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  Domain Name: HDc
Metal dependent phosphohydrolases with conserved 'HD' motif. Includes eukaryotic cyclic nucleotide phosphodiesterases (PDEc). This profile/HMM does not detect HD homologues in bacterial glycine aminoacyl-tRNA synthetases (beta subunit).
No pairwise interactions found for the domain HDc

Total Mutations Found: 34
Total Disease Mutations Found: 28
This domain occurred 22 times on human genes (76 proteins).



  ACHROMATOPISIA 5
  ACRODYSOSTOSIS 2
  AICARDI-GOUTIERES SYNDROME 5
  CHILBLAIN LUPUS 2, INCLUDED
  RETINITIS PIGMENTOSA 40
  RETINITIS PIGMENTOSA 43


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


No Conserved Features/Sites Found for HDc















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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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