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  Domain Name: FN3
Fibronectin type 3 domain. One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.

Total Mutations Found: 265
Total Disease Mutations Found: 65
This domain occurred 148 times on human genes (353 proteins).



  AMEGAKARYOCYTIC THROMBOCYTOPENIA, CONGENITAL
  AMYLOIDOSIS, PRIMARY LOCALIZED CUTANEOUS, 1
  AMYLOIDOSIS, PRIMARY LOCALIZED CUTANEOUS, 2
  ATYPICAL MYCOBACTERIAL INFECTION, FAMILIAL DISSEMINATED
  B CELL-POSITIVE, NK CELL-POSITIVE
  CARDIOMYOPATHY, DILATED, 1MM
  CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 4
  CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 4, INCLUDED
  COLD-INDUCED SWEATING SYNDROME 1
  COMBINED IMMUNODEFICIENCY, X-LINKED
  CRANIOSYNOSTOSIS AND DENTAL ANOMALIES
  EHLERS-DANLOS SYNDROME, HYPERMOBILITY TYPE
  EPIDERMOLYSIS BULLOSA DYSTROPHICA, AUTOSOMAL RECESSIVE
  EPIDERMOLYSIS BULLOSA, JUNCTIONAL, WITH PYLORIC ATRESIA
  GAZE PALSY, FAMILIAL HORIZONTAL, WITH PROGRESSIVE SCOLIOSIS
  GLOMERULOPATHY WITH FIBRONECTIN DEPOSITS 2
  HOLOPROSENCEPHALY 11
  HYPERPROLACTINEMIA (1 FAMILY)
  HYPOGONADOTROPIC HYPOGONADISM 1 WITH ANOSMIA
  LARON SYNDROME
  LARON SYNDROME WITH UNDETECTABLE SERUM GH-BINDING PROTEIN
  LEFT VENTRICULAR NONCOMPACTION 10
  MULTIPLE FIBROADENOMAS OF THE BREAST
  RETINITIS PIGMENTOSA 39
  SEVERE COMBINED IMMUNODEFICIENCY, AUTOSOMAL RECESSIVE, T CELL-NEGATIVE,
  SHORT STATURE, IDIOPATHIC, AUTOSOMAL


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Range on the Protein:  

   Protein ID            Protein Position