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  Domain Name: IL4Ra_N
Interleukin-4 receptor alpha chain, N-terminal. Members of this family are related in overall topology to fibronectin type III modules and fold into a sandwich comprising seven antiparallel beta sheets arranged in a three-strand and a four-strand beta-pleated sheet. They are required for binding of interleukin-4 to the receptor alpha chain, which is a crucial event for the generation of a Th2-dominated early immune response.
No pairwise interactions found for the domain IL4Ra_N

Total Mutations Found: 4
Total Disease Mutations Found: 2
This domain occurred 1 times on human genes (4 proteins).



  ACQUIRED IMMUNODEFICIENCY SYNDROME, SLOW PROGRESSION TO, INCLUDED
  ASTHMA, ATOPIC


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


No Conserved Features/Sites Found for IL4Ra_N







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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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