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  Domain Name: GS
GS motif. Aa approx. 30 amino acid motif that precedes the kinase domain in types I and II TGF beta receptors. Mutation of two or more of the serines or threonines in the TTSGSGSG of TGF-beta type I receptor impairs phosphorylation and signaling activity.
No pairwise interactions found for the domain GS

Total Mutations Found: 3
Total Disease Mutations Found: 3
This domain occurred 7 times on human genes (13 proteins).



  FIBRODYSPLASIA OSSIFICANS PROGRESSIVA
  LOEYS-DIETZ SYNDROME, TYPE 1A


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


No Conserved Features/Sites Found for GS





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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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