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  Domain Name: Kelch_1
Kelch motif. The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that the Drosophila ring canal kelch protein is related to Galactose Oxidase, for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.
No pairwise interactions found for the domain Kelch_1

Total Mutations Found: 33
Total Disease Mutations Found: 25
This domain occurred 58 times on human genes (75 proteins).



  METHYLMALONIC ACIDEMIA AND HOMOCYSTEINEMIA, CBLX TYPE
  NEMALINE MYOPATHY 8
  PSEUDOHYPOALDOSTERONISM, TYPE IID, AUTOSOMAL DOMINANT
  PSEUDOHYPOALDOSTERONISM, TYPE IID, AUTOSOMAL DOMINANT OR RECESSIVE
  PSEUDOHYPOALDOSTERONISM, TYPE IID, AUTOSOMAL RECESSIVE


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


No Conserved Features/Sites Found for Kelch_1






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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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