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  Domain Name: Kelch_2
Kelch motif. The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Drosophila ring canal kelch protein is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.
No pairwise interactions found for the domain Kelch_2

Total Mutations Found: 12
Total Disease Mutations Found: 7
This domain occurred 48 times on human genes (74 proteins).



  MENTAL RETARDATION, X-LINKED 3
  PSEUDOHYPOALDOSTERONISM, TYPE IID, AUTOSOMAL DOMINANT
  PSEUDOHYPOALDOSTERONISM, TYPE IID, AUTOSOMAL RECESSIVE


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


No Conserved Features/Sites Found for Kelch_2






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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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