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  Domain Name: HELICc
Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may not be an autonomously folding unit, but an integral part of the helicase; 4 helicase superfamilies at present according to the organization of their signature motifs; all helicases share the ability to unwind nucleic acid duplexes with a distinct directional polarity; they utilize the free energy from nucleoside triphosphate hydrolysis to fuel their translocation along DNA, unwinding the duplex in the process
No pairwise interactions are available for this conserved domain.

Total Mutations Found: 47
Total Disease Mutations Found: 14
This domain occurred 91 times on human genes (152 proteins).



  AUTISM, SUSCEPTIBILITY TO, 18
  MENTAL RETARDATION, AUTOSOMAL DOMINANT 16
  MENTAL RETARDATION-HYPOTONIC FACIES SYNDROME, X-LINKED
  NICOLAIDES-BARAITSER SYNDROME
  PLEUROPULMONARY BLASTOMA
  RHABDOID TUMOR PREDISPOSITION SYNDROME 2
  SCHIMKE IMMUNOOSSEOUS DYSPLASIA


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 Functional Features are displayed as orange boxes under the histograms. You can choose which features are displayed in the box below.



Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


Feature Name:Total Found:
nucleotide binding region
ATP-binding site














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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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