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  Domain Name: KISc
Kinesin motor domain. This catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Kinesins are microtubule-dependent molecular motors that play important roles in intracellular transport and in cell division. In most kinesins, the motor domain is found at the N-terminus (N-type), in some its is found in the middle (M-type), or C-terminal (C-type). N-type and M-type kinesins are (+) end-directed motors, while C-type kinesins are (-) end-directed motors, i.e. they transport cargo towards the (-) end of the microtubule. Kinesin motor domains hydrolyze ATP at a rate of about 80 per second, and move along the microtubule at a speed of about 6400 Angstroms per second. To achieve that, kinesin head groups work in pairs. Upon replacing ADP with ATP, a kinesin motor domain increases its affinity for microtubule binding and locks in place. Also, the neck linker binds to the motor domain, which repositions the other head domain through the coiled-coil domain close to a second tubulin dimer, about 80 Angstroms along the microtubule. Meanwhile, ATP hydrolysis takes place, and when the second head domain binds to the microtubule, the first domain again replaces ADP with ATP, triggering a conformational change that pulls the first domain forward.
No pairwise interactions are available for this conserved domain.

Total Mutations Found: 96
Total Disease Mutations Found: 27
This domain occurred 44 times on human genes (80 proteins).



  ACROCALLOSAL SYNDROME
  BARDET-BIEDL SYNDROME (BBS)
  CHARCOT-MARIE-TOOTH DISEASE, AXONAL, TYPE 2A1
  CONGENITAL FIBROSIS OF EXTRAOCULAR MUSCLES 1 (CFEOM1)
  CORTICAL DYSPLASIA, COMPLEX, WITH OTHER BRAIN MALFORMATIONS 2 (1 FAMILY)
  CORTICAL DYSPLASIA, COMPLEX, WITH OTHER BRAIN MALFORMATIONS 3
  FIBROSIS OF EXTRAOCULAR MUSCLES, CONGENITAL, 1
  MENTAL RETARDATION, AUTOSOMAL DOMINANT 9
  MICROCEPHALY WITH OR WITHOUT CHORIORETINOPATHY, LYMPHEDEMA, OR MENTAL
  RETARDATION
  SPASTIC PARAPLEGIA 10
  SPASTIC PARAPLEGIA 10 WITH OR WITHOUT PERIPHERAL NEUROPATHY
  SPASTIC PARAPLEGIA 10 WITH PERIPHERAL NEUROPATHY
  SPASTIC PARAPLEGIA 30, AUTOSOMAL RECESSIVE
  SPONDYLOEPIMETAPHYSEAL DYSPLASIA WITH JOINT LAXITY, TYPE 2


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


Feature Name:Total Found:
ATP binding site
microtubule interaction s


































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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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