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  Domain Name: HNF-1_N
Hepatocyte nuclear factor 1 (HNF-1), N terminus. This family consists of the N terminus of homeobox-containing transcription factor HNF-1. This region contains a dimerisation sequence and an acidic region that may be involved in transcription activation. Mutations and the common Ala/Val 98 polymorphism in HNF-1 cause the type 3 form of maturity-onset diabetes of the young (MODY3).
No pairwise interactions found for the domain HNF-1_N

Total Mutations Found: 73
Total Disease Mutations Found: 51
This domain occurred 2 times on human genes (5 proteins).



  DIABETES MELLITUS, INSULIN-DEPENDENT, 20 (IDDM20)
  DIABETES MELLITUS, NON-INSULIN-DEPENDENT (NIDDM)
  MATURITY-ONSET DIABETES OF THE YOUNG 3 (MODY3)
  MATURITY-ONSET DIABETES OF THE YOUNG, TYPE 3
  RENAL CELL CARCINOMA, CHROMO
  RENAL CELL CARCINOMA, CLEAR CELL, INCLUDED;;
  RENAL CYSTS AND DIABETES SYNDROME
  RENAL CYSTS AND DIABETES SYNDROME (RCAD)


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


No Conserved Features/Sites Found for HNF-1_N











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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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