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  Domain Name: Hap2_elong
Histone acetylation protein 2. Hap2 is one of three histone acetyltransferases proteins that, in yeasts, are found associated with elongating forms of RNA polymerase II (Elongator). The Haps can be isolated in two forms, as a six-subunit complex with Elongator and as a complex of the three proteins on their own. The role of the Hap complex in transcription is still speculative, being possibly to keep the HAT activity of free Elongator in check, allowing histone acetylation only in the presence of a transcribing polymerase, or the interaction with Haps might render Elongator susceptible to modifications thereby altering its activity.
No pairwise interactions found for the domain Hap2_elong

Total Mutations Found: 2
Total Disease Mutations Found: 0
This domain occurred 1 times on human genes (5 proteins).




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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


No Conserved Features/Sites Found for Hap2_elong















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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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