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  Domain Name: GCD
Glutaryl-CoA dehydrogenase. Glutaryl-CoA dehydrogenase (GCD). GCD is an acyl-CoA dehydrogenase, which catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and carbon dioxide in the catabolism of lysine, hydroxylysine, and tryptophan. It uses electron transfer flavoprotein (ETF) as an electron acceptor. GCD is a homotetramer. GCD deficiency leads to a severe neurological disorder in humans.
No pairwise interactions are available for this conserved domain.

Total Mutations Found: 76
Total Disease Mutations Found: 57
This domain occurred 11 times on human genes (26 proteins).



  2-@METHYLBUTYRYL-COA DEHYDROGENASE DEFICIENCY
  ISOVALERIC ACIDEMIA
  ISOVALERIC ACIDEMIA, TYPE I
  PEROXISOMAL ACYL-COA OXIDASE DEFICIENCY
  SCAD DEFICIENCY
  SCAD DEFICIENCY, MILD
  VLCAD DEFICIENCY


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


Feature Name:Total Found:
FAD binding site
substrate binding pocket
catalytic base


















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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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