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  Domain Name: Fumble
Fumble. Fumble is required for cell division in Drosophila. Mutants lacking fumble exhibit abnormalities in bipolar spindle organisation, chromosome segregation, and contractile ring formation. Analyses have demonstrated that encodes three protein isoforms, all of which contain a domain with high similarity to the pantothenate kinases of A. nidulans and mouse. A role of fumble in membrane synthesis has been proposed.
No pairwise interactions found for the domain Fumble

Total Mutations Found: 17
Total Disease Mutations Found: 11
This domain occurred 4 times on human genes (7 proteins).



  HARP SYNDROME
  NEURODEGENERATION WITH BRAIN IRON ACCUMULATION 1
  NEURODEGENERATION WITH BRAIN IRON ACCUMULATION 1, ATYPICAL
  NEURODEGENERATION WITH BRAIN IRON ACCUMULATION 1, ATYPICAL, INCLUDED


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


No Conserved Features/Sites Found for Fumble















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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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