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  Domain Name: Hydrolase
haloacid dehalogenase-like hydrolase. This family is structurally different from the alpha/beta hydrolase family (pfam00561). This family includes L-2-haloacid dehalogenase, epoxide hydrolases and phosphatases. The structure of the family consists of two domains. One is an inserted four helix bundle, which is the least well conserved region of the alignment, between residues 16 and 96 of Pseudomonas sp. (S)-2-haloacid dehalogenase 1. The rest of the fold is composed of the core alpha/beta domain. Those members with the characteristic DxD triad at the N-terminus are probably phosphatidylglycerolphosphate (PGP) phosphatases involved in cardiolipin biosynthesis in the mitochondria.

Total Mutations Found: 99
Total Disease Mutations Found: 45
This domain occurred 20 times on human genes (57 proteins).



  ANTERIOR SEGMENT ANOMALIES
  ANTERIOR SEGMENT ANOMALIES AND CATARACT
  BRANCHIOOTIC SYNDROME 1
  BRANCHIOOTORENAL SYNDROME 1
  BRANCHIOOTORENAL SYNDROME 1, INCLUDED
  BRANCHIOOTORENAL SYNDROME WITH CATARACT
  BRODY MYOPATHY
  HAILEY-HAILEY DISEASE
  OCCIPITAL HORN SYNDROME
  PHOSPHOSERINE PHOSPHATASE DEFICIENCY
  WILSON DISEASE


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


No Conserved Features/Sites Found for Hydrolase

















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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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