBILITY TO, INCLUDED;;
  LI-FRAUMENI SYNDROME 2
  PROSTATE CANCER, SOMATIC


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


Feature Name:Total Found:
phosphopeptide binding si













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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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