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  Domain Name: Ig_MOG_like
Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG). Ig_MOG_like: immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG). MOG, a minor component of the myelin sheath, is an important CNS-specific autoantigen, linked to the pathogenesis of multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). It is a transmembrane protein having an extracellular Ig domain. MOG is expressed in the CNS on the outermost lamellae of the myelin sheath, and on the surface of oligodendrocytes, and may participate in the completion, compaction, and/or maintenance of myelin. This group also includes butyrophilin (BTN). BTN is the most abundant protein in bovine milk-fat globule membrane (MFGM).
No pairwise interactions are available for this conserved domain.

Total Mutations Found: 20
Total Disease Mutations Found: 5
This domain occurred 29 times on human genes (80 proteins).



  CONGENITAL SHORT BOWEL SYNDROME
  NARCOLEPSY 7
  RADIN BLOOD GROUP ANTIGEN
  SCIANNA BLOOD GROUP SYSTEM, SC:-1,2
  SCIANNA BLOOD GROUP SYSTEM, STAR ANTIGEN


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


Feature Name:Total Found:
antigen binding site










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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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