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  Domain Name: HMG-box
High Mobility Group (HMG)-box is found in a variety of eukaryotic chromosomal proteins and transcription factors. HMGs bind to the minor groove of DNA and have been classified by DNA binding preferences. Two phylogenically distinct groups of Class I proteins bind DNA in a sequence specific fashion and contain a single HMG box. One group (SOX-TCF) includes transcription factors, TCF-1, -3, -4; and also SRY and LEF-1, which bind four-way DNA junctions and duplex DNA targets. The second group (MATA) includes fungal mating type gene products MC, MATA1 and Ste11. Class II and III proteins (HMGB-UBF) bind DNA in a non-sequence specific fashion and contain two or more tandem HMG boxes. Class II members include non-histone chromosomal proteins, HMG1 and HMG2, which bind to bent or distorted DNA such as four-way DNA junctions, synthetic DNA cruciforms, kinked cisplatin-modified DNA, DNA bulges, cross-overs in supercoiled DNA, and can cause looping of linear DNA. Class III members include nucleolar and mitochondrial transcription factors, UBF and mtTF1, which bind four-way DNA junctions.
No pairwise interactions are available for this conserved domain.

Total Mutations Found: 19
Total Disease Mutations Found: 15
This domain occurred 45 times on human genes (95 proteins).



  ACAMPOMELIC CAMPOMELIC DYSPLASIA
  CAMPOMELIC DYSPLASIA
  CAMPOMELIC DYSPLASIA WITH AUTOSOMAL SEX REVERSAL
  HYPOTRICHOSIS-LYMPHEDEMA-TELANGIECTASIA SYNDROME
  MENINGIOMA, FAMILIAL, SUSCEPTIBILITY TO
  MICROPHTHALMIA, SYNDROMIC 3
  VARIANT OF UNKNOWN SIGNIFICANCE


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   Protein ID            Protein Position

Domain Position:  


Feature Name:Total Found:
DNA binding site










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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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