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  Domain Name: MIP
Major intrinsic protein. MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.
No pairwise interactions found for the domain MIP

Total Mutations Found: 56
Total Disease Mutations Found: 37
This domain occurred 12 times on human genes (21 proteins).



  AQUAPORIN 1 DEFICIENCY
  CATARACT 15, LAMELLAR WITH SUTURAL OPACITIES
  CATARACT 15, MULTIPLE TYPES
  CATARACT 15, MULTIPLE TYPES (CTRCT15)
  COLTON-NULL, INCLUDED
  DIABETES INSIPIDUS, NEPHROGENIC, AUTOSOMAL (ANDI)
  DIABETES INSIPIDUS, NEPHROGENIC, AUTOSOMAL RECESSIVE
  KERATODERMA, PALMOPLANTAR, BOTHNIAN TYPE (PPKB)
  PALMOPLANTAR KERATODERMA, BOTHNIAN TYPE


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


No Conserved Features/Sites Found for MIP










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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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