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  Domain Name: LamG
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.
No pairwise interactions are available for this conserved domain.

Total Mutations Found: 99
Total Disease Mutations Found: 36
This domain occurred 40 times on human genes (88 proteins).



  AUTISM, SUSCEPTIBILITY TO, 15
  EHLERS-DANLOS SYNDROME 1 (EDS1)
  EHLERS-DANLOS SYNDROME 2 (EDS2)
  LEBER CONGENITAL AMAUROSIS 8
  MUSCULAR DYSTROPHY, CONGENITAL MEROSIN-DEFICIENT
  MUSCULAR DYSTROPHY, CONGENITAL, DUE TO PARTIAL LAMA2 DEFICIENCY
  MYASTHENIA, LIMB-GIRDLE, FAMILIAL
  OTOSPONDYLOMEGAEPIPHYSEAL DYSPLASIA
  PITT-HOPKINS-LIKE SYNDROME 2
  RETINITIS PIGMENTOSA 12
  RETINITIS PIGMENTOSA 25
  STICKLER SYNDROME, TYPE II
  THROMBOPHILIA DUE TO PROTEIN S DEFICIENCY, AUTOSOMAL DOMINANT
  THROMBOPHILIA DUE TO PROTEIN S DEFICIENCY, AUTOSOMAL RECESSIVE


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


No Conserved Features/Sites Found for LamG












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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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