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  Domain Name: MutL_C
MutL C terminal dimerisation domain. MutL and MutS are key components of the DNA repair machinery that corrects replication errors. MutS recognises mispaired or unpaired bases in a DNA duplex and in the presence of ATP, recruits MutL to form a DNA signaling complex for repair. The N terminal region of MutL contains the ATPase domain and the C terminal is involved in dimerisation.
No pairwise interactions found for the domain MutL_C

Total Mutations Found: 3
Total Disease Mutations Found: 2
This domain occurred 2 times on human genes (4 proteins).



  COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 7
  MISMATCH REPAIR CANCER SYNDROME


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


No Conserved Features/Sites Found for MutL_C




















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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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