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  Domain Name: Myosin_tail_1
Myosin tail. The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.
No pairwise interactions found for the domain Myosin_tail_1

Total Mutations Found: 48
Total Disease Mutations Found: 16
This domain occurred 16 times on human genes (30 proteins).



  AORTIC ANEURYSM, FAMILIAL THORACIC 4
  CARDIOMYOPATHY, DILATED, 1EE
  CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 1
  CARDIOMYOPATHY, FAMILIAL HYPERTROPHIC, 1, INCLUDED;;
  FECHTNER SYNDROME
  FECHTNER SYNDROME, INCLUDED
  FECHTNER SYNDROME, INCLUDED;;
  LAING DISTAL MYOPATHY
  LEFT VENTRICULAR NONCOMPACTION 5
  LEFT VENTRICULAR NONCOMPACTION 5, INCLUD
  MACROTHROMBOCYTOPENIA AND PROGRESSIVE SENSORINEURAL DEAFNESS, INCLUD
  MAY-HEGGLIN ANOMALY
  MYOPATHY, MYOSIN STORAGE
  MYOPATHY, MYOSIN STORAGE, INCLUDED
  SCAPULOPERONEAL MYOPATHY, MYH7-RELATED, INCLUDED
  SEBASTIAN SYNDROME


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Range on the Protein:  

   Protein ID            Protein Position

Domain Position:  


No Conserved Features/Sites Found for Myosin_tail_1



























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Please Cite: Peterson, T.A., Adadey, A., Santana-Cruz ,I., Sun, Y., Winder A, Kann, M.G., (2010) DMDM: Domain Mapping of Disease Mutations. Bioinformatics 26 (19), 2458-2459.

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